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New - please help understand blood work

mrsdelore
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mrsdelore Rookie
mrsdelore
Posted

I've attached the results I got from my Celiac panel - and it's safe to say I'm confused. LOL. Two negative results, two positive ones. The lab basically said I was low risk for Celiac, so how does that work with 2 positive results?
Symptoms: fatigue, chronic joint pain, chronic itching of scalp and just one arm/hand without any rash/redness. Have tested negative for Lyme and RA.

I'm wondering at this point if I should pursue additional testing or just start weeding out gluten and see if I feel better?

179680331_2639854932971511_4032505756648892948_n.png

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GFinDC Veteran
GFinDC
Posted
49 minutes ago, mrsdelore said:

I've attached the results I got from my Celiac panel - and it's safe to say I'm confused. LOL. Two negative results, two positive ones. The lab basically said I was low risk for Celiac, so how does that work with 2 positive results?
Symptoms: fatigue, chronic joint pain, chronic itching of scalp and just one arm/hand without any rash/redness. Have tested negative for Lyme and RA.

I'm wondering at this point if I should pursue additional testing or just start weeding out gluten and see if I feel better?

179680331_2639854932971511_4032505756648892948_n.png

It only takes one positive antibody type to do damage to your gut.  Have you talked to your GI about the results?  Generally the next step after positive blood results is an endoscopy to check for damage to the small intestine lining.  You need to keep eating gluten until all testing is complete.  So talking to your doc would be a good idea to find out if they plan to do an endoscopy and how long it will take to get scheduled.

plumbago Experienced
plumbago
Posted

Hi,

Hopefully you will be talking to the medical professional who ordered these tests! But my notes say, "If both DGP are high, celiac disease almost certain." Your doctor - or maybe others on here - may be able to tell you why the Ttg was neg but the DGP positive and what all that means. Good luck!

trents Grand Master
trents
Posted

This is a good read: https://www.niddk.nih.gov/health-information/professionals/clinical-tools-patient-management/digestive-diseases/celiac-disease-health-care-professionals

The tTG-IGA test is the most specific for celiac disease but if IGA levels are low or damage to the small bowel villi is not extensive it may be negative because it is not as sensitive as some of the other tests which are less specific for celiac disease.

 

mrsdelore Rookie
mrsdelore
Posted
  • Author
10 minutes ago, plumbago said:

Hi,

Hopefully you will be talking to the medical professional who ordered these tests! But my notes say, "If both DGP are high, celiac disease almost certain." Your doctor - or maybe others on here - may be able to tell you why the Ttg was neg but the DGP positive and what all that means. Good luck!

the test was a self requested one, but I have shared the results with my primary and am waiting to hear back from them.

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    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
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      High DGP-A with normal IGA

      By knitty kitty · Posted

      Food and environmental allergies involve IgE antibodies.  IgE antibodies provoke histamine release from mast cells.   Celiac disease is not always visible to the naked eye during endoscopy.  Much of the damage is microscopic and patchy or out of reach of the scope.  Did they take any biopsies of your small intestine for a pathologist to examine?  Were you given a Marsh score? Why do you say you "don't have intestinal damage to correlate with lifelong undiagnosed celiac disease"?   Just curious.  
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

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    • trents
      Finding gluten free ingredients

      By trents · Posted

      Welcome to the forum, @Kara S! Warrior bread is a grain free bread product. Google it. There are commercial mixes available, I believe, Youtube videos and many recipes. 
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