Could Celiac Disease be triggered by a Low B-Vitamin State? New Research shows your Biome and/or Microbiome can predict the Onset of Celiac disease 18 months before your Celiac diagnosis?

[Posterboy]

To Whom Ever Might Read This,

This is triggered by some research Scott shared with me.

Entitled "With age, insufficient tryptophan alters gut microbiota, increases inflammation"

https://www.eurekalert.org/pub_releases/2021-06/mcog-wai062321.php

And the very recent research I came across that shows Celiac disease (by monitoring our Microbiome) can be predicted up to 18 months in advance.....

(Which I believe Scott will summarize soon as an article soon).....but this thread is more about the recent research I rediscovered on how LPS production triggering a Leaky gut can be triggered by Low B-Vitamins....and the accompanying research showing how each of the B-Vitamins (B1, B2, B3) play a role in controlling LPS production in our GI Tract...

Entitled "Changes in gut microbiome in longitudinal study of infants precede onset of celiac disease"

https://medicalxpress.com/news/2021-07-gut-microbiome-longitudinal-infants-onset.html

18 months in advance of a Celiac diagnosis is much earlier than you would suspect if Celiac disease is a 100 percent genetic disease (as they mused) surprising the researchers....but if SIBO or LPS production is the trigger for a leaky gut then.....it is what one might conclude if Low B-Vitamins are or could be the trigger.....what one might theorize...that your microbiome is triggering a Leaky gut.....(and why I have always  argued that Celiac disease (and/or SIBO) if you believe SIBO can be a trigger for Celiac disease is a 50/50 proposition.....of your environment (IE Low B-Vitamins) affecting your genes...

Proving to me, at least, that the genetic Celiac disease has an environment trigger....triggered, in part, by Low B-Vitamins.

Here is the research that shows how B-Vitamins (B1 (Thiamine), B2 (Riboflavin) and B3 (Niacin) specifically) are involved in the regulation of LPS production in our GI tract leading, in time, to not only a Leaky Gut,  but both SIBO and Celiac disease IMHO.

For those who don't know or haven't studied it Liposaccharide aka LPS (and hereafter abbreviated LPS) is the portion of bacteria (known as a Endotoxin) thought to lead to a Leaky Gut in patients with SIBO....

The below research shows how Tryptophan, B1, B2 and B3 help down regulate the toxicity of LPS leading, in time, and with high enough (amounts) the  toxicity (from LPS)  can result in a Leaky Gut triggered by our Microbiome....

If low in any of these Vitamins or metabolites then you can develop SIBO and a leaky gut.....IMHO

See this research entitled "Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide (LPS)induced cytotoxic signals in murine macrophages"

https://pubmed.ncbi.nlm.nih.gov/20219672/

See this research entitled "Riboflavin (aka Vitamin B2) protects mice against liposaccharide (LPS) induced shock through expression of heat shock protein 25"

https://www.sciencedirect.com/science/article/abs/pii/S0278691510002474

See this research entitled "Niacinamide is a potent inhibitor of proinflammatory cytokines"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808598/

This would explain why Tryptophan has recently been shown to help heal Villi in Celiac's....

https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx

If any of these is true.....then it will take another 15 to 20 years (sadly) for the medical community to "Catch UP" with this latest medical research.

The research on Niacin alone is 18+ years old.....

And why they only "theorized" this.....much more recent research I found is less than 5 year old.....confirming these findings (as well as the new Tryptophan research)

Entitled "Niacin (aka Niacinamide or Vitamin B3) and its metabolites as master regulators of Macrophage activation"

https://www.sciencedirect.com/science/article/abs/pii/S0955286316302960

Where they note "This study reveals for the first time that niacin and its metabolites possess antioxidant, reprogramming and antiinflammatory properties on human primary monocytes and monocyte-derived macrophages."

Which if the above research on B-Vitamins is correct trigger a Leaky gut when all these B-Vitamins (B1, B2, B3 and Tryptophan) get low and we get over run with the LPS endotoxin common in SIBO and other leaky gut syndrome(s) which include Celiac disease....etc.

We now SIBO can be trigger for Celiac disease because people still struggling on a gluten free diet get better once their SIBO has also been treated.

See this article about this topic...

They concluded quoting...

"The researchers conclude that SIBO affects most celiacs who have persistent gastrointestinal symptoms after going gluten-free."

My argument is to treat the underlying trigger for Both.....Low B-Vitamins!

I welcome anyone's feedback and insights?

I hope this is helpful but it is not medical advice.

Posterboy,

[Scott Adams]

One question I have is which comes first? Does a virus that might trigger celiac disease in someone with the genetic propensity for it cause malabsorption, which then causes issues absorbing B vitamins and other nutrients that leads to a cascade of different symptoms? Or, absent any gut damage, would low B vitamins be a trigger of celiac disease. 

In your model I’m not sure how the initial low vitamin state comes about. It seems like it would come later, after a viral trigger.

[knitty kitty]

Scott,

The initial low vitamin state may come about because of several factors.  

High calorie malnutrition:

A diet high in carbohydrates and not enough nutrients from other dietary sources can lead to vitamin insufficiencies.  The Standard American Diet is high in carbohydrates and fats, both of which require thiamine to change them into energy.  Without enough thiamine to turn carbohydrates into energy, the body uses a thiamine saving shortcut, storing the carbs as fat, usually that abdominal fat that won't shift.  The obesity rate is very high.

Added sugars drive nutrient and energy deficit in obesity: a new paradigm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975866/

Caffeine consumption can affect thiamine.  Caffeine makes thiamine not work.

And funky diets can be problematic...

"Restrictive diet in a patient with irritable bowel syndrome leading to Wernicke encephalopathy"

https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-021-01758-w

And....

Non-alcoholic Wernicke's encephalopathy: toxic ingestion or an honest mis-steak?

https://pubmed.ncbi.nlm.nih.gov/33552440/

And another....

Suspected dietary-related Wernicke's encephalopathy

https://pubmed.ncbi.nlm.nih.gov/31447924/

 

Keep in mind that most gluten containing products are fortified with thiamine mononitrate which is synthetic and doesn't mix with water, so it's not as bioactive as other forms of thiamine that do mix with water and fats.  

https://pediaa.com/difference-between-thiamine-mononitrate-and-thiamine-hydrochloride/

 

Prescription Medications:

These can cause thiamine deficiency.  Thiazide diuretics, metformin, and more can interfere with thiamine utilization in the body.

References in my "Thiamine, thiamine, thiamine" post.

 

SIBO:

SIBO microorganisms compete with your body for thiamine and other nutrients. 

Small Intestinal Bacterial Overgrowth

"SIBO causes vitamin deficiencies. Vitamin B12 deficiency occurs from ileal mucosal damage to cobalamin binding sites. Vitamin B1 and B3 deficiencies occur due to bacterial overutilization. In contrast, bacterial synthesis results in the elevation of folate and vitamin K levels."

https://www.ncbi.nlm.nih.gov/books/NBK546634/#!po=21.1538

And...

Heat and working outside in hot weather can affect thiamine status.  Global warming... scientists are noticing thiamine deficiency in fish, birds, plants, and animals in the wild.  

Emotional stress can also affect thiamine status.  Your brain consumes as much energy thinking as physical activity.  That's why a desk job can be as tiring as physical work.

So lots of different things can affect thiamine status.  Including other infections.

Viruses do like SIBO and steal nutrients from their hosts.  

"Severe Infections are Common in Thiamine Deficiency and May be Related to Cognitive Outcomes: A Cohort Study of 68 Patients With Wernicke-Korsakoff Syndrome"

https://pubmed.ncbi.nlm.nih.gov/27498674/

 

Association of Thiamine Intake with Human Papillomavirus (HPV) Infection in American Women: A Secondary Data Analysis Based on the National Health and Nutrition Examination Survey from 2003 to 2016

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670832/

 

Viruses can affect the thiamine transporter system inside the body.

Disruption of thiamine uptake and growth of cells by feline leukemia virus subgroup A

https://pubmed.ncbi.nlm.nih.gov/23269813/

Virtues can make the thiamine transporters shut down and not work.  This example is in cats, but there are other references in humans in my "Thiamine, thiamine, thiamine" post.  

Also in the same post are studies showing that the thiamine transporter gene which gets shut down by thiamine deficiency is located next to the Autoimmune Diseases section of the gene.  Once there's a thiamine deficiency and the transporters are turned off, the Autoimmune disease genes start turning on.  Depending on what is on your particular genes, autoimmune diseases start.  Celiac, diabetes, autoimmune thyroid disease, etc.

The good thing is that high dose Thiamine is able to saturate the body and get into cells without aid of transporters and turn the transporters back on.  Thiamine is essential to fighting viruses.  

Doctors are slowly learning this.

Encephalopathy responsive to thiamine in severe COVID-19 patients

https://pubmed.ncbi.nlm.nih.gov/33817670/

And...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011322/

 

Enhancing immunity in viral infections, with special emphasis on COVID-19: A review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161532/

 

Could Vitamins Help in the Fight Against COVID-19?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551685/

 

And...

Therapeutic Prospects for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-vitro Evidence and Pharmacokinetic Profile

https://pubmed.ncbi.nlm.nih.gov/32869036/

 

Repurposing Treatment of Wernicke-Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile.

https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/33737877

Or here..

https://www.frontiersin.org/articles/10.3389/fphar.2020.598128/full

 

I think that's all I have to say about that.

 

[knitty kitty]

Except cancer cells can turn off the body's thiamine transporters, too, like viruses.

B-cell lymphoma, thiamine deficiency, and lactic acidosis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242120/

 

Thiamine deficiency in patients with B-chronic lymphocytic leukaemia: a pilot study

 https://pmj.bmj.com/content/77/911/582

 

Linking vitamin B1 with cancer cell metabolism

https://cancerandmetabolism.biomedcentral.com/articles/10.1186/2049-3002-1-16

 

Think that'll do.

Edited July 28, 2021 by knitty kitty
Typo correction

[Posterboy]

To Whom Ever Might Read This,

I have had some health problems of late....but I wanted to provide a couple links for those who find this thread and have the time and interest to do the research on their on...

I listed most of the available resources in this Posterblog post that I have came across over the years.....

The extensive links/resources is in the appendix section at the end of the blog...

How Low B Vitamins can Trigger a Celiac disease diagnosis and be Mistaken for a Genetic Disease - Celiac.com

This one in particular explains how Zonulin levels have been tied to a  Niacin deficiency....

Zonulin...a marker for niacin issues? - Alobar Greywalker: Magickal Record (aka Frater PVN, LA-BAJ-AL) — LiveJournal

And while Zonulin is now associated with Celiac disease and or Leaky Gut issues......IT was once 30+ years ago know to be a sign of a Niacin deficiency....

Since these conditions only happened when the animal was low in Niacin......

A long forgotten association......I could say more....but these links/resources will give you all the information you need to research for  yourself and come to your own conclusion about the matter....

I have learned that doctors need to awaken to Vitamin deficiencies or serious medical conditions develop when they go undiagnosed or misdiagnosed in, and part of other diseases...

Serious Vitamin deficiencies are happening in Celiac disease and/or NCGS patients and they are going undiagnosed.....

It is not just me saying this.....the Mayo Clinic discovered the same thing a few  years ago...

Mayo Clinic Study Shows Micronutrient Deficiencies Are (Still) Common in Contemporary Celiac Disease Despite Lack of Overt Malabsorption Symptoms - Celiac.com

I have just tried to educate others of this overlooked medical fact....B-Vitamin deficiencies in Celiac are happening today and going UNdiagnosed!

I hope some of this is helpful but it is not medical advice....

2 Timothy 2:7  “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the grace of God,