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Serology Tests Post Covid Vaccination

plumbago

By plumbago
in Related Issues & Disorders

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plumbago Experienced
plumbago
Posted

Hello,

I received the last of my two-dose Moderna vaccine in January, and recently had my antibodies (to spike) tested, and they were very very high. I test a lot (antigen and occasional PCR) and have never tested positive. I'm curious to hear from others who may also have gone out and gotten an antibody test. What were your results? I'm posting this on the Celiac site mostly because I'm actually a bit concerned that they were so high. I understand that it's possible I was exposed and my immune system kicked in, but I am wearing PPE nearly always at work, so I'm kind of doubtful. Thanks!

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trents Grand Master
trents
Posted

What antibodies are you talking about as having spiked? Celiac antibodies or COVID? This is not clear to me from your post.

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RMJ Mentor
RMJ
Posted

I’d say high antibodies to the coronavirus spike protein is good!  One of the boosters being studied is supposed to increase them almost 10-fold, which is considered to be a good thing.

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plumbago Experienced
plumbago
  • Author
Posted
4 hours ago, trents said:

What antibodies are you talking about as having spiked? Celiac antibodies or COVID? This is not clear to me from your post.

Sorry. When I said  "spike" I meant antibodies to the spike protein.

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plumbago Experienced
plumbago
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Posted
2 hours ago, RMJ said:

I’d say high antibodies to the coronavirus spike protein is good!  One of the boosters being studied is supposed to increase them almost 10-fold, which is considered to be a good thing.

Thanks, RMJ, yes, you'd think so! But it's so many months afterwards, and if, as is commonly being said these days, antibodies wane, I have to ask myself almost in disbelief what my antibodies were 3,4,5 months ago, if, nearly 8 months later, they are on the super high end?! It's a bit concerning to me. Again, it could have been an exposure, though I am very careful and test frequently, and it could have been a lab error. It's all just a bit puzzling.

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Oldturdle Collaborator
Oldturdle
Posted

Congratulations on your high antibodies to the covid spike protein!  I am pretty sure this means you are very immune.  It may mean that you have been recently reinfected at the subclinical level, and were asymptomatic, but that means the vaccine worked.  Good for you for continuing to ware a mask.  You can't eat gluten with a mask on!

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plumbago Experienced
plumbago
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Posted
18 hours ago, Oldturdle said:

Congratulations on your high antibodies to the covid spike protein!  I am pretty sure this means you are very immune.  It may mean that you have been recently reinfected at the subclinical level, and were asymptomatic, but that means the vaccine worked.  Good for you for continuing to ware a mask.  You can't eat gluten with a mask on!

I have to wear a mask at work, but I do it other places as well (it's required indoors where I live, which is smart). As for getting infected (you said "re"infected), I tend not to think so because I am tested frequently. I will likely test the antibodies again, and if they're still high, I will think with greater certainty that it's the vaccine. But it just raises some questions for me.

And answers some too -- with antibodies that high, for me, there is no need for a booster. Indeed the healthcare agencies are starting to - at this date, Sept 4, 2021 - push back against boosters for the non-immunocompromised.

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RMJ Mentor
RMJ
Posted

I thought of something else - was the antibody test that you had designed to look for antibodies in people naturally infected, or people who were vaccinated?  That might make a difference in the range that is considered high.  The FDA authorized tests are intended to look for prior natural infection and are not recommended to look at vaccination status.

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plumbago Experienced
plumbago
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Posted
21 minutes ago, RMJ said:

I thought of something else - was the antibody test that you had designed to look for antibodies in people naturally infected, or people who were vaccinated?  That might make a difference in the range that is considered high.  The FDA authorized tests are intended to look for prior natural infection and are not recommended to look at vaccination status.

Yes, as mentioned, the test looked for antibodies to spike (ie, what the vaccination produces antibodies for), so it was just looking at that, and none of the other proteins. Thanks!

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