Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

what is all about ?

grumbleguts
 Share

Recommended Posts

grumbleguts Rookie
grumbleguts
Posted
  • Author
12 hours ago, knitty kitty said:

@grumbleguts,

Be aware that Metformin will cause B12, folate, and thiamine deficiency.  

I suggest you discuss with your doctor supplementing thiamine as well as B12 and folate.

B12 and thiamine deficiencies can cause symptoms of altered mentation before blood tests reveal deficiency.  

Diabetics, both type one and two, have been shown to have low thiamine levels.  Adding Metformin can cause outright thiamine deficiency.

Gestational diabetes is shown to be connected to low thiamine levels. 

Gastroparesis, slow emptying of the stomach, is another symptom of low thiamine levels.  Gastritis is also seen with insufficient Thiamine levels. 

Thiamine deficiency can have symptoms of altered mental status called Wernicke's Encephalopathy.  

Do you feel your mentality has changed in the time you've been taking Metformin? Having memory difficulty?  Fatigue? 

Since blood tests aren't an accurate measurement of thiamine stores, high dose Thiamine supplementation (>500 mg/day) for several days should produce improvement in symptoms.

The World Health Organization -WHO - says a thiamine deficiency can be diagnosed if supplementing with 500 mg thiamine hydrochloride brings improvement.  Some get improvement within hours.  

I took Metformin and got very ill and the doctors were clueless as to the interconnection between Celiac, Diabetes (yes, @trents, there is a connection with type two diabetes and Celiac*), and thiamine deficiency.

Do discuss thiamine deficiency with your doctor!

*  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639597/

 

I will. certainly check up thiamin info with her... 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


plumbago Experienced
plumbago
Posted

I would advise you checking with your doctor to see if you can get B vitamin levels checked. Just because metformin - a highly useful drug - can cause B vitamin deficiency doesn't mean it will or does in you specific case. If you have celiac disease, you may have malabsorption of those vitamins because of it.

Also, as you know as someone with type 2 diabetes, gastroparesis could occur due to some nerve impairment of the vagus nerve which facilitates digestion.

Plumbago

grumbleguts Rookie
grumbleguts
Posted
  • Author
3 hours ago, plumbago said:

I would advise you checking with your doctor to see if you can get B vitamin levels checked. Just because metformin - a highly useful drug - can cause B vitamin deficiency doesn't mean it will or does in you specific case. If you have celiac disease, you may have malabsorption of those vitamins because of it.

Also, as you know as someone with type 2 diabetes, gastroparesis could occur due to some nerve impairment of the vagus nerve which facilitates digestion.

Plumbago

Thank you. I will indeed have a word with my doc. nobody has ever spoken to me aboutthis before. the slow transit has been will me all my life since birth.  Lovely flower by the way. 

CJolly Newbie
CJolly
Posted
On 3/16/2022 at 10:16 AM, trents said:

I don't think that is the mechanism involved in generating celiac disease. It's not the slow transit that is the issue. It is the immune system misinterpreting gluten as an invader. See my previous post above. So, the real problem is that something in the immune system is haywire that causes it to mistakenly identify gluten as harmful.

By the way, the biopsies of your stomach may have been triggered by your anemia. There is a kind of anemia known as "pernicious anemia." With pernicious anemia, there is an autoimmune attack of the parietal cells that line the stomach. The parietal cells produce an enzyme know as "intrinsic factor" which is necessary for the absorption of B12, which in turn is necessary for the absorption of iron from our diet. And so, the result is iron deficiency anemia. One way to compensate for that is B12 injections. We have also discovered that large doses of B12 orally can also work as there is a secondary, less efficient pathway for B12 absorption by the body.

I have a very high WBC, over 13K for over a year now, with the symptoms of low Vit. D, B12, and weight loss, diarrhea etc... I am curious if others with celiac also have high WBC because of the inflammation. Thanks so much!

knitty kitty Grand Master
knitty kitty
Posted
4 hours ago, grumbleguts said:

Sorry to bother you again but would a problem with three different types of benign tumours i have had also be caused by a sightly deranged auto immune system? . No one else in my immediate family of parents and 8 siblings have ever had the health problems i have had?

I found this article....

Celiac Disease Associated with a Benign Granulomatous Mass Demonstrating Self-Regression after Initiation of a Gluten-Free Diet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624261/

"...celiac disease can also be associated with benign small bowel thickening and reactive lymphadenopathy. These reactive changes do not always represent malignancy and often regress after the institution of a gluten-free diet (GFD) as the inciting antigen is removed."

 

trents Grand Master
trents
Posted
(edited)
1 hour ago, CJolly said:

I have a very high WBC, over 13K for over a year now, with the symptoms of low Vit. D, B12, and weight loss, diarrhea etc... I am curious if others with celiac also have high WBC because of the inflammation. Thanks so much!

That I am aware of, high WBC is not a typical symptom associated with celiac disease. But your other symptoms are classic for either celiac disease or NCGS (Non Celiac Gluten Sensitivity) which is 10x more common than celiac disease. There is no diagnostic test for NCGS. celiac disease must first be ruled out. Sounds like you need to be tested for celiac disease.

Edited by trents
grumbleguts Rookie
grumbleguts
Posted
  • Author
1 hour ago, knitty kitty said:

I found this article....

Celiac Disease Associated with a Benign Granulomatous Mass Demonstrating Self-Regression after Initiation of a Gluten-Free Diet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624261/

"...celiac disease can also be associated with benign small bowel thickening and reactive lymphadenopathy. These reactive changes do not always represent malignancy and often regress after the institution of a gluten-free diet (GFD) as the inciting antigen is removed."

 

One was in My stomach, one in womb and bilateral in latisimus dorssi. all having been exised. So  not applicable... really. Thank you.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


CJolly Newbie
CJolly
Posted
7 hours ago, trents said:

That I am aware of, high WBC is not a typical symptom associated with celiac disease. But your other symptoms are classic for either celiac disease or NCGS (Non Celiac Gluten Sensitivity) which is 10x more common than celiac disease. There is no diagnostic test for NCGS. celiac disease must first be ruled out. Sounds like you need to be tested for celiac disease.

Thanks so much. This is all new to me. Such great knowledge on this website. 

plumbago Experienced
plumbago
Posted
8 hours ago, CJolly said:

I have a very high WBC, over 13K for over a year now, with the symptoms of low Vit. D, B12, and weight loss, diarrhea etc... I am curious if others with celiac also have high WBC because of the inflammation. Thanks so much!

Hi,

I have not had high WBC on a routine blood test. Not to say I never ever have had elevated WBCs, but during my celiac disease testing phase, my WBC were never elevated. What was elevated, was what was found on endoscopy: intra-epithelial lymphocytes (IELS), in my small intestines.

Of course, I've had low D - something that is practically epidemic in the modern world, regardless of Celiac status and B12, and yes, the diarrhea.

Plumbago

Wheatwacked Veteran
Wheatwacked
Posted

though the Power of the Internet:

300 Signs and Symptoms of Celiac Disease (adults and children)

Here is a list of some essential vitamins and minerals. image.png.01574952b901095b13a2b2e3577dc2f7.pngVitaminRDA

Wheatwacked Veteran
Wheatwacked
Posted
On 3/17/2022 at 8:40 AM, grumbleguts said:

I had a tumour that resulted in a partial gastrectomy

If you've had a partial gastrectomy, you may be able to get enough vitamins and minerals from your diet by eating foods that are high in nutrients – in particular, foods high in iron, calcium, and vitamins C and D.     https://www.nhs.uk/conditions/gastrectomy/recovery/

Funny that article by the NHS does not mention B12.  I understand the no oral B12 is because the gastrectomy reduces absorbtion and injection guarantees that you get enough. But what of the others? Vitamin C, Zinc and others are essential to fighting infection.

Many of the deficiencies from celiac disease intersect with gastrectomy. Which came first? Does not matter at this point.

Post-Gastrectomy: Managing  the Nutrition Fall-Out

 

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      126,204
    • Most Online (within 30 mins)
      7,748
    DreDre
    Newest Member
    DreDre
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.2k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • kopiq
      starting to heal, vitamin d deficiant but cannot tolerate vitamins. what to do? also multiple ongoing issues.

      By kopiq · Posted

      I also have food particles left on toiet paper when i wipe and my stool is light yellow not absorbing fats. I urinate about 15 times a day and have very sticky snot,dry throat.
    • kopiq
      starting to heal, vitamin d deficiant but cannot tolerate vitamins. what to do? also multiple ongoing issues.

      By kopiq · Posted

      Hi all, I was diagnosed by blood work about 2 months ago and have since went on a strict gluten free diet. I have an endoscopy in January and the GI dr said nothing about staying on gluten for it; hes aware i went no gluten. starting to heal symptoms include: (this is huge) sensation coming back to genitals and when having a bowl movement. everything has been numb for a long time down there including lower belly button area. good size (not abnormal) bowel movements once a day or every two days. small dot size wart just fell off my finger that was there for years. have not broke out with a cold sore this winter (every winter prior for years i would develop a cold sore on my lip) Ongoing issues I don't sweat. not from my hands, or armpits or feet. I do not get butterflys in stomach. my hands have been so dry for years ive been using a crack cream as they crack and bleed very severely in the fall and winter.  (since going gluten free ive not used crack cream but they are still very very dry and chapped/flaky, no sweat or moisture in palms of hands at all. I dont crave food. i have no cravings at all, not for pizza, ice cream , nothing. my cravings are dead. smell of foods kinda make me hungry, but my stomach blocks it. pins needles in feet get weak legs standing up from sitting and dizzy, things almost turn black. i cannot tolerate veggies or vitamins. Iam vitamin D deficient according to my Dr and Ive tried vitamin D pills. they give me a massive migraine for 8 hours and upset my stomach. the heat from the direct sun make me extremely tired to the point of wanting to pass out. again i don't sweat. broccoli gives me a migraine headache as well. mushrooms, bell peppers burn my stomach. fruits burn my stomach, fats (peanut butter, any oil or fat from meats make me sick to my stomach for a couple hours or longer. salt and pepper burns my stomach. all these issues cause pain at my belly button area and expand to the rest of my upper stomach and sides the more i ingest through out the day. I currently eat bland basmati rice, chicken, pork chops (fat trim), boiled russet potatoes no skin for three meals a day. my snacks are gluten free ground buckwheat flour pancakes. (just water, no oil , salt, dairy.) how am i to get vitamins in my system if i cannot tolerate them in my stomach? i mentioned epidermal vitamin patchs but dr said no. why cant i stand the heat from the sun ? why cant i sweat? thanks for any info.                
    • trents
      Celiac Maybe a Possibility?

      By trents · Posted

      Because you have significantly reduced your gluten intake over a considerable amount of time, it is likely that you will test negative on the antibody tests. However, if the $112 for the Quest test is not a burden, it wouldn't hurt to try. It tests for total IGA (to ascertain if you are IGA deficient) and tTG-IGA. If total IGA is deficient, it can result in false negatives in other IGA tests. The tTG-IGA is the single most popular test ordered by physicians. The Quest test is not a complete celiac panel by any means (refer to the linked article above) but it might be a good place to start. Personally, I think you know enough to conclude that you need to get serious about avoiding gluten, whether you have celiac disease or NCGS. Human nature being what it is, however, many people seem to need an official diagnosis of celiac disease in order to stay on the bandwagon. Otherwise, they seem to rationalize cheating on the gluten-free diet. And there is this misconception out there that NCGS is inconvenient and uncomfortable but not harmful so it's okay to cheat. The more we learn about gluten-related disorders the more they seem to not fit into our neat little black and white categories. By the way, celiac disease is not a food allergy. It is classified as an autoimmune disorder.
    • More2Learn
      Celiac Maybe a Possibility?

      By More2Learn · Posted

      These responses are all extremely helpful, ty.  Really good reminder about omega 6.  I also know I'm low in zinc; I took the zinc test where I drank it on a spoon and couldn't taste it.  To that end, I try to eat a lot of oysters.  I do think it would be a good idea to get the blood test.  Two questions: 1-  Is there any reason you wouldn't recommend that I just buy and take a test like this as a first step? 2- I've been somewhat gluten free since ~Jan 2023 (technically organic, gluten free, soy free, light on dairy).  I eat a lot of meat, vegetables, rice -- a common breakfast for me is three eggs and a sausage link, and I can't remember the last time I had a sandwich or bread.  However, because in my mind I didn't think I had an allergy, and I more was doing gluten free to avoid artificially iron-enriched foods, I do make exceptions.  I'll eat breaded calamari.  When my Dad visits, I split mozzarella sticks with him because he loves them so much.  I'll eat the "gluten sensitive" items at a restaurant and if they asked, "is cross contamination ok?",  I always said yes.  Based on that, since I never probably fully eliminated gluten, but it was significantly reduced... is that good enough to take the blood test?  Because the pain in my side gets SO bad (really sometimes I can't function, and I absolutely thought I was dying), I am hesitant to do the gluten challenge.  Would it make sense to take the test, and if it's negative, then consider doing the challenge and seeing if I can deal with eating the bread every day? Thanks again!
    • Yaya
      Muscle Twitching

      By Yaya · Posted

      For me, with osteoporosis, Celiac and more than 1 heart condition, the slower, safer route is preferable.  I'm on 5 meds per day.  Too much of anything can disturb absorption of this or that. Have a Happy Thanksgiving.  I'm gone for a few days.  
×
×
  • Create New...