Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

tTg-IgA and DGP-IgG negative, is it worth waiting for anti-Gliadin IgA/IgG?

Ippodrom234
 Share

Recommended Posts

Ippodrom234 Newbie
Ippodrom234
Posted

Hi! Male, 31.

Health issues: constipation, sluggish digestion in general, greasy stools, bloating, fatigue, brain fog, dry skin. Low thyroid hormones free t3/T4 with normal TSH.

I've seen numerous Drs, none has ordered a celiac test panel, so decided to test one myself. Have been on a heavy gluten diet for at least 4 months. 

The results so far are all normal and not suggestive of Celiac disease in the slightest:

Total IgA - 1.79 (range 0.63 — 4.84)

tTg-IgA <1.00 (range <10.00)

DGP-IgG 1.2 (range <10.0).

I also had blood drawn for anti-Gliadin IgA/IgG (not deamidated this time), the results should be available tomorrow.

I know the latter are old tests and now considered unreliable but I want to make sure I don't have Celiac and If I do - well, that would at least explain many of the symptoms. I want to see if I have autoimmunity, not NSGS.

All in all, do you think that with the results I have after eating lots of gluten for several months I can consider myself non-Celiac? Of course, I will consult a doctor if needed, but they seem to be more concerned with treating symptoms, not the cause.

Thanks!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


trents Grand Master
trents
Posted

Sounds like you may not have celiac disease since the antibody tests so far don't indicate villi damage in the small bowel. But I would look at NCGS (Non Celiac Gluten Sensitivity) if I were you. The antidote is the same. Total abstinence from gluten for life. The next step would be to commit to a gluten free diet and see if your symptoms improve.

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. trents
      - trents replied to LizzieF's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Testing Help

      @LizzieF, if you will be seeking repeat blood antibody testing after undergoing a more rigorous gluten challenge, make sure your physician orders the "total IGA" test to check for IGA deficiency. If you are IGA deficient, all other IGA test scores will be artificially low and this can result in false negatives. Can you list the blood antibody tests that...
    2. knitty kitty
      - knitty kitty replied to LizzieF's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Testing Help

      @LizzieF, The anemia which can be caused by low iron can impede antibody production. NCGS can be a precursor of Celiac Disease, especially in those who already carry Celiac genes. Celiac is the only disease where you have to self harm to get a diagnosis. Do talk to your doctor about the updated gluten challenge requirements and a...
    3. trents
      - trents replied to LizzieF's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Testing Help

      Welcome to the forum, @LizzieF! Yes, I also question whether or not your exposure to gluten before either the endoscopy/biopsy or the antibody testing was long enough or intense enough to render valid test results. Guidelines for the "gluten challenge" have recently been revised to recommend more intense exposure: at least 10g of gluten (about the amount...
    4. trents
      - trents replied to ChrisDun's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      2

      Intermittent Fatigue

      Chris, has your husband had a recent checkup with detailed bloodwork (CBC and CMP)? Has he been checked for vitamin and mineral deficiencies?
    5. LizzieF
      - LizzieF posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Testing Help

      Hi everyone - I have been gluten free for 2+ years after doing some genetic testing that showed inability to process gluten and carrying a gene for celiac (I’ve had GI related issues for 20+ years that were diagnosed as IBS/lactose intolerance). After persistent low iron, new GI suggested we look at celiac. Endoscopy results noted the below. I have to add t...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      129,177
    • Most Online (within 30 mins)
      7,748
    Whov19
    Newest Member
    Whov19
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.2k
    • Total Posts
      71.5k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • trents
      Testing Help

      By trents · Posted

      @LizzieF, if you will be seeking repeat blood antibody testing after undergoing a more rigorous gluten challenge, make sure your physician orders the "total IGA" test to check for IGA deficiency. If you are IGA deficient, all other IGA test scores will be artificially low and this can result in false negatives. Can you list the blood antibody tests that were already done, the scores along with the reference ranges?
    • knitty kitty
      Testing Help

      By knitty kitty · Posted

      @LizzieF, The anemia which can be caused by low iron can impede antibody production.   NCGS can be a precursor of Celiac Disease, especially in those who already carry Celiac genes.   Celiac is the only disease where you have to self harm to get a diagnosis.   Do talk to your doctor about the updated gluten challenge requirements and a repeat endoscopy.
    • trents
      Testing Help

      By trents · Posted

      Welcome to the forum, @LizzieF! Yes, I also question whether or not your exposure to gluten before either the endoscopy/biopsy or the antibody testing was long enough or intense enough to render valid test results. Guidelines for the "gluten challenge" have recently been revised to recommend more intense exposure: at least 10g of gluten (about the amount in 4-6 slices of wheat bread) daily for at least two weeks leading up to the day of the blood draw or the procedure. But frankly, I would certainly give it twice that long to be sure. It is also very possible you are dealing with NCGS (Non Celiac Gluten Sensitivity) instead of celiac disease. They share many of the same symptoms but NCGS does not damage the villous lining of the small bowel. Therefore, not antibodies are produced and nothing will show up on a biopsy either. There is no test for NCGS and it is 10x more common than celiac disease. Some experts believe NCGS can be a precursor to celiac disease. Celiac diseases must first be ruled out to arrive at a dx of NCGS.
    • trents
      Intermittent Fatigue

      By trents · Posted

      Chris, has your husband had a recent checkup with detailed bloodwork (CBC and CMP)? Has he been checked for vitamin and mineral deficiencies?
    • LizzieF
      Testing Help

      By LizzieF · Posted

      Hi everyone - I have been gluten free for 2+ years after doing some genetic testing that showed inability to process gluten and carrying a gene for celiac (I’ve had GI related issues for 20+ years that were diagnosed as IBS/lactose intolerance). After persistent low iron, new GI suggested we look at celiac. Endoscopy results noted the below. I have to add that I added gluten for about 12 days prior to my test (and was miserable in the process). “The differential diagnosis includes celiac disease, but the degree of intraepithelial lymphocytes does not reach the threshold for Marsh 1 lesion.” Chrons/Colitis negative. GI suggested I continue eating gluten (after a 3 day pause awaiting results) to do bloodwork. I ate gluten for another 1.5 weeks (about 4 weeks in total) and blood work came back normal. My symptoms however have continued to get worse with changes in bowl habits, sharp pains in the abdomen and nausea.  I feel like I did not have gluten for enough time prior to my endoscopy for accurate results. What do you do in such a case? (Note: still pending follow up from GI)
×
×
  • Create New...