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Confusing results! Help

Han
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Han Rookie
Han
Posted

I received these results been am unsure what they mean. Are these normal for a person with celiac? 
 

 

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trents Grand Master
trents
Posted

I think you left something out of your post. Namely, the values themselves. We need the reference values as well to be able to know what normal range is for each test. Different labs used different reference values.

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Han Rookie
Han
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Posted

Sorry! 

Immunoglobulin A-61L (reference-70-400mg/dL)

Gliadin Deamidated Ab,IgG- <11 (reference - <15.0 U/mL)

Gliadin Deamidated Ab,IgA - <12 (reference - <15.0 U/mL)

Endomysial IgA, IFA- Positive (no reference)

Transglutaminase Ab, IgA - <12 (reference - <15.0 U/mL)

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trents Grand Master
trents
Posted

"Endomysial IgA antibody testing has a lower sensitivity than tTG IgA (positive predictive value = 79%; 95% CI, 71.0 to 85.5) and equivalent specificity. It is included in several diagnostic algorithms but is not considered a first-line test in any patient population." https://www.aafp.org/afp/2017/0601/p726.html

A very unusual test result when the Endomysial IgA is positive while the Transglutaminase (aka, tTG-IGA) is negative, since the tTG-IGA is considered to be the more sensitive test.

Had you already been on a gluten free diet prior to testing?

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Han Rookie
Han
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Posted

Yes I’ve been on a gluten-free diet for about 6 months prior to this test. 

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trents Grand Master
trents
Posted

Being on a gluten free diet for more than a week or two will likely invalidate the testing. That probably explains your odd results and so many negatives. If you want to get accurate test results you will need to be eating gluten daily for 6-8 weeks leading up to the test, consuming an amount of gluten equivalent to two slices of wheat bread daily.

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Scott Adams Grand Master
Scott Adams
Posted

Yes, your doctor should have mentioned this to you, but if you have your original results it would be interesting to compare the two tests. This would likely show how well you've adhered to a gluten-free diet. 

 

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Jan Meindfak Apprentice
Jan Meindfak
Posted
On 5/13/2021 at 3:13 AM, Han said:

Sorry! 

Immunoglobulin A-61L (reference-70-400mg/dL)

Gliadin Deamidated Ab,IgG- <11 (reference - <15.0 U/mL)

Gliadin Deamidated Ab,IgA - <12 (reference - <15.0 U/mL)

Endomysial IgA, IFA- Positive (no reference)

Transglutaminase Ab, IgA - <12 (reference - <15.0 U/mL)

Not only you should start eating some bread for some time before testing like others have already mentioned, but also I believe checking IgA class antibodies in your case is pointless since you're apparently IgA deficient. They should be redone in IgG. 

Please correct me if I'm wrong! 

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