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twointow

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twointow Newbie

Questions in bold...

How long do i need to be eating gluten b4 testing? I have been having a lot of potentially unrelated issues that seem to be neurlogic in nature so I am seeing a neurologist. He says my symptoms are most consistent with MS but that has been ruled out already so he is unsure of the source. He is doing a laundry list of tests to try to find the source of my symptoms. Among them is a Gliaden antibody serum test, I was gluten-free for a few months (suspecting gluten sensitivity), went off for about a month due to financial constraints, returned to it for about a week then was told to eat normally for Gliaden antibody serum test (when I asked about it after a quick net search and it mentioned being related to celiac testing). Can the gliadin antibody serum test diagnose or indicate potential celiac or am I barking up the wrong tree? Does going gluten-free for a week affect the timetable at all on how long I need to keep gluten in my diet? I really don't want to do a normal diet any longer than I absolutely have to because whether its gluten or not SOMETHING that is removed when I am gluten-free is making a difference. TMI but for one my tummy is a hot mess and my poo is urgent, frequent, quite upleasant and cloudy. This is just one example but its a major one because it just about keeps me homebound. So any info is greatly appreciated.


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cyclinglady Grand Master
1 hour ago, twointow said:

Questions in bold...

How long do i need to be eating gluten b4 testing? I have been having a lot of potentially unrelated issues that seem to be neurlogic in nature so I am seeing a neurologist. He says my symptoms are most consistent with MS but that has been ruled out already so he is unsure of the source. He is doing a laundry list of tests to try to find the source of my symptoms. Among them is a Gliaden antibody serum test, I was gluten-free for a few months (suspecting gluten sensitivity), went off for about a month due to financial constraints, returned to it for about a week then was told to eat normally for Gliaden antibody serum test (when I asked about it after a quick net search and it mentioned being related to celiac testing). Can the gliadin antibody serum test diagnose or indicate potential celiac or am I barking up the wrong tree? Does going gluten-free for a week affect the timetable at all on how long I need to keep gluten in my diet? I really don't want to do a normal diet any longer than I absolutely have to because whether its gluten or not SOMETHING that is removed when I am gluten-free is making a difference. TMI but for one my tummy is a hot mess and my poo is urgent, frequent, quite upleasant and cloudy. This is just one example but its a major one because it just about keeps me homebound. So any info is greatly appreciated.

A gluten challenge before a celiac antibodies testing requires about weeks of a gluten-containing diet.  It is only 2 to 4 if a person proceeds to an endoscopy to obtain intestinal biopsies.

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I  would ask for a full celiac antibodies blood panel and not just the one you mentioned.  There is a reason there are several celiac antibodies tests — not everyone  tests positive to all of them and some people test negative to all of them.    In that case, an endoscopy should be ordered if celiac disease is strongly suspected.  

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GFinDC Veteran

Yep, about 12 weeks eating gluten for the blood antibody testing.

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    • trents
      @KRipple, thank you for the lab results from your husband's celiac disease blood antibody testing. The lab result you share would seem to be the tTG-IGA (Tissue Transglutaminase IGA) and the test result is in excess of 10x normal. This is significant as there is an increasing tendency for physicians to grant a celiac disease diagnosis on the basis of antibody testing alone when the scores on that particular test exceed 10x normal. This trend started in the UK during the COVID pandemic when there was tremendous pressure on the medical system over there and it has spread to the USA. The tTG-IGA is the centerpiece of celiac disease blood antibody testing. All this to say that some doctors would grant a celiac disease diagnosis on your husband's bloodwork alone and not feel a need to go forward with an endoscopy with biopsy. This is something you and your husband might wish to take up with his physicians. In view of his many health issues it might be wise to avoid any further damage to his small bowel lining by the continuing consumption of gluten and also to allow healing of such to progress. The lining of the small bowel is the place where essentially all of our nutrition is absorbed. This is why celiac disease when it is not addressed with a gluten free diet for many years typically results in additional health problems that are tied to nutritional deficiencies. The millions and millions of tiny finger-like projections that make up the nutrient absorbing surface of the small bowel lining are worn down by the constant inflammation from gluten consumption. In celiac disease, the immune system has been tricked into labeling gluten as an invader. As these finger-like projections are worn down, the efficiency of nutrient absorption becomes more and more compromised. We call this villous atrophy.   
    • KRipple
      Thank you so much! And sorry for not responding sooner. I've been scouring the hospital records and can find nothing other than the following results (no lab info provided): Component Transglutaminase IgA   Normal Range: 0 - 15.0 U/mL >250.0 U/mL High   We live in Olympia, WA and I will be calling University of Washington Hospital - Roosevelt in Seattle first thing tomorrow. They seem to be the most knowledgeable about complex endocrine issues like APS 2 (and perhaps the dynamics of how APS 2 and Celiacs can affect each other). His diarrhea has not abated even without eating gluten, but that could be a presentation of either Celiac's or Addison's. So complicated. We don't have a date for endoscopy yet. I will let my husband know about resuming gluten.    Again, thank you so much for sharing your knowledge with me!
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