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LabCorp Celiac Disease Comprehensive Panel - Test Results


kidprodigy

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kidprodigy Rookie

I had serology testing re-run recently via LabCorp's Celiac Disease Comprehensive Panel and the lab test results are attached.

Unless the duodenal biopsy results from my upper endoscopy procedure show otherwise, it doesn't seem likely that I have Celiac disease.  Agreed?

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cyclinglady Grand Master

Agreed.  But there is a percentage of celiacs who are seronegative.  It is up to 15%.  So, there is still a possibility.  

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      In a person with celiac disease, the consumption of gluten causes an inflammatory response in the villous lining of the small intestine. This inflammatory response produces antibodies that can be detected by blood tests. When you withdraw gluten from the diet, the inflammation subsides and the antibodies in the blood begin to disappear and after a certain period of time they will drop below levels that can be detected by the tests. Same with biopsy. The inflammation caused by gluten consumption wears down the villous lining and damages it. When you withdraw gluten the inflammation ceases and the lining begins to heal. If enough time passes and healing is significant, there is no damage to see from the biopsy.
    • plumbago
      I was drafting a reply when trents' reply came in, and I concur with everything he says. I was going to say, @jayjays that, based on what you wrote, it seems that the sequence of testing events was not correct. You need to still be eating gluten even for the blood tests. If your goal is to find out if you have Celiac, then that is what you need to do. Myself, I like knowing a diagnosis as precisely as possible. If on the other hand, you just want the misery to end in the short and medium-term, then it seems you know what to do. But after that, should any symptom return, you might not have as good an idea of what's going on as you would if you had ruled in or ruled out Celiac.
    • trents
      Welcome to the forum, @jayjays! Was the tTG-IGA the only celiac antibody test done? A more complete panel should have been ordered. Had you been eating gluten free or reduced gluten at the time of the blood draw? Your symptoms all scream of celiac disease but in order to get confirmation indeed, you would need to return to a gluten rich diet (4-6 pieces of bread daily or the gluten equivalent, i.e., 10g.) for several weeks before testing. This is true for both the blood antibody testing and the endoscopy with biopsy. Unfortunately, the UK health care system seems to be very inflexible so I'm not sure how much leverage you have in getting more complete antibody testing done. Another option would be to get your genetics checked to see if you have the potential for celiac disease. If you don't, you would need to be looking in a different direction to explain your symptoms.          
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