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Please help interpret SNPs

Ippodrom234
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Ippodrom234 Newbie
Ippodrom234
Posted

I would like to see if I have any predisposition to celiac based on my raw genetic data. Any help would be highly appreciated.

My results are as follows (based on https://www.geneticlifehacks.com/more-on-the-genetics-of-celiac-disease/  ):

HLA-DQ2.5:

rs2187668  CC (typical (no risk for celiac unless HLA-DQ8)

HLA-DQ8:

rs7454108   TT : typical (no risk for celiac unless HLA-DQ2)

HLA-DQ2.2:

rs4713586   AA HLA-DQ2.2 possible if you also have rs2395182 T, and rs7775228 C

rs2395182   TT : HLA-DQ2.2 possible if you also have rs4713586 A/A, and rs7775228 C

rs7775228   TT not HLA-DQ2.2

Also:

rs3184504   CT increased relative risk of celiac (with HLA type above)

rs2816316   AA increased relative risk of celiac (with HLA type above)

rs917997    CC  no increased risk

rs6441961   CC  no increased risk

rs601338    AG no increased risk

Seems I'm off the hook but wanted to be sure, thanks!

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Scott Adams Grand Master
Scott Adams
Posted

I'm not sure we have any genetic "experts" here who would be able to go into this in detail, but this article has some general info?

It looks like you have the genetic makeup to possibly get celiac disease, but I could not tell your overall risk from what you posted.

Have you spoken to the lab who did the test and gave you these results? They should be able to do that.

 

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