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Was this test for IGa correctly done?


Gluten free

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Gluten free Newbie

Hi. I am in a new part of the country- Florida. I had my first lower and upper scope. History of stomach ca of aunt, father had diverticulitis/2' of bowel removed.  I do not know if he was ever tested for celiac/gluten (1970's). Me: Abdominal pain, severe constipation for me, joint pain, nausea, amongst other complaints. Asthma and total non functioning thyroid. I was test for gluten allergy about 2010 which came up positive . Five points above the high end if I remember correctly. A close friend (ER doc) tried to convince me to go gluten-free for a few years as going gluten-free helped him tremendously and I promised I would give it a try. As he was at my place often I did so to not to risk contaminating his food. (rest in peace, Chuck). I was gluten-free for about 5 years when gastro doc here in FL did my scopes. They did IGa bloodwork which was negative. Shouldn't I have been on gluten diet or is that no longer needed today?  ( gluten-free diet has helped about 50-75%. When I 'fell off the wagon' a couple times the first year I would feel fine first couple days then get very ill. I am extremely careful with diet. Thx 


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cyclinglady Grand Master

All celiac testing requires you to be on a full gluten diet.  It is 8 to 12 weeks prior to the blood test and 2 to 4 weeks prior to an endoscopy.  Sounds like your GI is clueless which is alarming.  Why isn’t he following the Amercan Gastroenterologist Association’s guidelines for celiac disease testing?  Even worse what else is he missing (e.g. cancer)?   I would strongly recommend a new GI who is celiac savvy.

Congratulations!   Your celiac disease is in remission.  It is the best news!  Everyone with celiac disease hopes for an “all healed” diagnosis!  Good job on the gluten-free diet.  

kareng Grand Master
3 hours ago, Gluten free said:

Hi. I am in a new part of the country- Florida. I had my first lower and upper scope. History of stomach ca of aunt, father had diverticulitis/2' of bowel removed.  I do not know if he was ever tested for celiac/gluten (1970's). Me: Abdominal pain, severe constipation for me, joint pain, nausea, amongst other complaints. Asthma and total non functioning thyroid. I was test for gluten allergy about 2010 which came up positive . Five points above the high end if I remember correctly. A close friend (ER doc) tried to convince me to go gluten-free for a few years as going gluten-free helped him tremendously and I promised I would give it a try. As he was at my place often I did so to not to risk contaminating his food. (rest in peace, Chuck). I was gluten-free for about 5 years when gastro doc here in FL did my scopes. They did IGa bloodwork which was negative. Shouldn't I have been on gluten diet or is that no longer needed today?  ( gluten-free diet has helped about 50-75%. When I 'fell off the wagon' a couple times the first year I would feel fine first couple days then get very ill. I am extremely careful with diet. Thx 

Wait.... you were positive for Celiac but didn’t think going gluten-free would be a good idea?  But then someone talked you into it.  While being gluten-free makes tests negative, you still have Celiac.  It’s like having high blood pressure.... you take medication and your blood pressure goes into the normal range - you aren’t “ cured “.  You still have high blood pressure when you stop the medications .  For a Celiac, the medication is a gluten-free diet.

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    • trents
      I would ask for a total IGA test (aka, Immunoglobulin A (IgA) and other names as well) to check for IGA deficiency. That test should always be ordered along with the TTG IGA. If someone is IGA deficient, their individual celiac IGA test scores will be artificially low which can result in false negatives. Make sure you are eating generous amounts of gluten leading up to any testing or diagnostic procedure for celiac disease to ensure validity of the results. 10g of gluten daily for a period of at least 2 weeks is what current guidelines are recommending. That's the amount of gluten found in about 4-6 slices of wheat bread.
    • jlp1999
      There was not a total IGA test done, those were the only two ordered. I would say I was consuming a normal amount of gluten, I am not a huge bread or baked goods eater
    • trents
      Were you consuming generous amounts of gluten in the weeks leading up to the blood draw for the antibody testing? And was there a Total IGA test done to test for IGA deficiency?
    • jlp1999
      Thank you for the reply. It was the TTG IGA that was within normal limits
    • trents
      Welcome to the forum, @jlp1999! Which IGA test do you refer to as being normal? TTG-IGA? Total IGA? DGP-IGA? Yes, any positive on an IGA or an IGG test can be due to something other than celiac disease and this is especially true of weak positives. Villous atrophy can also be cause by other things besides celiac disease such as some medications, parasitic infections and even some foods (especially dairy from an intolerance to the dairy protein casein). But the likelihood of that being the case is much less than it being caused by celiac disease.
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