Fatigued all the time

[HopeMoore]

I’ve had Celiac disease for over 5 years. I watch what I eat and all that. I did feel better at first but now I am tired ALL the time. I feel like I am dehydrated. I drink water all the time. Sometimes Gatoraide helps me feel better. Also in past few months constipation is awful. I have to take 2 weeks of laxatives to have a BM. It’s like my there’s no movement in my gut. Anyone else have problems like this? I have tried everything I know.

[GFinDC]

3 minutes ago, HopeMoore said:

I’ve had Celiac disease for over 5 years. I watch what I eat and all that. I did feel better at first but now I am tired ALL the time. I feel like I am dehydrated. I drink water all the time. Sometimes Gatoraide helps me feel better. Also in past few months constipation is awful. I have to take 2 weeks of laxatives to have a BM. It’s like my there’s no movement in my gut. Anyone else have problems like this? I have tried everything I know.

Might be a good idea to have your A1C tested for possible T-2 diabetes.

[trents]

It also may be a good idea to get and endoscopy and a colonoscopy. The loss of motility in your gut is nothing to take lightly and can have a number of causes including Crohn's disease. As GFinDC mentioned, you need to get checked for diabetes as well. The constant thirst can be symptomatic of diabetes.

[cristiana]

Hello Hope

I agree with all the above.  But also see if you can have your vitamin D, vitamin B12 and also iron levels checked. Deficiencies in these can cause fatigue.

Cristiana

[Susie0402]

2 hours ago, HopeMoore said:

I’ve had Celiac disease for over 5 years. I watch what I eat and all that. I did feel better at first but now I am tired ALL the time. I feel like I am dehydrated. I drink water all the time. Sometimes Gatoraide helps me feel better. Also in past few months constipation is awful. I have to take 2 weeks of laxatives to have a BM. It’s like my there’s no movement in my gut. Anyone else have problems like this? I have tried everything I know.

I've had celiac disease for one year.  I am exhausted all the time and have added water to my everyday diet.  Coffee was a big addiction and now I have 2 cups.  Metamucil has been fabulous in keeping me regular.  The NP in my GI doctor's office suggested this and it works like a charm.  I've had both shots (Pfizer) and after 5 days for both shots, I got very cold, swollen lymph glands in my neck, and was wiped out.  Glad I'm vacced up!!  Good luck to you!!

 

[HopeMoore]

9 hours ago, trents said:

It also may be a good idea to get and endoscopy and a colonoscopy. The loss of motility in your gut is nothing to take lightly and can have a number of causes including Crohn's disease. As GFinDC mentioned, you need to get checked for diabetes as well. The constant thirst can be symptomatic of diabetes.

Yes I haven’t been to a GI in awhile.

[Posterboy]

On 4/14/2021 at 10:47 AM, HopeMoore said:

I’ve had Celiac disease for over 5 years. I watch what I eat and all that. I did feel better at first but now I am tired ALL the time. I feel like I am dehydrated. I drink water all the time. Sometimes Gatoraide helps me feel better. Also in past few months constipation is awful. I have to take 2 weeks of laxatives to have a BM. It’s like my there’s no movement in my gut. Anyone else have problems like this? I have tried everything I know.

HopeMoore,

Taking some Magnesium Glycinate and or Magnesium Citrate with Benfotiamine (a fat soluble B1)  with meals will help your fatigue.

Here are two great studies about it....One on Magnesium and one on Thiamine.

Entitled "Red blood cell magnesium and chronic fatigue syndrome"

https://www.thelancet.com/journals/lancet/article/PII0140-6736(91)91371-Z/fulltext

And this one on Thiamine and Chronic Fatigue.

Entitled "Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study"

https://pubmed.ncbi.nlm.nih.gov/23379830/

If these don't help you.....search Celiac.com for Magnesium or Thiamine and many threads will come up about it.

I hope this is helpful but it is not medical advice.

Posterboy,

 

[HopeMoore]

On 4/14/2021 at 12:00 PM, trents said:

It also may be a good idea to get and endoscopy and a colonoscopy. The loss of motility in your gut is nothing to take lightly and can have a number of causes including Crohn's disease. As GFinDC mentioned, you need to get checked for diabetes as well. The constant thirst can be symptomatic of diabetes.

Yes I haven’t been to a GI in awhile.

[Kate333]

Are you getting enough fiber in your diet?   Enough sleep and exercise?  Ask your GI about SIBO/IBS.  All of these can effect digestion... 

You might also consider that fatigue (and digestion) issues are often classic physical symptoms of chronic depression/anxiety/insomnia, quite understandable to spike during this pandemic.  That's certainly been the case for me.

An excellent source of info. that explains in detail how our (anxious, worried) minds affect our body functions is Anxietycentre.com.  If your labs all check out (including thyroid function and an updated TTG-IGA), then you might ask your primary doc for a low dose antidepressant and/or referral to a counselor to help you through this difficult time in your life.  Also, I noticed an improvement in my mood when I cut down on Dr. Google and avoided all "news" (most of which is hyped and negative)

Good luck on your healing journey!

 

[knitty kitty]

"Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/

 

"A number of studies have shown an inverse association between thiamine levels and symptoms of depression in adults."

[knitty kitty]

And another....

"The Role of Vitamins and Minerals in Psychiatry"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046018/#!po=2.30769

[HopeMoore]

17 hours ago, Posterboy said:

HopeMoore,

Taking some Magnesium Glycinate and or Magnesium Citrate with Benfotiamine (a fat soluble B1)  with meals will help your fatigue.

Here are two great studies about it....One on Magnesium and one on Thiamine.

Entitled "Red blood cell magnesium and chronic fatigue syndrome"

https://www.thelancet.com/journals/lancet/article/PII0140-6736(91)91371-Z/fulltext

And this one on Thiamine and Chronic Fatigue.

Entitled "Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study"

https://pubmed.ncbi.nlm.nih.gov/23379830/

If these don't help you.....search Celiac.com for Magnesium or Thiamine and many threads will come up about it.

I hope this is helpful but it is not medical advice.

Posterboy,

 

What’s the difference in the two different magnesium? I have severe constipation so would I need the citrate? Sorry there is so much info it gets confusing.

[trents]

There are various forms of magnesium supplements available. They vary in how well they are absorbed. Glycinate and Citrate are the two forms that are absorbed the best. The better they are absorbed, the better they address the issue of low magnesium levels in the body and also are less likely to have a laxative effect like milk of magnesia would. But glycinate and citrate are also a little more expensive.

[Fran4]

 

On 4/14/2021 at 10:47 AM, HopeMoore said:

I’ve had Celiac disease for over 5 years. I watch what I eat and all that. I did feel better at first but now I am tired ALL the time. I feel like I am dehydrated. I drink water all the time. Sometimes Gatoraide helps me feel better. Also in past few months constipation is awful. I have to take 2 weeks of laxatives to have a BM. It’s like my there’s no movement in my gut. Anyone else have problems like this? I have tried everything I know.

I have had celiac for 5 years too and am struggling with the same thing. I am currently trying to work on the fatigue and irregularity in BM. For me what has helped is taking magnesium daily. It is really important to make sure you take it everyday just be careful if you start having laxative effects from it. If I miss a day I get backed up. Something else that helps me too is dried fruit. I keep dried apricots in my pantry and try to eat a couple everyday. For fatigue I am currently trying a B-complex and thiamin (B1). I will update how that goes but try to do some research into if you have a B vitamin deficiency. 

[Posterboy]

9 hours ago, HopeMoore said:

What’s the difference in the two different magnesium? I have severe constipation so would I need the citrate? Sorry there is so much info it gets confusing.

 

9 hours ago, Fran4 said:

For fatigue I am currently trying a B-complex and thiamin (B1). I will update how that goes but try to do some research into if you have a B vitamin deficiency. 

HopeMore and Fran Et Al,

Magnesium is a Co-Factor for Thiamine leading to Chronic Fatigue.

Taking them both together resolves most fatigue issues!

I had this problem once.....you can get better.

See this research about it...

Entitled  "Thiamine refractory Wernickes encephalopathy reversed with magnesium therapy"

Where they note quoting....

"Magnesium is an essential cofactor of an enzyme in the pentose phosphate pathway, transketolase, whose activity is decreased in thiamine deficiency. Hypomagnesaemia may result in thiamine refractoriness"

Magnesium Glycinate is the easiest form to take but you shouldn't worry about taking Magnesium Citrate as a liquidgel or capsule or tablet with meals.

When you exceed approx. 200mg of Magnesium Citrate (especially on an empty stomach) Magnesium Citrate can cause a mild laxative effect known as the "Magnesium Flush" which is the urge for a bowel movement approx. 20 to 30 minutes after consuming Magnesium Citrate in a powdered form (Like Natural Calm Natural Vitality powder) or as a concentrate liquid sold for it's laxative ability.

HopeMoore you can take more than one kind of Magnesium if you prefer.

Magnesium Oxide will help with Constipation but it is not well absorbed and will not help Fatigue!

See this great article on the many types of Magnesium and which kinds are best!

https://www.dietvsdisease.org/best-magnesium-supplement/

I will quote a few things from it....so it will be easier to digest....

quoting

"Once ingested magnesium oxide is poorly absorbed by the body (approximately three-fold less than magnesium citrate). Only around 4% of its elemental magnesium is absorbed, equivalent to roughly 9.5 mg out of a 400 mg tablet (with 60% elemental magnesium).

Its low intestinal bioavailability means it often causes diarrhea, and is actually often used for laxatative purposes (8).

Use of this in a magnesium supplement may mean the manufacturer is cutting costs."

And their explanation of Magnesium Citrate

Quoting again....

"Magnesium citrate appears to be quite well-absorbed by the body; that is, it has a bioavailability of 25-30%.

As it mixes well with liquids, and is low cost, magnesium citrate is the most common type of magnesium supplementation." And one of the best type for the money you can buy IMHO.

Magnesium Glycinate can be on the expensive side....but it does not cause diarrhea and can really help fatigue and muscle cramps!

For the Vitamin B1 find a FAT Soluble form like Benfotiamine or Allithiamine or Lipothiamine etc...

For both Magnesium and Thiamine form matters!

See this article about the Fat Soluble forms like Benfotiamine have a much higher Bioavailabiity than those in Multivitamin or B-Complex.

Entitled "Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride" as seen on the label as ThiamineHCL.

quoting from the abstract....

"Compared to thiamine hydrochloride, the bioavailability of thiamine in plasma and TDP in erythrocyte after oral administration of benfotiamine were 1147.3 ± 490.3% and 195.8 ± 33.8%, respectively. The absorption rate and extent of benfotiamine systemic availability of thiamine were significantly increased indicating higher bioavailability of thiamine from oral dose of benfotiamine compared to oral dose of thiamine hydrochloride."

But this is only true if you take it with meals the fat aids absorption. And preferentially with a Magnesium Glycinate or Magnesium Citrate!

Magnesium literally changed my life!

I hope this is helpful but it is not medical advice.

Posterboy,

 

[cristiana]

Hope, I'm no expert on magnesium but I always make sure I have some in the house.  If I get a bit constipated I find just one-two tablets gets things back to normal again, but it's important to drink plenty of water.  The other thing is for many years I've suffered from occasional spates of twitches under my eyes, which I find very distracting, and sometimes other muscles, and a couple of days of magnesium makes all the difference.   This is something I learned from this forum early on after my diagnosis, what a blessing as I seemed to have a lot of twitching back then.

[HopeMoore]

12 hours ago, Posterboy said:

 

HopeMore and Fran Et Al,

Magnesium is a Co-Factor for Thiamine leading to Chronic Fatigue.

Taking them both together resolves most fatigue issues!

I had this problem once.....you can get better.

See this research about it...

Entitled  "Thiamine refractory Wernickes encephalopathy reversed with magnesium therapy"

Where they note quoting....

"Magnesium is an essential cofactor of an enzyme in the pentose phosphate pathway, transketolase, whose activity is decreased in thiamine deficiency. Hypomagnesaemia may result in thiamine refractoriness"

Magnesium Glycinate is the easiest form to take but you shouldn't worry about taking Magnesium Citrate as a liquidgel or capsule or tablet with meals.

When you exceed approx. 200mg of Magnesium Citrate (especially on an empty stomach) Magnesium Citrate can cause a mild laxative effect known as the "Magnesium Flush" which is the urge for a bowel movement approx. 20 to 30 minutes after consuming Magnesium Citrate in a powdered form (Like Natural Calm Natural Vitality powder) or as a concentrate liquid sold for it's laxative ability.

HopeMoore you can take more than one kind of Magnesium if you prefer.

Magnesium Oxide will help with Constipation but it is not well absorbed and will not help Fatigue!

See this great article on the many types of Magnesium and which kinds are best!

https://www.dietvsdisease.org/best-magnesium-supplement/

I will quote a few things from it....so it will be easier to digest....

quoting

"Once ingested magnesium oxide is poorly absorbed by the body (approximately three-fold less than magnesium citrate). Only around 4% of its elemental magnesium is absorbed, equivalent to roughly 9.5 mg out of a 400 mg tablet (with 60% elemental magnesium).

Its low intestinal bioavailability means it often causes diarrhea, and is actually often used for laxatative purposes (8).

Use of this in a magnesium supplement may mean the manufacturer is cutting costs."

And their explanation of Magnesium Citrate

Quoting again....

"Magnesium citrate appears to be quite well-absorbed by the body; that is, it has a bioavailability of 25-30%.

As it mixes well with liquids, and is low cost, magnesium citrate is the most common type of magnesium supplementation." And one of the best type for the money you can buy IMHO.

Magnesium Glycinate can be on the expensive side....but it does not cause diarrhea and can really help fatigue and muscle cramps!

For the Vitamin B1 find a FAT Soluble form like Benfotiamine or Allithiamine or Lipothiamine etc...

For both Magnesium and Thiamine form matters!

See this article about the Fat Soluble forms like Benfotiamine have a much higher Bioavailabiity than those in Multivitamin or B-Complex.

Entitled "Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride" as seen on the label as ThiamineHCL.

quoting from the abstract....

"Compared to thiamine hydrochloride, the bioavailability of thiamine in plasma and TDP in erythrocyte after oral administration of benfotiamine were 1147.3 ± 490.3% and 195.8 ± 33.8%, respectively. The absorption rate and extent of benfotiamine systemic availability of thiamine were significantly increased indicating higher bioavailability of thiamine from oral dose of benfotiamine compared to oral dose of thiamine hydrochloride."

But this is only true if you take it with meals the fat aids absorption. And preferentially with a Magnesium Glycinate or Magnesium Citrate!

Magnesium literally changed my life!

I hope this is helpful but it is not medical advice.

Posterboy,

 

Thank you so much! That explains a lot! I hope it helps!

5 hours ago, cristiana said:

Hope, I'm no expert on magnesium but I always make sure I have some in the house.  If I get a bit constipated I find just one-two tablets gets things back to normal again, but it's important to drink plenty of water.  The other thing is for many years I've suffered from occasional spates of twitches under my eyes, which I find very distracting, and sometimes other muscles, and a couple of days of magnesium makes all the difference.   This is something I learned from this forum early on after my diagnosis, what a blessing as I seemed to have a lot of twitching back then.

I have the twitching too and never thought much about it!

[HopeMoore]

12 hours ago, Posterboy said:

 

HopeMore and Fran Et Al,

Magnesium is a Co-Factor for Thiamine leading to Chronic Fatigue.

Taking them both together resolves most fatigue issues!

I had this problem once.....you can get better.

See this research about it...

Entitled  "Thiamine refractory Wernickes encephalopathy reversed with magnesium therapy"

Where they note quoting....

"Magnesium is an essential cofactor of an enzyme in the pentose phosphate pathway, transketolase, whose activity is decreased in thiamine deficiency. Hypomagnesaemia may result in thiamine refractoriness"

Magnesium Glycinate is the easiest form to take but you shouldn't worry about taking Magnesium Citrate as a liquidgel or capsule or tablet with meals.

When you exceed approx. 200mg of Magnesium Citrate (especially on an empty stomach) Magnesium Citrate can cause a mild laxative effect known as the "Magnesium Flush" which is the urge for a bowel movement approx. 20 to 30 minutes after consuming Magnesium Citrate in a powdered form (Like Natural Calm Natural Vitality powder) or as a concentrate liquid sold for it's laxative ability.

HopeMoore you can take more than one kind of Magnesium if you prefer.

Magnesium Oxide will help with Constipation but it is not well absorbed and will not help Fatigue!

See this great article on the many types of Magnesium and which kinds are best!

https://www.dietvsdisease.org/best-magnesium-supplement/

I will quote a few things from it....so it will be easier to digest....

quoting

"Once ingested magnesium oxide is poorly absorbed by the body (approximately three-fold less than magnesium citrate). Only around 4% of its elemental magnesium is absorbed, equivalent to roughly 9.5 mg out of a 400 mg tablet (with 60% elemental magnesium).

Its low intestinal bioavailability means it often causes diarrhea, and is actually often used for laxatative purposes (8).

Use of this in a magnesium supplement may mean the manufacturer is cutting costs."

And their explanation of Magnesium Citrate

Quoting again....

"Magnesium citrate appears to be quite well-absorbed by the body; that is, it has a bioavailability of 25-30%.

As it mixes well with liquids, and is low cost, magnesium citrate is the most common type of magnesium supplementation." And one of the best type for the money you can buy IMHO.

Magnesium Glycinate can be on the expensive side....but it does not cause diarrhea and can really help fatigue and muscle cramps!

For the Vitamin B1 find a FAT Soluble form like Benfotiamine or Allithiamine or Lipothiamine etc...

For both Magnesium and Thiamine form matters!

See this article about the Fat Soluble forms like Benfotiamine have a much higher Bioavailabiity than those in Multivitamin or B-Complex.

Entitled "Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride" as seen on the label as ThiamineHCL.

quoting from the abstract....

"Compared to thiamine hydrochloride, the bioavailability of thiamine in plasma and TDP in erythrocyte after oral administration of benfotiamine were 1147.3 ± 490.3% and 195.8 ± 33.8%, respectively. The absorption rate and extent of benfotiamine systemic availability of thiamine were significantly increased indicating higher bioavailability of thiamine from oral dose of benfotiamine compared to oral dose of thiamine hydrochloride."

But this is only true if you take it with meals the fat aids absorption. And preferentially with a Magnesium Glycinate or Magnesium Citrate!

Magnesium literally changed my life!

I hope this is helpful but it is not medical advice.

Posterboy,

 

What dosage of magnesium should I start with? I have some of the calm. I purchased B1 at Walgreens yesterday but they didn’t have the Benfotiamine. I also purchased Mag Citrate.

[cristiana]

Don't exceed the dose recommended on the packet, but I understand it is best to introduce it gently so your system gets used to it (and you might not need to take the maximum dose to get the required effect)   I generally only take a half dose before it kicks in, and stick at a half dose, but we're all different.

I'm not a doctor BTW so this isn't medical advice.😊

Edited April 17, 2021 by cristiana

[Posterboy]

5 hours ago, HopeMoore said:

What dosage of magnesium should I start with? I have some of the calm. I purchased B1 at Walgreens yesterday but they didn’t have the Benfotiamine. I also purchased Mag Citrate.

HopeMoore,

EnnisTx says it well for the Natural Calm "Dose to Tolerance".

Which is for most people not more than 1/2 Tsp to begin with.....

Cristiana is right even a small amount of Magnesium Citrate will make a huge difference!

Then when you see how well  you tolerate the Natural Calm powder in a couple weeks increase the dose to a full Tsp (leveled off)....

A HEAPING TSP is usually enough in the beginning to produce a "Magnesium Flush" or the urge to have a BM within the first 20 minutes.

I have actually used this method of taking extra Magnesium Citrate to help Constipation.

Magnesium is great for Constipation.  I used to have take a Stool Softener (Dulcolax) or (Peri Colace)  until I stared taking Magnesium!

The reason Magnesium can help "twitches" or Muscle Spasms is the muscles needs Magnesium to relax the muscle fiber(s)......when the muscle is over extended with the Calcium ions (the muscle can't release itself) when you take Magnesium the natural balance (Homeostasis) is restored the muscle cell and the muscle stops spasming/twitching.

It is MAGIC for Charlie Horses/Leg Cramping!'

The biggest thing is take it in divided doses IE with meals.  Never take the whole RDA at one meal.

Divided the RDA into 3 doses and don't exceed 200mg at a time and you should be fine and always with  a meal....especially for the powdered Natural Calm form.

The higher surface area of your supplement the greater chances of getting two much at one time.

So start slowly with the Powdered kinds and build up your tolerance.....but usually liquidgels, capsules or Tablets are fine....because they release the Magnesium slower....if that makes any sense!

And they are able to store smaller amounts.....amounts low enough to avoid the flushing limits unless you take more than one capsule with each meal.

If you have ever taken Magnesium before you know Magnesium Tablet's are HONKING large tablets/PIlls....so capsules are a popular option if you have trouble with the Powdered form.  BUT always with a meal is the best advice to remember to minimize any possible flushing especially when beginning any Magnesium Citrate form.

One option is to take Magnesium Citrate with your meals and Magnesium Glycinate at night to help with sleep since Magnesium Glycinate does not flush IT is safe/easy to take at night when you go too bed!

And when (If you haven't dreamed in a while) you begin dreaming again.....it a sign the Magnesium is doing you some good!

WE can reach restful REM sleep without enough Magnesium....it restores our wake/sleep balance!

I went from being Chronically Fatigue to waking up before my "Alarm Clock" had to wake me up!

I hope this is helpful but it is not medical advice.

Posterboy,

[AlwaysLearning]

Gallbladder and pancreas problems can also be involved if gut mobility is the issue. If they are not doing their jobs properly in delivering enzymes and bile, the digestive processes that are supposed to take place in the stomach don't happen and the remaining processes of moving through the rest of your bowels can be slowed down.

I would definitely research this more to determine if it sounds like this could be an issue for you. Diabetes also came to mind when I read your original post. The good news is that, if caught early, these sorts of problems can be treated simply by changing what you eat. And you can still eat quite a bit of food if you make healthy choices, so you don't have to feel deprived.

After doing a quick glance through the other posts, I would also say not to be too quick to jump on the supplement band wagon unless you have actually tested positive as being deficient in a vitamin or mineral. Most supplements have their own side effects and most are not bio identical to the nutrients you would get from a healthy diet.

Tip: epsom salt baths are an easy way to get magnesium. But too much is supposed to cause diarrhea, which is probably why people are mentioning magnesium supplements to get things moving. Its a fine line between too little and too much, just like most of life.

Yes, fiber matters, but it isn't just fiber, but the type of fiber. Some can slow things down instead of helping things move properly. And too much of the good fiber can also cause problems.

I don't think there is an easy answer to your problem as it probably is a combination of lots of factors. But until you find the answers you are looking for, I would look up daily recommended levels of things such as cholesterol, fiber, and fats and start reading your food labels and make sure your diet is giving you what you need and not too much of what you don't. It only takes two weeks to overcome a sugar addiction and no long crave sweets, and it only takes a couple days on a lower-fat diet to start sleeping better again. (Spices are the key to making healthy food taste great!)

But don't get scared reading our responses. Make sure to tell yourself the things you need to hear to believe that you can make the healthy choices needed. And as you look for answers, don't get freaked out by negative possibilities that may have nothing to do with you. Keep looking for answers until you figure out the cause, not just ways to treat the symptoms. I believe that you can and will make the healthy choices needed to improve your long-term health and that you will feel so much better for having done so!!!!