Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Any Experience with Pantoproazole?

Rhobhan
 Share

Recommended Posts

Rhobhan Apprentice
Rhobhan
Posted

I am in the eighth week of an extended reaction to gluten exposure—extreme weight loss due to diarrhea, drop in blood pressure causing dizziness.

The gastroenterologist ordered an endoscopy which showed, naturally, active celiac disease but also evidence of gastritis. He has put me on a daily dose of Pantroprazole to treat what he says was excess stomach acid, but in reading the side effects, it shows diarrhea as a common one! I was still asleep in the recovery room when he came in and gave my wife the information, so I had no chance to question him.

Has anyone had any experience with taking this medication? I believe the brand name is Protonix, a proton pump inhibitor.

 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


NNowak Collaborator
NNowak
Posted
19 minutes ago, Rhobhan said:

I am in the eighth week of an extended reaction to gluten exposure—extreme weight loss due to diarrhea, drop in blood pressure causing dizziness.

The gastroenterologist ordered an endoscopy which showed, naturally, active celiac disease but also evidence of gastritis. He has put me on a daily dose of Pantroprazole to treat what he says was excess stomach acid, but in reading the side effects, it shows diarrhea as a common one! I was still asleep in the recovery room when he came in and gave my wife the information, so I had no chance to question him.

Has anyone had any experience with taking this medication? I believe the brand name is Protonix, a proton pump inhibitor.

 

I’m sorry to hear you aren’t feeling well. My first thought when reading your post is that you wouldn’t have visible damage from just one or two accidental exposures to gluten. Inflammation below the first mucosal layer would be unlikely after only one or two accidental exposures to gluten. You need to find out the source of regular gluten ingestion/inhalation as a top priority in order to heal. 
 

I’m not a doctor, but I do know that PPIs inhibit the absorption of nutrients, such as magnesium and B12. Celiacs are known for B12 deficiency, which can also cause diarrhea, malaise, nausea, muscle pain and weakness. You need to heal your GI, not simply treat a symptom. I was on a PPI since 2007 for erosive esophagitis. In Dec 2019, I had another EDG - the esophagitis was significantly worse and I added a hiatal hernia and peptic duodenitis to the list. All of this occurred while on the prescribed PPI. The GI told my husband I needed to take a PPI, and my weight loss/malabsorption were not GI issues. ?

I’ve been on bone broth and collagen daily since September 2019, and have gained back 14 pounds. My stomach pain and diarrhea minimized with B12 injections after I was found to be deficient. Bone broth and collagen heal the mucosal membrane and promote absorption of nutrients. Kettle and Fire have good broths and soups. I also use chocolate flavored bone broth/collagen mixes from Dr. Axe because I love chocolate. 
 

You should consider seeing your general practitioner to be evaluated for nutrient deficiencies, and get to the source of your gluten exposure. Get your lab reports to discuss with your regular doctor, too. If your gluten exposure was just once, you need a doctor to look at the biopsy results to rule out refractory sprue. 
 

PPIs are not for long term treatment, so it’s important that you know what the cause is and treat it accordingly.  Again, I’m not a doctor, I’m speaking from my own experience and what I’ve learned through research. 
 

I hope you feel better soon. 

LJR1989 Apprentice
LJR1989
Posted

I've taken it recently for about 3 weeks due to what my doctor thought was excess stomach acid. It didn't really work for me (though I suspect my problem was actually low stomach acid). I had one night of really bad diarrhea and stomach pains during the time I was on it - but not sure if that was the meds or celiac or something else (I'm still not officially diagnosed with celiac... just had my positive blood work)... it happened like 2 weeks in to taking it and just once... other than that I was fine. 

 

cyclinglady Grand Master
cyclinglady
Posted

Find out what is the root cause of your Gastritis.  Your GI should provide you with the pathologist’s report.  You are entitled to all your medical records.  

In my case, I had a repeat endoscopy which showed a healed small intestine (I was doing a good job of being gluten free).  However biopsies revealed Chronic Autoimmune Gastritis (no h. Pylori) which can lead to low stomach acid.  Eventually, I could become b-12 or iron deficient.  PPIs are not prescribed for low stomach acid.  

Just adding to NNowak’s comments...?

 

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      127,924
    • Most Online (within 30 mins)
      7,748
    Vainoh
    Newest Member
    Vainoh
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.5k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Scott Adams
      How many grams is there in one slice of wheat bread?

      By Scott Adams · Posted

      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
      Confused with test results

      By Scott Adams · Posted

      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
    • MaryMJ
      Water filters and gluten

      By MaryMJ · Posted

      I called zero water and they state their filters do not contain gluten or gluten containing ingredients. 
    • trents
      What should I do with these test results?

      By trents · Posted

      I agree. Doesn't look like you have celiac disease. Your elevated DGP-IGG must be due to something else. And it was within normal at that after your gluten challenge so it is erratic and doesn't seem to be tied to gluten consumption.
    • Jack Common
      How many grams is there in one slice of wheat bread?

      By Jack Common · Posted

      Hello! I want to share my situation. I had symptoms like some food intolerance, diarrhea, bloating, belching one year ago. I thought I could have celiac disease so I did the blood tests. The results were ambiguous for me so I saw the doctor and he said I needed to do tests to check whether I had any parasites as well. It turned out I had giardiasis. After treating it my symptoms didn't disappear immediately. And I decided to start a gluten free diet despite my doctor said I didn't have it. After some time symptoms disappeared but that time it wasn't unclear whether I'd had them because of eliminating gluten or that parasite. The symptoms for both are very similar. Giardiasis also damages the small intestine. The only way to check this was to start eating bread again as I thought. Now about my results.   These are my first test results (almost a year ago) when I had symptoms: The Tissue Transglutaminase IgA antibody - 0.5 U/ml (for the lab I did the tests 0.0 - 3.0 is normal) The Tissue Transglutaminase IgG antibody - 6.6 U/ml (for the lab I did the tests 0.0 - 3.0 is normal) Immunoglobulin A - 1.91 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) IgA Endomysial antibody (EMA) - < 1:10 titer (for the lab I did the tests < 1:10 titer is normal) IgG Endomysial antibody (EMA) - < 1:10 titer (for the lab I did the tests < 1:10 titer is normal) Deamidated gliadin peptide IgA - 0.3 U/ml (for the lab I did the tests 0.0 - 6.0 is normal) Deamidated gliadin peptide IgG - 46.1 U/ml (for the lab I did the tests 0.0 - 6.0 is normal)   Then I didn't eat gluten for six months. Symptoms disappeared. And I started a gluten challenge. Before the challenge I did some tests. My results: The Tissue Transglutaminase IgG antibody - 0.5 U/ml (for the lab I did the tests < 20 U/ml is normal)) Deamidated gliadin peptide IgG - 28 U/ml (for the lab I did the tests < 20 U/ml is normal)   During the challenge I ate 6 slices of wheat bread. After the challenge my results are: The Tissue Transglutaminase IgA antibody - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) The Tissue Transglutaminase IgG antibody - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) Immunoglobulin A - 1.31 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) Deamidated gliadin peptide IgA - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) Deamidated gliadin peptide IgG - 2.13 U/ml (for the lab I did the tests < 20 U/ml is normal)   To be sure I continued consuming gluten. I ate a lot each day. Two months after I did the tests again. My results I got today are: The Tissue Transglutaminase IgA antibody - 0.7 U/ml (for the lab I did the tests < 20 U/ml is normal) Immunoglobulin A - 1.62 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) Deamidated gliadin peptide IgG - 25.6 U/ml (for the lab I did the tests < 20 U/ml is normal)   Nowadays I didn't have any symptoms except tiredness but I think it's just work. I think it was this parasite because two years ago, for example, and before I didn't have these symptoms and I always ate gluten food. But I'm still not sure especially because the Deamidated gliadin peptide IgG results are sometimes high. What do you think? @Scott Adams
×
×
  • Create New...