GliadinX available

[PME]

16 hours ago, docaz said:

The most common situation is when shared utensils are not adequately cleaned and in that case one capsule is enough.

If you find out that you have accidentally eaten gluten after the fact then please take GliadinX as soon as possibly and preferably within 30-90 minutes while the food bolus is still in the stomach. In vivo and in vitro studies have shown that GliadinX can break down about 1/8 to 1/3 slices of bread. (A researcher at the University of Chicago says 1/8 and the Dutch team who worked on the product determined that it is about 1/3 slice.) I have purposely maximized the concentration even if it is a little more expensive and also adjusted the acidity to further boost the effect to allow also for accidental consumption of gluten. We all know that it just happens but I emphasize here accidental and not intentional. This is not a hint or encouragement to eat gluten but it means exactly what it says.

Please use the chart on this page to determine the amount of capsules https://www.gliadinx.com/instructions

Beyond that time frame, GliadinX will not help anymore because it is only effective in the stomach together with the naturally occurring stomach enzymes.

Thank you! So very helpful! 

[Scott Adams]

In summary, AN-PEP has been shown in published scientific studies to break down anywhere between 1/8 to 1/3 of a slice of wheat bread! If that is not the most amazing development that has come along in the treatment of celiac disease and/or gluten sensitivity in the past 25 years, what is? How much cross contamination would you likely get in a restaurant where you might order off a gluten-free menu, or order items you know are naturally gluten-free? What if they cooked your eggs and hash browns on an area where they cooked pancakes, or they cooked a lettuce-wrapped burger on a grill where they toasted wheat buns? What if they pulled the croutons out of a salad they gave you? How much gluten would this be?

Again, I am not encouraging anyone to be unsafe, but am encouraging those who can't eat gluten to be more safe if they can't always be in a situation where they have full control over their food.

[docaz]

9 minutes ago, Scott Adams said:

In summary, AN-PEP has been shown in published scientific studies to break down anywhere between 1/8 to 1/3 of a slice of wheat bread! If that is not the most amazing development that has come along in the treatment of celiac disease and/or gluten sensitivity in the past 25 years, what is? How much cross contamination would you likely get in a restaurant where you might order off a gluten-free menu, or order items you know are naturally gluten-free? What if they cooked your eggs and hash browns on an area where they cooked pancakes, or they cooked a lettuce-wrapped burger on a grill where they toasted wheat buns? What if they pulled the croutons out of a salad they gave you? How much gluten would this be?

Again, I am not encouraging anyone to be unsafe, but am encouraging those who can't eat gluten to be more safe if they can't always be in a situation where they have full control over their food.

This is the paper from clinicians at the University of Chicago Celiac center writing about GliadinX being able to break down "only" 1/8 of a slice of bread (Section 12). As Scott pointed out, that is a huge step forward given that most contamination is a lot less

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024684/

[Tammy1969]

2 hours ago, Scott Adams said:

In summary, AN-PEP has been shown in published scientific studies to break down anywhere between 1/8 to 1/3 of a slice of wheat bread! If that is not the most amazing development that has come along in the treatment of celiac disease and/or gluten sensitivity in the past 25 years, what is? How much cross contamination would you likely get in a restaurant where you might order off a gluten-free menu, or order items you know are naturally gluten-free? What if they cooked your eggs and hash browns on an area where they cooked pancakes, or they cooked a lettuce-wrapped burger on a grill where they toasted wheat buns? What if they pulled the croutons out of a salad they gave you? How much gluten would this be?

Again, I am not encouraging anyone to be unsafe, but am encouraging those who can't eat gluten to be more safe if they can't always be in a situation where they have full control over their food.

I just came across this thread. I’m very interested in more information about the AN-PEP and also I’ve seen things about charcoal tablets. Do you have any specific brands of these supplements or precautionary measures that you recommend? I’m so new to celiac disease that I’m literally afraid to eat almost anything from anyplace other than a pre-packaged certified gluten free food item. It’s been a bit overwhelming to say the least. Thank you so much! 

[docaz]

46 minutes ago, Tammy1969 said:

I just came across this thread. I’m very interested in more information about the AN-PEP and also I’ve seen things about charcoal tablets. Do you have any specific brands of these supplements or precautionary measures that you recommend? I’m so new to celiac disease that I’m literally afraid to eat almost anything from anyplace other than a pre-packaged certified gluten free food item. It’s been a bit overwhelming to say the least. Thank you so much! 

When my kids were diagnosed, I must admit that it was quite overwhelming for me also but it for sure gets easier as you learn how to deal with it. It is easier in urban areas where there are more gluten free restaurants but most supermarkets have lots of gluten free options. 

Regarding AN-PEP, you can go on google scholar and enter the terms: aspergillus niger endopeptidase, gluten and you will find a lot.  I am biased towards GliadinX but you can easily look up the concentration of various AN-PEP (tolerase G) containing products and you will find that GliadinX has by far the highest concentration. In addition, the formula is made to lower the pH to further boost the efficacy. This is based on a study that compared the AN-PEP alone and with an acidic carbonated drink. Charcoal is controversial because the pores are very small and therefore, it can not detoxify gluten but some report that it helps with bloating. I am not an expert in that and others might chime in. 

[docaz]

This is a paper that I just recently discovered by Dr. Stefano Guandalini who is Professor Emeritus and the founder of the University of Chicago Celiac Center.

Please not on the last page before the references the diagram (the image with the scissors) explaining how AN-PEP (GliadinX) works https://www.researchgate.net/profile/Stefano-Guandalini/publication/356538001_Celiac_Disease/links/61fec72bb44cbe4227256a70/Celiac-Disease.pdf

[Jim Rockford]

This product does not work for simple cross-contamination for me.

I don’t intend on doing copious amounts of research trying to justify that enzymes work; I just won’t support or purchase the product.

The fact this product is hyped on this forum so much AND a sponsor is suspect. 
 

 

[Scott Adams]

I'm not sure of how you used it, but it is true that if you got something with a lot of contamination it may not work unless you increase the number of capsules you take. In restaurant situations, even if I order from a gluten-free menu, I typically take two just before eating. Since I've been doing this I've not had gluten issues when eating out, but each situation is different, and my two capsules may not work if I should encounter something with a lot more hidden gluten in it. 

[docaz]

2 hours ago, Jim Rockford said:

This product does not work for simple cross-contamination for me.

I don’t intend on doing copious amounts of research trying to justify that enzymes work; I just won’t support or purchase the product.

The fact this product is hyped on this forum so much AND a sponsor is suspect. 
 

 

Hi,

I am actually the "suspect" sponsor and I have developed the product for my own children based on the existing data and not based on hype but based on collaboration with the former head of the University of Chicago Celiac Center and the head of the GI department at Leiden University who performed some the original studies in 2006.

If the owner of the site, would not have evaluated the real data, he would not put my product anywhere on his site. 

 

After the disappointing outcome of a vaccine study, research has been focusing on reducing the body's inflammatory response and once again on endopeptidases such as GliadinX or Kumamax by Takeda and Latiglutenase by ImmunogenX (currently studies at the Mayo Clinic). Enzymes have been researched since the early 2000s and have been shown to break down the immunogenic component of gluten but got out of favor because several exopeptidases (not endopeptidases) claimed to break down gluten which in fact they do but they do not digest the immunogenic components and therefore the gluten is not detoxified. 

Here is the most recent double-blind placebo study with GliadinX on celiac volunteers. I am privileged to the data but can not post it until it will be published. I can hint that it is quite convincing and I hope that it will help people to have a safer gluten-free lifestyle and alleviate some of the significant stress associated with it:

https://clinicaltrials.gov/ct2/show/record/NCT04788797?view=record

I understand that you do not want to go through a copious amount of research (which is unfortunate because it is easily accessible) but for those who are interested here are some pertinent links to publications in peer-reviewed high-quality professional journals:

https://www.mdpi.com/2072-6643/12/7/2095/htm

https://onlinelibrary.wiley.com/doi/epdf/10.1111/apt.13266

https://www.researchgate.net/publication/6338053_Efficient_degradation_of_gluten_by_a_prolyl_endoprotease_in_a_gastrointestinal_model_Implications_for_coeliac_disease

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.611.8053&rep=rep1&type=pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793137/

 

There are many more publications and you find some of those here

https://www.gliadinx.com/publications

 

 

 

[Jim Rockford]

On 6/1/2023 at 11:41 AM, docaz said:

Hi,

I am actually the "suspect" sponsor and I have developed the product for my own children based on the existing data and not based on hype but based on collaboration with the former head of the University of Chicago Celiac Center and the head of the GI department at Leiden University who performed some the original studies in 2006.

If the owner of the site, would not have evaluated the real data, he would not put my product anywhere on his site. 

 

After the disappointing outcome of a vaccine study, research has been focusing on reducing the body's inflammatory response and once again on endopeptidases such as GliadinX or Kumamax by Takeda and Latiglutenase by ImmunogenX (currently studies at the Mayo Clinic). Enzymes have been researched since the early 2000s and have been shown to break down the immunogenic component of gluten but got out of favor because several exopeptidases (not endopeptidases) claimed to break down gluten which in fact they do but they do not digest the immunogenic components and therefore the gluten is not detoxified. 

Here is the most recent double-blind placebo study with GliadinX on celiac volunteers. I am privileged to the data but can not post it until it will be published. I can hint that it is quite convincing and I hope that it will help people to have a safer gluten-free lifestyle and alleviate some of the significant stress associated with it:

https://clinicaltrials.gov/ct2/show/record/NCT04788797?view=record

I understand that you do not want to go through a copious amount of research (which is unfortunate because it is easily accessible) but for those who are interested here are some pertinent links to publications in peer-reviewed high-quality professional journals:

https://www.mdpi.com/2072-6643/12/7/2095/htm

https://onlinelibrary.wiley.com/doi/epdf/10.1111/apt.13266

https://www.researchgate.net/publication/6338053_Efficient_degradation_of_gluten_by_a_prolyl_endoprotease_in_a_gastrointestinal_model_Implications_for_coeliac_disease

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.611.8053&rep=rep1&type=pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793137/

 

There are many more publications and you find some of those here

https://www.gliadinx.com/publications

 

 

 

That’s great pal. It didn’t (and hasn’t) worked for me. YMMV, OK?

All the studies and factoids do not change my individual results.

 

[Scott Adams]

You haven’t mentioned how you’ve used it, how many capsules you took, etc. More details about that might reveal something that could be helpful to you and others. Can you describe your experience when It didn’t work for you? How much you took, when you took them (hopefully just before eating or with the meal) is helpful info.