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TGG IgA >100

bschmidt
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bschmidt Newbie
bschmidt
Posted

A rheumatologist ran a celiac panel and called me with my results saying in his 15 years of practice he has never seen numbers this high. I am waiting for the referral to a gastro to come through. While I wait, I have been looking into why the numbers are so high with no results.  Anyone else have similar test results?  What do they mean, what’s next? 

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trents Grand Master
trents
Posted

What do you mean when you say, "I have been looking into why the numbers are so high with no results." Are you saying you have no symptoms or are you saying your research has not turned up anything? An endoscopy and biopsy of the small bowel would seem to be the next step as it is considered to be definitive for diagnosing Celiac Disease.

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Scott Adams Grand Master
Scott Adams
Posted

Many people with celiac disease don't have symptoms, yet if they keep eating gluten have the same risks as those who do have symptoms, so be sure not to let this guide your decisions regarding your test results. You should keep eating gluten and get the biopsy that your doctor recommended. If you do have celiac disease you should go gluten-free after all tests are finished.

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RMJ Mentor
RMJ
Posted

The antibody levels don’t necessarily correlate with the degree of damage or symptoms.

My TTG IgA was 143 (positive greater than 19) and I had no symptoms.

Next is a biopsy.  Keep eating gluten until the biopsy or you could get a false negative.

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  • 2 weeks later...
DJFL77I Experienced
DJFL77I
Posted

someone else had 180 here

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Amy28 Newbie
Amy28
Posted

I might be the big winner here. My test was >250! My endoscopy a few days later confirmed Stage 3.

I never had any GI issues, but I spent the better part of the summer thinking I was dizzy all the time because my new contacts were the wrong prescription or because my thyroid meds were off again.

Turns out I had a raging case of celiac.

It's been a month now and I'm mostly doing well. But spent three days this week super dizzy (ironically had gotten new contacts again) and I happened to see today that Kirkland trail mix isn't safe. I had their cheese/trail mix pack every one of those three days thinking protein would help me feel better. Whoops.

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  • 3 weeks later...
LouLou24 Rookie
LouLou24
Posted
On 10/19/2020 at 10:37 PM, DJFL77I said:

someone else had 180 here

Mine was 406 lol

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DJFL77I Experienced
DJFL77I
Posted

That's nuts.. I don't even know what mine was idiotic LabCorp only reports yo to 100... My Dr said it's definitely above 100 but since LabCorp only records up to 100 who knows . But he said the number doesn't really matter.. just getting it to drop to normal 

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RMJ Mentor
RMJ
Posted

If a lab reports >100 instead of a specific number it is because to get a specific number they would have to dilute the sample and rerun it.  

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DJFL77I Experienced
DJFL77I
Posted

What does that mean

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RMJ Mentor
RMJ
Posted
1 hour ago, DJFL77I said:

What does that mean

Tests like this give accurate numbers within a range.  There is a lower limit and an upper limit.  Each manufacturer has their own range. If the upper limit for a manufacturer is 100, anything above that will just be reported as >100.  Since that is definitely positive and antibody levels don’t necessarily correlate with the amount of damage, there is not really much use in figuring out how much above 100.  It CAN be figured out by diluting the sample.  One part serum from the patient could be mixed with one part negative serum.  Then one might get a specific number like 75, multiply by 2 and get 150.  But one still might get >100 (multiply by 2 and it would be >200).  It might take several different dilutions to get the test within the range that can give accurate numbers.  The lab doesn’t get paid any more to do that, so they don’t.

Hope this answers your question, if not, please let me know what part needs more explanation.

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