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Celiac.com Article:Ode to Gluten-Free Fish and Chips

Jefferson Adams

By Jefferson Adams
in Publications & Publicity

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Jefferson Adams Grand Master
Jefferson Adams
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    • Katya773
      Previous Biopsy Results

      By Katya773 · Posted

      Hi thank you so much for your input. It’s been very difficult to navigate this whole Celiac thing with everything that’s happened. What you said makes sense. I  have a better understanding of how my doctors NP was able to give me a diagnosis.  Yes I agree that staying gluten-free is best, I’ve been doing some research and it seems like DQ 2.5 homozygous does make folks extra sensitive to gluten even without a celiac diagnosis. My new gastroenterologist put me in touch with a nutritionist but I’ll have to inquire if they specialize in Celiac. Appreciate the advice 🙏🏼 
    • trents
      6 week challenge; How much gluten?

      By trents · Posted

      Okay, then. It definitely looks like TTG-IGA to me and your score far exceeds the 10x or greater that is becoming the new standard for official celiac disease diagnosis criteria without biopsy.  Talk to your physician about this.  
    • Pinkdoglady
      6 week challenge; How much gluten?

      By Pinkdoglady · Posted

      Thank you the reference range was 0.1 to 3.9
    • trents
      6 week challenge; How much gluten?

      By trents · Posted

      Do you have a reference range for the Serum Tissue Transglutimate? Different labs used different reference ranges so just giving the raw score of >100 is necessarily helpful. And the terminology they employed for that one is unusual. So, I'm not sure if they are referring to what we call "total IGA" or what we abbreviate normally as TTG-IGA? I think it is the latter and the "greater than" symbol suggests it exceeded the scale they were using. If I'm correct in this assumption, that is a very strong indicator of celiac disease and may qualify you for an official diagnosis without an endoscopy/biopsy. It is becoming increasingly common in Europe and the UK to declare an official diagnosis of celiac disease when the TTG-IGA score is 10x normal or greater. But that aside, your endomysial antibody IGA is positive and that is the most accurate test available for celiac disease. It's a more expensive test to run and isn't run as often as it used to be. It has largely been replaced with the TTG-IGA. There is no question in my mind that you have celiac disease. You might want to confer with your physician for greater clarity as well as options.  
    • trents
      TTG-IGA Question

      By trents · Posted

      Welcome to the forum, @alannahP! Excellent question but I don't know that I have ever seen any TTG-IGA score be "0". But then again, I only see TTG-IGA scores of people who have celiac disease. It would be interesting to know if people who don't have celiac disease would necessarily have a "0" TTG-IGA score or if a very low TTG-IGA score is normal for non celiacs. In other words, is a little TTG-IGA antibody count normal as part of the total IGA antibody immune spectrum? We also know that elevated TTG-IGA scores can be caused by some other health issues since it is less than 100% specific. I would be careful here not to obsess over this.
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