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Questions About Entrolab?


Lollie

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Lollie Enthusiast

I've read alot about tesing and entrolab keeps coming up.... I'm wondering if you have already gone gluten-free will the test still be accurate? I really don't want to go back on gluten, the diet has shown me there is a definant correlation and i'd rather not be sick again. :unsure: But at the same time, a Dx would be helpful when I'm weak. ;) I did get blood tests done prior to going gluten-free, but my doctor sent a letter saying I was normal....

I just don't know, other than that I feel better with no gluten.

Any comments would be great!

-Lollie


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Lollie Enthusiast

I accidentally, spelled Enterolab wrong.... my bad!

-Lollie ;)

Nancym Enthusiast

Enterolab can detect the antibodies for quite awhile after being gluten free. I had been gluten-free for about 3 months. And, of course, the DNA test isn't dependent on eating anything.

Lollie Enthusiast

Will it tell you if your just intolerant-or is it just indicative of celiac.

And is it expensive? I undersood that it is something you do your self? I guess I still have lots of questions!

Lollie

dlp252 Apprentice
Will it tell you if your just intolerant-or is it just indicative of celiac.

And is it expensive? I undersood that it is something you do your self? I guess I still have lots of questions!

Lollie

I'd say it's expensive, I got almost all the tests so it cost around $400 with shipping. It definitely told me I was intolerant and since I also bought the gene testing as well, it told me I have one of the main genes associated with Celiac...that was enough for me. That cemented in my mind that I can never eat gluten again without suffering the consequences. The treatment for intolerance is the same as for Celiac in any case. You order the tests from them, they express it out to you. The gene test is done with a swab on the inside of your cheek. The others are done with a stool test which you collect in a special container. They include all the shipping materials to sent it back to them. They run the analysis and a doctor interprets the tests, then they email the results back to you.

Lollie Enthusiast

$400 doesn't sound so bad, if I hadn't already spent $400+ to my doc to do testing....I don't know if he even knew what to look for! <_<

Thanks for getting back to me! I guess I'll look them up on the net and see about taking care of it....And I can stay gluten-free?

-Lollie

Guest barbara3675

Donna has done a very good job of explaing the Enterolab process to you. I did it and had been gluten-free for a while too. They got the results back to me within two weeks via email. I consider it a well spent $400 and will never eat gluten again. I do not have celiac disease/I have a gluten intolerance, but I do have a gene. I could develop full-blown celiac disease somewhere down the line if I would not eat gluten-free, and I have a granddaughter that has celiac disease. It is thought that the method of testing that Enterolab does will eventually be the gold standard for gluten intolerance and celiac testing as it is much more sensitive than testing through the blood. Barbara


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Lollie Enthusiast

Thanks! I'm going to give it a try! I appreciate all of you responding!

-lollie

Rachel--24 Collaborator

Good luck!!

I got tested after 4 months off gluten and was positive in all areas but with no Celiac gene. I have 2 intolerance genes. Enterolab cannot offically diagnose Celiac...it will just tell you if you're immune system is responding negatively to gluten and if you posess the gene to develop Celaic or not.

dlp252 Apprentice
$400 doesn't sound so bad, if I hadn't already spent $400+ to my doc to do testing....I don't know if he even knew what to look for! <_<

Thanks for getting back to me! I guess I'll look them up on the net and see about taking care of it....And I can stay gluten-free?

-Lollie

You're welcome! I feel my $400 was money well spent. I had been on a low carb diet for about 2 years so I doubt the standard blood tests and biopsies would have shown much. I'd been gluten free for a few weeks before I sent for my Enterolab tests. Their website says you can be gluten-free for up to a year I believe.

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    • Scott Adams
      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
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    • Jack Common
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