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    1. - trents replied to KCGirly's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
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    4. - knitty kitty replied to Mnofsinger's topic in Related Issues & Disorders
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    • trents
      Well, I strongly disagree that it was a comprehensive celiac disease panel. In addition to the tTG-IGA and the Immunoglobulin A, a comprehensive celiac panel would have included DGP-IGA, DGP-IGG and TTG-IGG. What he ordered was the most popular celiac antibody test available (and perhaps the best one), the tTG-IGA and he also, to his credit, ordered the Immunoglobulin A (aka, "total IGA"). The total IGA test is not a celiac antibody test per se but is used to check for IGA deficiency. IGA deficiency can distort IGA test results for individual IGA test scores downward and create false negatives. You are not IGA deficient so that is not a problem in your case. Here is an article giving an overview of celiac antibody testing:   
    • knitty kitty
      Welcome to the forum, @KCGirly, In addition to side effects like rashes and gastrointestinal symptoms, Semaglutide is known to cause Thiamine Vitamin B1 deficiency.   Gastrointestinal Beriberi (a Thiamine deficiency disorder) causes nausea, vomiting, abdominal pain, diarrhea, constipation, and tachycardia.   Consuming a diet high in carbohydrates (like during a gluten challenge) can make symptoms worse.  Thiamine is needed to convert carbs, fats, and proteins into energy and enzymes that keep us alive.  Without sufficient thiamine, our bodies store excess calories as fat. Symptoms of thiamine deficiency can wax and wane depending on how much dietary thiamine is consumed.  If you eat a meal with lots of thiamine (meat and liver are good sources of dietary thiamine),  a twenty percent increase in dietary thiamine produces an eighty percent increase in brain activity and symptoms improve.  Symptoms can occur for years with subclinical thiamine deficiency. A doctor can administer high dose thiamine intravenously, or over-the-counter thiamine supplements (Benfotiamine) can be taken.  Symptoms improve within a few hours to days with thiamine supplementation.  Thiamine is safe and nontoxic even in high doses.  No harm in trying thiamine supplementation, if only to rule it out.  Unfortunately, many doctors are not aware of thiamine deficiency caused by pharmaceuticals.   Thiamine deficiency can affect antibody production and results in false negatives on Celiac testing. Semaglutide can also cause Vitamin B12 deficiency and folate deficiency.  Anesthesia can also deplete B12. Do keep us posted on your progress.
    • KCGirly
      Thanks for the reply Trent.  You asked how much gluten I’m consuming daily.  I haven’t been tracking that.  I just know that some of the food I’ve been eating does have gluten like sandwiches and things like that.  I’ve also had a few cookies we baked that had flour.    My GI doctor did get back with me and they are moving the endoscopy up to tomorrow.  I too hope I have consumed enough gluten for the test to be accurate.    The odd thing about this is about 12-14 years ago I had similar symptoms.  The ended up diagnosing as IBS.  They never did celiac testing.  The episodes went away and just reared their ugly head again this year. I’m not sure why they just stopped, but was thankful.   Here are the results for the blood test. CELIAC DISEASE COMPREHENSIVE PANEL INTERPRETATION No serological evidence of celiac disease. tTG IgA may normalize in individuals with celiac disease who maintain a gluten-free diet. Consider HLA DQ2 and DQ8 testing to rule out celiac disease. Celiac disease is extremely rare in the absence of DQ2 or DQ8. Show Less TISSUE TRANSGLUTAMINASE AB, IGA U/mL <1.0 IMMUNOGLOBULIN A 230
    • knitty kitty
      Foods tasting salty can be an indicator of diabetes, kidney failure, Sjogren's syndrome, thyroid problems, smoking, dehydration and zinc deficiency.  
    • trents
      Our insight into the immune responses involved in celiac disease has steadily increased and there have been many attempts to develop drug therapies to either break down gluten before it triggers immune system responses or to, in some way, trick the immune system into no longer identifying gluten as a threat. So far, all these attempts have been disappointments that did make it out of the trial phases that all new drug therapies are put through.
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