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Confused I Need Your Help Please

Manal

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Manal Rookie
Manal
Posted

Hello, 

What does my results mean?

tTg-IgG 8.62 
tTg-IgA 3.02 
Anti Gliadin IgA 93.24                                Anti Gliadin IgG not done                          Anti Gliadin DGP IgG 4.29

Thank You!

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tessa25 Rising Star
tessa25
Posted

Your results should include normal ranges. Can you post the ranges as well?

cyclinglady Grand Master
cyclinglady
Posted

Lab ranges do vary, but if your DGP IgA was in fact positive, you should see a Gastroenterologist to obtain biopsies via endoscopy to confirm a celiac disease diagnosis.  

I can tell you that I personally only had a positive DG IgA and the rest of the celiac blood tests were negative, yet my biopsies revealed severe intestinal damage.  

 

Manal Rookie
Manal
Posted
  • Author
  On 1/10/2019 at 3:21 AM, tessa25 said:

Your results should include normal ranges. Can you post the ranges as well?

Expand Quote  

They didn’t provide me with the normal range.

Manal Rookie
Manal
Posted
  • Author
  On 1/10/2019 at 5:16 AM, cyclinglady said:

Lab ranges do vary, but if your DGP IgA was in fact positive, you should see a Gastroenterologist to obtain biopsies via endoscopy to confirm a celiac disease diagnosis.  

I can tell you that I personally only had a positive DG IgA and the rest of the celiac blood tests were negative, yet my biopsies revealed severe intestinal damage.  

 

Expand Quote  

Which one you mean DGP IgA, is it Anti Gliadin IgA?

tessa25 Rising Star
tessa25
Posted
  On 1/10/2019 at 11:04 AM, Manal said:

They didn’t provide me with the normal range.

Expand Quote  

Lab results are useless without ranges so call your doctor and ask for a hard copy of the results. I'm guessing they just gave you a number over the phone.

cyclinglady Grand Master
cyclinglady
Posted
  On 1/10/2019 at 11:08 AM, Manal said:

Which one you mean DGP IgA, is it Anti Gliadin IgA?

Expand Quote  

Yes.  The anti-gliadin test was an older test that has been discontinued in the US.  The newer deamidated gliadin peptide (DGP) is now being used.  However, some labs just call it anti-gliadin.   It is confusing!  I suppose they did not want to type more words!   Chances are the newer test was given.  Even if the older test was given, it is still a valid test.  A little less sensitive, etc. but still good.  

Lab ranges can vary, so check with the lab or your doctor to determine a positive result.  

Learn more about the possibility of an elevated (positive) DGP  versus a TTG:

https://celiacdiseasecenter.columbia.edu/sites/default/files/Diagnostic-Yield-of-Isolated-Deamidated-Gliadin-Peptide-Antibody-Elevation-for-Celiac-Disease.pdf

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    • trents
      Awaiting diagnosis

      By trents · Posted

      I would ask for a total IGA test (aka, Immunoglobulin A (IgA) and other names as well) to check for IGA deficiency. That test should always be ordered along with the TTG IGA. If someone is IGA deficient, their individual celiac IGA test scores will be artificially low which can result in false negatives. Make sure you are eating generous amounts of gluten leading up to any testing or diagnostic procedure for celiac disease to ensure validity of the results. 10g of gluten daily for a period of at least 2 weeks is what current guidelines are recommending. That's the amount of gluten found in about 4-6 slices of wheat bread.
    • jlp1999
      Awaiting diagnosis

      By jlp1999 · Posted

      There was not a total IGA test done, those were the only two ordered. I would say I was consuming a normal amount of gluten, I am not a huge bread or baked goods eater
    • trents
      Awaiting diagnosis

      By trents · Posted

      Were you consuming generous amounts of gluten in the weeks leading up to the blood draw for the antibody testing? And was there a Total IGA test done to test for IGA deficiency?
    • jlp1999
      Awaiting diagnosis

      By jlp1999 · Posted

      Thank you for the reply. It was the TTG IGA that was within normal limits
    • trents
      Awaiting diagnosis

      By trents · Posted

      Welcome to the forum, @jlp1999! Which IGA test do you refer to as being normal? TTG-IGA? Total IGA? DGP-IGA? Yes, any positive on an IGA or an IGG test can be due to something other than celiac disease and this is especially true of weak positives. Villous atrophy can also be cause by other things besides celiac disease such as some medications, parasitic infections and even some foods (especially dairy from an intolerance to the dairy protein casein). But the likelihood of that being the case is much less than it being caused by celiac disease.
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