Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Is it possible to have positive IGA antibody but negative gene tests


carollin

Recommended Posts

carollin Newbie

Are there any explanations to have positive ttg IGA antibody (6 U/ML) and at the same time, negative gene test (DQ2 and DQ8 both negative)? My son just got such test results. His doctor also said the results are confusing.


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



cyclinglady Grand Master

Hi!

I am sorry that your son is ill.  

An elevated (slightly) TTG IgA can be attributed to other illnesses.  Have those been ruled out?

Open Original Shared Link

I have not researched genes, but some of our members have an unusual variant. 

Consider asking your doctor to run a complete celiac panel (EMA and DGP). How old is your son?   

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      128,948
    • Most Online (within 30 mins)
      7,748

    GWMOOO1
    Newest Member
    GWMOOO1
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.1k
    • Total Posts
      71.4k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • CarolTN
      Thank you to Trents, Scott, Christina and Bohanley for your replies!  I have been gluten-free for about 13 years and mostly dairy-free during that time. I haven't been diagnosed as Celiac. When I did the test I hadn't eaten gluten for two years and the nurse told me the test wouldn't be accurate. Anyway, once in a blue moon I'll get tempted and take a tiny bite of something. If I do this two or three times close together, I'll get nauseated and if I don't throw up right away to stop it, will spend about 8 hours throwing up off and on before it's over.  I've been using Ketaconazole shampoo for about two years. I like T-Gel, but the prescription shampoo is the only thing right now that calms my...
    • ZandZsmom
      Are you using the same mixer that you used for your gluten containing baking? That could be your culprit.
    • trents
      I would ask for a total IGA test (aka, Immunoglobulin A (IgA) and other names as well) to check for IGA deficiency. That test should always be ordered along with the TTG IGA. If someone is IGA deficient, their individual celiac IGA test scores will be artificially low which can result in false negatives. Make sure you are eating generous amounts of gluten leading up to any testing or diagnostic procedure for celiac disease to ensure validity of the results. 10g of gluten daily for a period of at least 2 weeks is what current guidelines are recommending. That's the amount of gluten found in about 4-6 slices of wheat bread.
    • jlp1999
      There was not a total IGA test done, those were the only two ordered. I would say I was consuming a normal amount of gluten, I am not a huge bread or baked goods eater
    • trents
      Were you consuming generous amounts of gluten in the weeks leading up to the blood draw for the antibody testing? And was there a Total IGA test done to test for IGA deficiency?
×
×
  • Create New...