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Celiac.com Article:Anti-SARS-CoV-2 Immunoglobulin Profiles in Celiac Patients with COVID-19 Similar to Non-Celiacs

Jefferson Adams
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Jefferson Adams Grand Master
Jefferson Adams
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    • trents
      Celiac Test Results - Thoughts?

      By trents · Posted

      When you say a GI doc did an IGA five years ago and it was negative, which IGA measure do you speak of. There are several possibilities. Do you refer to the tTG-IGA? Have you had a total IGA test done? It isn't a test for celiac per se but can establish whether or not you are IGA deficient. If you are IGA deficient, it will drive individual IGA test scores down and can result in false positives. The tTG-IGA should always be accompanied by a total IGA test. When people are IGA deficient and actually do have celiac disease we often see it detected by the IGG tests. The same can be said if they have been skimping on gluten previous to the blood draw and, IMO, negatives in the IGA test spectrum with positives in the IGG spectrum can also point to NCGS or NCGS transitioning to celiac.
    • Scott Adams
      Celiac Test Results - Thoughts?

      By Scott Adams · Posted

      This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate. I agree that if your biopsy ends up negative, that you still may need to be gluten-free, as you could be in the non-celiac gluten sensitivity area. Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS. Be sure to eat lots of gluten daily until your endoscopy, otherwise you could get false negative results.    
    • hmkr
      Celiac Test Results - Thoughts?

      By hmkr · Posted

      I had several celiac blood tests done at a rheumatologist last month. I've had many possible symptoms over the last 23 years, including GERD/LPR, constipation, and recently joint stiffness and pain in my hands. It all started during my first pregnancy. 1/160 ANA back then as well as now with no autoimmune diagnosis. I've had undiagnosed high fevers, swollen lymphs nodes, ear pain, miscarriages, to name just a few more symptoms. I can't help but be upset at the many doctors I've been to that have missed this. A GI doctor only did the IgA 5 years ago, which was negative then too, and didn't do a biopsy as a result during an endoscopy shortly after. Deaminated Gliadin IgG Antibody test was 90, >15 being abnormal.   Deaminated Gliadin IgA Antibody, negative Tissue Transglutaminase IgG Antibody, negative Tissue Transglutaminase IgA Antibody, negative I'm scheduled for a biopsy at the end of January. The new GI doctor thinks if not celiac, I will still need to be gluten free the rest of my life due to the antibodies my body is producing. I feel like it's got to be celiac. I've been consuming gluten every day to prepare for this test. It can't come soon enough.  Thoughts on that IgG being positive and the others negative? I haven't gotten a clear explanation for that yet. Thanks in advance for any input!! 
    • Kiwifruit
      Years of testing - no real answers

      By Kiwifruit · Posted

      That’s good to know. Might be time to head back to my gastrointestinal doctor then.
    • trents
      Years of testing - no real answers

      By trents · Posted

      Yeah, you may not have been consuming enough gluten to result in valid testing.
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