Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Genetic Markers for Celiacs

Joshmitchell
 Share

Recommended Posts

Joshmitchell Apprentice
Joshmitchell
Posted

So, my GI ordered a test for me to see if I had the genetic markers for celiacs. I have both of the markers he tested for. My endoscopy showed no damage. And all of my bloodwork was normal including the endomysial test. The only thing that was high was my Gliadin antibody test. I never really got that sick from eating gluten. Have I just been lucky? Will I start getting damage if I continue to eat gluten? Is there any chance at all that I don’t have celiacs? Thanks. 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Scott Adams Grand Master
Scott Adams
Posted

Can you share your high blood test result along with the cut off level for celiac disease? 

If you have even one positive blood test for celiac disease, then you could still have it, or gluten sensitivity for which they currently can't screen, even though your gut isn't damaged (that could still happen later).

For your genetic test, are you saying that you're positive for both DQ2 and DQ8 genetic markers for celiac disease. If so, this puts you at mush higher risk than having just one of these markers.

Joshmitchell Apprentice
Joshmitchell
Posted
  • Author
3 hours ago, Scott Adams said:

Can you share your high blood test result along with the cut off level for celiac disease? 

If you have even one positive blood test for celiac disease, then you could still have it, or gluten sensitivity for which they currently can't screen, even though your gut isn't damaged (that could still happen later).

For your genetic test, are you saying that you're positive for both DQ2 and DQ8 genetic markers for celiac disease. If so, this puts you at mush higher risk than having just one of these markers.

IgA was 220. Standard range  is to 400
Gliadin IgA 29. Standard range is to 15

Gliadin Igg .6 standard is 15

transglutaminase IgA .5 standard is 15

Transglutaminase IGG is .8 

Endomysial was negative. 
 

And I had dq2 and dq8 markers. 

Scott Adams Grand Master
Scott Adams
Posted

So it looks like you're not IgA deficient (I believe it was 220 from what you posted), and your Anti-Gliadin IgA was positive. According to this article: "A sensitive testing protocol includes testing for both IgA and IgG anti-gliadin antibodies since a significant portion of celiac patients (approx. 2-5%) are IgA deficient. This combined IgA and IgG anti-gliadin antibody assay has an overall sensitivity of 95% with a specificity of 90%."

Generally speaking having one positive blood test for celiac disease should be enough for you to consider yourself in the gluten sensitive range (and possibly celiac disease), especially given your genetic makeup. If I were you I'd definitely consider going gluten-free, even if your doctor doesn't make this specific recommendation.

 

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      128,061
    • Most Online (within 30 mins)
      7,748
    JImG
    Newest Member
    JImG
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.6k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Scott Adams
      Celiac or Addison's complications? Can someone share their experience?

      By Scott Adams · Posted

      I also want to mention that using prednisone would likely also make the endoscopy results invalid. This steroid will cause gut healing and could mask the damage caused by celiac disease. 
    • Jess270
      Bitters for digestion?

      By Jess270 · Posted

      This sounds to me like histamine intolerance. Some foods have more or less histamine. processed or aged meats, fermented food like yoghurt or kimchi and bread (yeast), spinach, eggplant and mushroom are high in histamine. Other foods like tomatoes are histamine liberators, they encourage your mast cells to release histamine, which can also trigger the reactions you describe, flu like symptoms, joint pain, urinary tract irritation, rash, stomach upset, nausea, diarrhoea & fatigue. I had liver pain like you describe, as part of the intolerance is usually a sluggish liver that makes processing all the histamine difficult. There are multiple possible root causes of histamine intolerance, usually it’s a symptom of something else. In my case, leaky gut (damaged gut wall)caused by undiagnosed celiac, but for others it’s leaky gut caused by other things like dysbiosis. Some people also experience histamine intolerance due to mould exposure or low levels of DAO (the enzyme that breaks down histamine in the gut). I’d try a low histamine diet & if that doesn’t improve symptoms fully, try low oxalate too. As others have suggested, supplements like vitamin d, b, l-glutamine to support a healthy gut & a good liver support supplement too. If you’re in a histamine flare take vitamin c to bowel tolerance & your symptoms will calm down (avoid if you find you have oxalate intolerance though). Best of luck 
    • trents
      Vaccines

      By trents · Posted

      @GeoPeanut, milk is one of the better sources of iodine. Iodine is known to exacerbate dermatitis herpetiformis. Many people find that a low iodine diet helps them avoid dermatitis herpetiformis outbreaks. So, maybe the fact that you have limited your dairy intake of late is helping with that.
    • GeoPeanut
      Vaccines

      By GeoPeanut · Posted

      Hi, I'm new here. Sorry for your troubles.herenis a thought to mull over. I recently was diagnosed with celiac disease,  and hashimoto's and dermatitis herpetiformis after getting covid 19. I eat butter, and 1/2 cup of Nancy's yogurt daily. I stopped all other dairy and  dermatitis herpetiformis is gone! I also make grass fed beef bone broth to help with myopathy that has occurred. 
    • trents
      Celiac or Addison's complications? Can someone share their experience?

      By trents · Posted

      Welcome to the forum, @KRipple! Sorry to hear of all your husband's health problems. I can only imagine how anxious this makes you as when our spouse suffers we hurt right along with them. Can you post the results from the Celiac blood testing for us to look at? We would need the names of the tests run, the numeric results and (this is important) the reference ranges for each test used to establish high/low/negative/positive. Different labs use different rating scales so this is why I ask for this. There aren't industry standards. Has your husband seen any improvement from eliminating gluten from his diet? If your husband had any positive results from his celiac blood antibody testing, this is likely what triggered the consult with a  GI doc for an endoscopy. During the endoscopy, the GI doc will likely biopsy the lining of the small bowel lining to check for the damage caused by celiac disease. This would be for confirmation of the results of the blood tests and is considered the gold standard of celiac disease diagnosis. But here is some difficult information I have for you. If your husband has been gluten free already for months leading up to the endoscopy/biopsy, it will likely invalidate the biopsy and result in a false negative. Starting the gluten free diet now will allow the lining of the small bowel to begin healing and if enough healing takes place before the biopsy happens, there will be no damage to see. How far out is the endoscopy scheduled for? There still may be time for your husband to go back on gluten, what we call a "gluten challenge" to ensure valid test results.
×
×
  • Create New...