Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

what is all about ?

grumbleguts
 Share

Recommended Posts

grumbleguts Rookie
grumbleguts
Posted
  • Author
12 hours ago, knitty kitty said:

@grumbleguts,

Be aware that Metformin will cause B12, folate, and thiamine deficiency.  

I suggest you discuss with your doctor supplementing thiamine as well as B12 and folate.

B12 and thiamine deficiencies can cause symptoms of altered mentation before blood tests reveal deficiency.  

Diabetics, both type one and two, have been shown to have low thiamine levels.  Adding Metformin can cause outright thiamine deficiency.

Gestational diabetes is shown to be connected to low thiamine levels. 

Gastroparesis, slow emptying of the stomach, is another symptom of low thiamine levels.  Gastritis is also seen with insufficient Thiamine levels. 

Thiamine deficiency can have symptoms of altered mental status called Wernicke's Encephalopathy.  

Do you feel your mentality has changed in the time you've been taking Metformin? Having memory difficulty?  Fatigue? 

Since blood tests aren't an accurate measurement of thiamine stores, high dose Thiamine supplementation (>500 mg/day) for several days should produce improvement in symptoms.

The World Health Organization -WHO - says a thiamine deficiency can be diagnosed if supplementing with 500 mg thiamine hydrochloride brings improvement.  Some get improvement within hours.  

I took Metformin and got very ill and the doctors were clueless as to the interconnection between Celiac, Diabetes (yes, @trents, there is a connection with type two diabetes and Celiac*), and thiamine deficiency.

Do discuss thiamine deficiency with your doctor!

*  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639597/

 

I will. certainly check up thiamin info with her... 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


plumbago Experienced
plumbago
Posted

I would advise you checking with your doctor to see if you can get B vitamin levels checked. Just because metformin - a highly useful drug - can cause B vitamin deficiency doesn't mean it will or does in you specific case. If you have celiac disease, you may have malabsorption of those vitamins because of it.

Also, as you know as someone with type 2 diabetes, gastroparesis could occur due to some nerve impairment of the vagus nerve which facilitates digestion.

Plumbago

grumbleguts Rookie
grumbleguts
Posted
  • Author
3 hours ago, plumbago said:

I would advise you checking with your doctor to see if you can get B vitamin levels checked. Just because metformin - a highly useful drug - can cause B vitamin deficiency doesn't mean it will or does in you specific case. If you have celiac disease, you may have malabsorption of those vitamins because of it.

Also, as you know as someone with type 2 diabetes, gastroparesis could occur due to some nerve impairment of the vagus nerve which facilitates digestion.

Plumbago

Thank you. I will indeed have a word with my doc. nobody has ever spoken to me aboutthis before. the slow transit has been will me all my life since birth.  Lovely flower by the way. 

CJolly Newbie
CJolly
Posted
On 3/16/2022 at 10:16 AM, trents said:

I don't think that is the mechanism involved in generating celiac disease. It's not the slow transit that is the issue. It is the immune system misinterpreting gluten as an invader. See my previous post above. So, the real problem is that something in the immune system is haywire that causes it to mistakenly identify gluten as harmful.

By the way, the biopsies of your stomach may have been triggered by your anemia. There is a kind of anemia known as "pernicious anemia." With pernicious anemia, there is an autoimmune attack of the parietal cells that line the stomach. The parietal cells produce an enzyme know as "intrinsic factor" which is necessary for the absorption of B12, which in turn is necessary for the absorption of iron from our diet. And so, the result is iron deficiency anemia. One way to compensate for that is B12 injections. We have also discovered that large doses of B12 orally can also work as there is a secondary, less efficient pathway for B12 absorption by the body.

I have a very high WBC, over 13K for over a year now, with the symptoms of low Vit. D, B12, and weight loss, diarrhea etc... I am curious if others with celiac also have high WBC because of the inflammation. Thanks so much!

knitty kitty Grand Master
knitty kitty
Posted
4 hours ago, grumbleguts said:

Sorry to bother you again but would a problem with three different types of benign tumours i have had also be caused by a sightly deranged auto immune system? . No one else in my immediate family of parents and 8 siblings have ever had the health problems i have had?

I found this article....

Celiac Disease Associated with a Benign Granulomatous Mass Demonstrating Self-Regression after Initiation of a Gluten-Free Diet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624261/

"...celiac disease can also be associated with benign small bowel thickening and reactive lymphadenopathy. These reactive changes do not always represent malignancy and often regress after the institution of a gluten-free diet (GFD) as the inciting antigen is removed."

 

trents Grand Master
trents
Posted
(edited)
1 hour ago, CJolly said:

I have a very high WBC, over 13K for over a year now, with the symptoms of low Vit. D, B12, and weight loss, diarrhea etc... I am curious if others with celiac also have high WBC because of the inflammation. Thanks so much!

That I am aware of, high WBC is not a typical symptom associated with celiac disease. But your other symptoms are classic for either celiac disease or NCGS (Non Celiac Gluten Sensitivity) which is 10x more common than celiac disease. There is no diagnostic test for NCGS. celiac disease must first be ruled out. Sounds like you need to be tested for celiac disease.

Edited by trents
grumbleguts Rookie
grumbleguts
Posted
  • Author
1 hour ago, knitty kitty said:

I found this article....

Celiac Disease Associated with a Benign Granulomatous Mass Demonstrating Self-Regression after Initiation of a Gluten-Free Diet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624261/

"...celiac disease can also be associated with benign small bowel thickening and reactive lymphadenopathy. These reactive changes do not always represent malignancy and often regress after the institution of a gluten-free diet (GFD) as the inciting antigen is removed."

 

One was in My stomach, one in womb and bilateral in latisimus dorssi. all having been exised. So  not applicable... really. Thank you.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


CJolly Newbie
CJolly
Posted
7 hours ago, trents said:

That I am aware of, high WBC is not a typical symptom associated with celiac disease. But your other symptoms are classic for either celiac disease or NCGS (Non Celiac Gluten Sensitivity) which is 10x more common than celiac disease. There is no diagnostic test for NCGS. celiac disease must first be ruled out. Sounds like you need to be tested for celiac disease.

Thanks so much. This is all new to me. Such great knowledge on this website. 

plumbago Experienced
plumbago
Posted
8 hours ago, CJolly said:

I have a very high WBC, over 13K for over a year now, with the symptoms of low Vit. D, B12, and weight loss, diarrhea etc... I am curious if others with celiac also have high WBC because of the inflammation. Thanks so much!

Hi,

I have not had high WBC on a routine blood test. Not to say I never ever have had elevated WBCs, but during my celiac disease testing phase, my WBC were never elevated. What was elevated, was what was found on endoscopy: intra-epithelial lymphocytes (IELS), in my small intestines.

Of course, I've had low D - something that is practically epidemic in the modern world, regardless of Celiac status and B12, and yes, the diarrhea.

Plumbago

Wheatwacked Veteran
Wheatwacked
Posted

though the Power of the Internet:

300 Signs and Symptoms of Celiac Disease (adults and children)

Here is a list of some essential vitamins and minerals. image.png.01574952b901095b13a2b2e3577dc2f7.pngVitaminRDA

Wheatwacked Veteran
Wheatwacked
Posted
On 3/17/2022 at 8:40 AM, grumbleguts said:

I had a tumour that resulted in a partial gastrectomy

If you've had a partial gastrectomy, you may be able to get enough vitamins and minerals from your diet by eating foods that are high in nutrients – in particular, foods high in iron, calcium, and vitamins C and D.     https://www.nhs.uk/conditions/gastrectomy/recovery/

Funny that article by the NHS does not mention B12.  I understand the no oral B12 is because the gastrectomy reduces absorbtion and injection guarantees that you get enough. But what of the others? Vitamin C, Zinc and others are essential to fighting infection.

Many of the deficiencies from celiac disease intersect with gastrectomy. Which came first? Does not matter at this point.

Post-Gastrectomy: Managing  the Nutrition Fall-Out

 

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      127,878
    • Most Online (within 30 mins)
      7,748
    Dcecilio
    Newest Member
    Dcecilio
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.5k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Scott Adams
      Hidden Gluten in distilled vinegar

      By Scott Adams · Posted

      @Mynx, how long have you been gluten-free? I ask because many newly diagnosed celiacs react to many things, and often think their reactions are caused by gluten, when in fact, they are really caused by a combination of a sensitive gut due to damage, as well as additional food intolerance/leaky gut issues to other foods which may be temporary until their villi heal.
    • Scott Adams
      Hidden Gluten in distilled vinegar

      By Scott Adams · Posted

      Many major brands of distilled vinegar in the USA, including Heinz white vinegar, are typically made from corn. In the United States, corn is a common and cost-effective raw material used in the production of distilled white vinegar. The process involves fermenting the sugars derived from corn into alcohol, which is then further fermented into acetic acid to produce vinegar. Distillation follows, which purifies the liquid and removes impurities, including any residual proteins or allergens. While the source of the vinegar (e.g., corn) is not always explicitly stated on the label, corn-derived vinegar is widely used in the food industry due to its neutral flavor and affordability. For individuals with gluten intolerance or celiac disease, distilled vinegar made from corn is generally considered safe, as the distillation process effectively removes gluten proteins. However, if you have concerns about cross-contamination or specific sensitivities, it’s always a good idea to contact the manufacturer directly to confirm the sourcing and production practices. Heinz, for example, has stated that their distilled white vinegar is gluten-free and safe for those with celiac disease, but verifying this information can provide additional peace of mind. The belief that distilled vinegar is gluten-free is rooted in the scientific understanding that gluten proteins, which are large and complex molecules, are generally too big to pass through the distillation process. Distillation involves heating a liquid to create vapor, which is then condensed back into a liquid form, leaving behind larger molecules like gluten proteins. However, the concern about cross-contamination arises from the possibility that gluten-containing ingredients may have been present in the liquid prior to distillation. While the distillation process itself is highly effective at removing gluten, the equipment used in production could potentially introduce trace amounts of gluten if not thoroughly cleaned between batches. For most individuals with gluten sensitivity or celiac disease, distilled vinegar is considered safe because the gluten content, if any, is typically below the threshold that would trigger a reaction. However, for those with extreme gluten intolerance or celiac disease, even trace amounts can cause adverse effects. This is why some individuals, like yourself, may choose to avoid commercially produced distilled vinegar and opt for alternatives like apple cider vinegar, which can be verified as gluten-free. The meticulous process of researching ingredients and preparing homemade products, such as ketchup, is indeed challenging but crucial for maintaining health and avoiding gluten exposure. It’s important to note that regulatory standards for gluten-free labeling vary by region, and in many places, products labeled "gluten-free" must contain less than 20 parts per million (ppm) of gluten, which is considered safe for the vast majority of people with celiac disease. Nonetheless, individual sensitivity levels can vary, and your approach highlights the importance of personalized dietary management for those with severe gluten intolerance.
    • Bebee
      Testing for celiac

      By Bebee · Posted

      I have been diagnosed with Microscopic Colitis (LC) for quite a few years, so I have been gluten-free and DF.  I would like to get tested for Celiac Disease because of the possibility of cross contamination and colon cancer.  And if you were hospitalized and didn't have a celiac diagnosis you could not get gluten-free food, I don't know if that is true or not.  Also because there is chance of colon cancer so I want to know if I have Celiac Disease and need to be on very restrictive diet.  The only testing I did was a sigmoid scope and Enter Lab but no gene testing.  I know I can go back to eating gluten for a few months, but I would worry you would have to stay home for the few months while getting gluten.  What other options do I have?  Should I do the gene testing?  Maybe through Entero Lab?  Any other tests?  How important is it to have Celiac diagnosed? Thank you! Barb
    • trents
      Hidden Gluten in distilled vinegar

      By trents · Posted

      Take it easy! I was just prompting you for some clarification.  In the distillation process, the liquid is boiled and the vapor descends up a tube and condenses into another container as it cools. What people are saying is that the gluten molecules are too large and heavy to travel up with the vapor and so get left behind in the original liquid solution. Therefore, the condensate should be free of gluten, no matter if there was gluten in the original solution. The explanation contained in the second sentence I quoted from your post would not seem to square with the physics of the distillation process. Unless, that is, I misunderstood what you were trying to explain.
    • Mynx
      Hidden Gluten in distilled vinegar

      By Mynx · Posted

      No they do not contradict each other. Just like frying oil can be cross contaminated even though the oil doesn't contain the luten protein. The same is the same for a distilled vinegar or spirit which originally came from a gluten source. Just because you don't understand, doesn't mean you can tell me that my sentences contradict each other. Do you have a PhD in biochemistry or friends that do and access to a lab?  If not, saying you don't understand is one thing anything else can be dangerous to others. 
×
×
  • Create New...