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Positive anti-gliadin on gluten-free diet: cross-reactivity??

Lady Rose
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Lady Rose Newbie
Lady Rose
Posted

Hi there!

I have been gluten-free for most of my life and am extremely careful about contamination. I have a completely gluten-free household including all of my cleaning products, hygiene and beauty products, and even art supplies.

Lately I've been having a nasty autoimmune flare, so I went in for testing. My test results were mostly normal except for two things: SIBO and anti-gliadin IgA. 

I've retraced my every move looking for gluten contamination and can't find any culprits. Does anyone know if cross-reactivity can elevate anti-gliadin IgA levels? Any research or materials you can point me to would be much appreciated!

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Wheatwacked Veteran
Wheatwacked
Posted
3 hours ago, Lady Rose said:

normal except for two things: SIBO and anti-gliadin IgA

"Antigliadin antibodies (AGAs) are antibodies of the IgA and IgG classes found in the serum of celiac disease patients. These antibodies mainly target gliadin-derived peptides, which are the main proteins of gluten. AGAs are not specific for celiac disease as they are also found in patients with other gastrointestinal diseases such as gastritis, gastroenteritis, and IBD."   https://healthmatters.io/understand-blood-test-results/anti-gliadin-iga

SIBO can be What to know about SIBO and its treatment

Low stomach acid from PPI's, not enough fiber to feed the good bacteria, antibiotics kill the good along with the bad bacteria.  Other medications can disrupt the gut. Vitamin and mineral deficiencies. In particular the fortified vitamins in wheat products (E, folic acid, iron) that you are not eating. Most Americans don't eat enough choline and potassium. One study found over 60% of the women of child bearing age they tested were low in iodine. Low Vitamin D is common with autoimmune disease.

Scott Adams Grand Master
Scott Adams
Posted

This research indicates that in some people cow's milk intolerance can elevate tTG levels:

 

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