My Lab Results - Thoughts, Am I Clear? Feedback wanted...

[xfilesjunkie]

Hello.

I'm having a number of general health checks atm, as I've had some long standing mouth ulcers. Can't say I'm 100% convinced I have Celiac Disease, but I've had the bloods done.

The following was tested 

Deamidated Gliadin Abs (IgG)
(tTG) IgA
Endomysial Ab's (IgA)

My results came back I don't have celiac disease, but my Immunoglobulin A was slightly out of the range ( not by much).

I know a lot of people here are very experienced with testing / results - can you take a look over my results. I'm pretty sure I don't have it and they are accurate but any advice would be great.

I SHOULD NOTE. I have never in my life been gluten free and consumed it as always prior to testing.

I have attached the results as images...

 

 

[cyclinglady]

Welcome!

There are a couple of things.  First, about 10% of celiacs are seronegative.  This may apply to you.  Second, not everyone tests positive to the tests you took.  For example,  I only test positive to the DGP IgA even on follow-up tests.  If my doctor had not ordered the entire celiac panel, my diagnosis would have been missed.  Your IgA was low, but it should be enough for the IgA celiac tests to work.  

You should push for a GI consult.  Mouth ulcers could be attributed to celiac disease or another autoimmune disorder like Crohn’s.  

[xfilesjunkie]

Thanks for this reply.

Reassuring to know that while my IGA was low there was enough for a good test. 

I would appreciate any other feedback from other users....

 

THANKS!

1 hour ago, cyclinglady said:

Welcome!

There are a couple of things.  First, about 10% of celiacs are seronegative.  This may apply to you.  Second, not everyone tests positive to the tests you took.  For example,  I only test positive to the DGP IgA even on follow-up tests.  If my doctor had not ordered the entire celiac panel, my diagnosis would have been missed.  Your IgA was low, but it should be enough for the IgA celiac tests to work.  

You should push for a GI consult.  Mouth ulcers could be attributed to celiac disease or another autoimmune disorder like Crohn’s.  

 

[xfilesjunkie]

On the matter of my Immunoglobulnn A being slightly out of range, is this defo okay in terms of the test? 

 

Ive just noticed different people on here have very high ranges for Immunoglobulnn A into the 100s?

i guess they use a different range scale? 

[cyclinglady]

Your IgA result should not impact your celiac tests.  It would need to be closer to zero, but talk to your doctor.   You could always ask for the TTG IgG.  

Lab ranges vary.  Go by this lab.  

Do you have any other risk factors like anemia, other diagnosed autoimmune disorders?  

[GFinDC]

Another thing you can look at for a possible celiac indication is vitamin/mineral levels.  Celiac can impair the ability to absorb nutrients and that may show up in vitamin and mineral levels being low.  Some common ones to be low are vitamin D and B-12.  IF you were to go gluten-free for 6 months and your vitamin levels recovered it might mean there was some gut damage or other cause of malabsorption.  And the gluten-free diet helped the situation.

[xfilesjunkie]

8 hours ago, cyclinglady said:

Your IgA result should not impact your celiac tests.  It would need to be closer to zero, but talk to your doctor.   You could always ask for the TTG IgG.  

Lab ranges vary.  Go by this lab.  

Do you have any other risk factors like anemia, other diagnosed autoimmune disorders?  

Had all checked. Seems fine. My Thyroid is borderline so waiting for another follow up test to see if it’s improved. 

 

I guess im just worried as I’m a Facebook group for Celiac a few jumped on me saying it’s an invalid test due to the out of range results but then you’ve said something different but much more reassuring and in the know. 

[cyclinglady]

The link below is one example of  an IgA deficiency as it pertains to celiac disease testing your result was 0.60 :

http://clinchem.aaccjnls.org/content/54/7/1203

“Selective IgA deficiency was defined as a serum IgA concentration of <0.06 g/L in patients 2 years of age and older (5). Partial IgA deficiency was defined as a concentration ≥0.06 g/L but <2 SDs below the normal mean concentration for their age.”

http://www.cureceliacdisease.org/?s=iga&submit=Search

This above link (University of Chicago) states anything over 20 mg is fine for celiac disease testing.  Your result converted is 60.  

Any nodules or enlargement of your thyroid?  Doctors often fail to actually feel your neck during an exam!  Thyroid antibodies should be checked in my non-medical opinion of any lab results are out of range.  

[RMJ]

Your IgA was reported in grams per liter.  Those with results in the hundreds are in milligrams per deciliter.

1 g/L is 100 mg/dL.

[xfilesjunkie]

18 hours ago, RMJ said:

Your IgA was reported in grams per liter.  Those with results in the hundreds are in milligrams per deciliter.

1 g/L is 100 mg/dL.

Thanks

 

21 hours ago, cyclinglady said:

The link below is one example of  an IgA deficiency as it pertains to celiac disease testing your result was 0.60 :

http://clinchem.aaccjnls.org/content/54/7/1203

“Selective IgA deficiency was defined as a serum IgA concentration of <0.06 g/L in patients 2 years of age and older (5). Partial IgA deficiency was defined as a concentration ≥0.06 g/L but <2 SDs below the normal mean concentration for their age.”

http://www.cureceliacdisease.org/?s=iga&submit=Search

This above link (University of Chicago) states anything over 20 mg is fine for celiac disease testing.  Your result converted is 60.  

Any nodules or enlargement of your thyroid?  Doctors often fail to actually feel your neck during an exam!  Thyroid antibodies should be checked in my non-medical opinion of any lab results are out of range.  

 

 

im glad you think it’s a strong test and showing I’m not Celiac. I guess the IGG reading would have been much higher also if I had any gluten issue.