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Genetic testing


Katya773

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Katya773 Apprentice

Hi all! I have fatigue bloating and gas with stomach pain and sometimes diarrhea for a couple of years until I figured it might be gluten related. No matter how much I sleep I am exhausted. I have “chicken “ skin for years and feel foggy minded. I recently tested positive for the two or more Celiac genes hla dqa1 05 and DQ2.2. Also higher risk for autoimmune disorders. My mom also has gluten intolerance. Been as gluten free as possible with some relief but fatigue and sinus headaches all the time and some bloating remains. I know with celiac testing you need t eat gluten before you get tested.  I’m just worried that that might trigger for me to get more sick. Does anyone else feel this way in regards to testing?


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cyclinglady Grand Master
22 hours ago, Katya773 said:

Hi all! I have fatigue bloating and gas with stomach pain and sometimes diarrhea for a couple of years until I figured it might be gluten related. No matter how much I sleep I am exhausted. I have “chicken “ skin for years and feel foggy minded. I recently tested positive for the two or more Celiac genes hla dqa1 05 and DQ2.2. Also higher risk for autoimmune disorders. My mom also has gluten intolerance. Been as gluten free as possible with some relief but fatigue and sinus headaches all the time and some bloating remains. I know with celiac testing you need t eat gluten before you get tested.  I’m just worried that that might trigger for me to get more sick. Does anyone else feel this way in regards to testing?

Welcome! 

Genetic testing is used to help rule out celiac disease normally.  Why?  Because some 35% or more of the population carries the genes that could develop into celiac disease.  Only a very few actually do develop it.   Perhaps you should consider getting tested.  I know my diagnosis has helped others in my family.  I also know that my hubby went Gluten Free some 17 years ago per the poor advice of my allergist and his doctor.  He will be the first to say that I have had WAY more support from family friends and medical for the past five years.  

Yes, a gluten challenge can be difficult (and you should be under a doctor’s care), but it might be worth pursuing, especially since you just started the diet.  My hubby deeply regrets not getting tested. 

  • 2 weeks later...
Katya773 Apprentice

Thanks! Yes i will consider blood testing because with two positive genetic tests and  family history, I would feel better knowing! 

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    • trents
      Yes, all your test scores point to celiac disease. I think this is the first time I have ever seen all positives on a full celiac panel. But then, seldom do do physicians order a full celiac panel. Many or most will only order the TTG-IGA. By the way, your score for that one at 128 far exceeds 10x the upper limit of normal. In Europe, many doctors would grant you an official diagnosis of celiac disease on that alone. And diagnosing on high TTG-IGA scores alone is very slowly gaining traction in the USA. But don't make the mistake of starting a gluten free diet until all testing for celiac is done. It is likely that your doctor may refer you for an endoscopy/biopsy to confirm the results of the antibody testing and you don't want to begin the gluten free diet until that is over or you may invalidate the outcome.
    • Jessica H
      Hi Trent, yes I started a new thread with the same title but added (Updated) on the end of the title. 
    • trents
      Do you mean you started a whole new thread? In other words, somewhere else in the forum? I still don't see any reference ranges in any of your posts in this thread. I'm looking for something like this: Gliadin Deaminated Antibody IgA - 21.0 (<17) Gliadin Deaminated Antibody IgG - 19.0 (<15) Tissue Transglutaminase IgA Ab - 128.0 (<12) Tissue Transglutaminase IgG - 27.0 (<14) Immunoglobulin A (IgA) - 167.0 (100-400)   The < value is the limit of normal. The last one, Immunoglobulin A (IgA) is not a celiac antibody test per se but what we call "total IGA" which is looking for IGA deficiency. If a person is IGA deficient, their IGA celiac antibody test scores will be artificially low which can result in false negatives. Total IGA "normal" is given as a range rather than a less than.    
    • Jessica H
      I started a new post, I'm sorry I forgot to add that! 
    • trents
      I don't see the reference ranges. There is a very short time window for editing posts so if you tried to put them in your original post, it probably didn't work. Start a new post instead with the scores and reference ranges together.
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