By specificity, it's not so much that elevated dgp-igg can be caused by other diseases but that it can be a false positive or a transitory immune system reaction to gluten. I believe it can also point to NCGS or a transition from NCGS to celiac disease in some cases. Some experts feel that NCGS can be a precursor to celiac disease. If biopsies are negative for celiac disease and you decide to continue with normal gluten consumption, I would have regular antibody testing done to keep an eye on those DGP-IGG levels to see if they remain high and to see if some of the IGA levels start to creep up. Elevated dgp-igg levels seem to be related in some way to an unhealthy immune system reaction to gluten. https://healthmatters.io/understand-blood-test-results/anti-deamidated-gliadin-igg-dgp-igg By the way, migraines are a common symptom of celiac disease. There is also, IMO, this misconception out there that NCGS is uncomfortable and inconvenient but not damaging to body systems and so you can be cavalier about gluten consumption if you have NCGS. I don't buy into that. I think the neat black and white categories that we have used to separate NCGS from celiac disease are doing many a disservice.

Thanks for the detailed explanation. You had mentioned that DGP-IGG might not be specific for celiac disease. Do you know what other diseases could abnormal range of DGP-IGG indicate? I'll get tests done for those diseases as well.  With respect to celiac diagnosis, I will start searching for a GI doc and get an endoscopy/biopsy done. Recently I've been having some concerning symptoms like numbness in my face, hands, and legs as well as chronic migraine. I saw a neurologist and got my brain MRI done. Nothing major was found in the MRI except some signs of migraines. I'm also having the issue of phimosis. Frustrated that we couldn't get to the bottom of what's causing numbness and headaches, I took some extensive blood work including celiac test in the effort to find the root cause and these tests were not ordered by a doctor. Not sure DGP-IGG being above range explains the numbness and headaches I have been experiencing and they could be two separate issues altogether. That's why I was curious what other disease could cause DGP-IGG to be above normal. 

Thank you so much Scott. I read your article and it was very informative. I'll find a GI doctor to review the results and get an endoscopy to confirm celiac disease. Based on my results, could it still be NCGS?

@aperlo34, Those symptoms sound awfully familiar to me.  Here's what I did for mine... I got my Vitamin D up quickly by taking Vitamin D3 supplements several times throughout the day.  High dose Vitamin D supplementation is safe and effective in raising deficient Vitamin D levels.  Aim to get your level up around 80.  Our bodies work better with Vitamin D at this level.  Vitamin D will help with mood, achy joints and depression.  Vitamin A and Vitamin D will help heal eyes and intestines. https://pubmed.ncbi.nlm.nih.gov/39125420/ I was prescribed anti anxiety meds, SSRIs.  They were a bad idea because SSRIs cause further intestinal damage.  I had such awful side effects, I had to quit taking them.     Instead, I took Tryptophan supplements.  Tryptophan is needed to make serotonin, the feel good neurotransmitter.  Without enough serotonin, we feel anxious.  Tryptophan is important for intestinal health and our intestinal bacteria.  We get tryptophan (and Niacin) from our diet.  Our body can make tryptophan from Niacin Vitamin B 3.  In celiac disease, we may not be absorbing sufficient amounts of Niacin and the other water soluble B vitamins.  I took my B Complex twice a day with meals.  I took a Tryptophan supplement at bedtime.  I found adding a Lysine supplement helpful in reducing anxiety.  Lysine is an amino acid found in lots of foods like meats.  Lysine helps with intestinal health and improves serotonin use in the body.  Serotonin, besides improving mood, also stimulates tear production!!!  Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis https://pmc.ncbi.nlm.nih.gov/articles/PMC4728667/ And... Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor https://pmc.ncbi.nlm.nih.gov/articles/PMC5537296/ And... l-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats https://pmc.ncbi.nlm.nih.gov/articles/PMC307574/ I also take Benfotiamine, a form of Thiamin Vitamin B 1, shown to promote healing in the gastrointestinal tract.  Supplementing with Benfotiamine improves anxiety and helps heal the intestines and improves brain function.  Benfotiamine needs magnesium to work properly, so I take Magnesium Threonate, a form of magnesium which gets into the brain easily and helps immensely with anxiety and thinking.  Niacin and thiamine with riboflavin and pyridoxine are used to make enzymes and energy for all healing we're going through. Magnesium and calcium can be pulled out of our bones to keep our blood levels stable.  Containing both of these minerals, broccoli and leafy greens, like kale and collards, are great for the Celiac diet. Hope this helps!   Happy Holidays!

B-Complex B-12 1000mg (methyl sublingual) CoQ10 100mg D 3000iu  Centrum Men's Multivitamin Magnesium 400mg Omega 3 2000mg My latest labs were: D - 43.6 (range 30-100) B12 - 406 (range 232-1245) Folate - 11.4 (range >3.0) ferritin - 117 (30-400) magnesium - 2.3 (1.6-2.3) Calcium - 9.9 (8.7-10.2) My symptoms are currently - these all come and go except the dry eyes have been for a couple of months now: Joint aching (mostly knuckles), muscle twitches, now apparently dry eyes.  I'm considering looking into anxiety medication, the past 4 months have been horrible for me. I can't tell what is a real symptom anymore and what is just my mind.