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Celiac?


Scrapmanson

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Scrapmanson Apprentice
1 minute ago, trents said:

Nope, doesn't look like celiac disease but if you have celiac-like symptoms you may very well have NCGS (Non Celiac Gluten Sensitivity).

Thanks,  kinda freaked out with what the other stuff says or means in the biopsy,  tried googling but it's pretty confusing. 

 


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trents Grand Master

Hyperplasia of the Brunner's gland means it is enlarged. These glands reside in the small bowel

"Brunner’s glands are duodenal glands localized predominantly in the submucosa of proximal duodenum. They secrete alkaline fluid composed of mucin (Muc-6) which protects duodenal epithelium by counteracting the acid chime from stomach".

It is possibly working overtime to counteract excess acid in the stomach? Earlier in the thread you describe a problem with burning in your stomach.

Scrapmanson Apprentice
38 minutes ago, trents said:

Hyperplasia of the Brunner's gland means it is enlarged. These glands reside in the small bowel

"Brunner’s glands are duodenal glands localized predominantly in the submucosa of proximal duodenum. They secrete alkaline fluid composed of mucin (Muc-6) which protects duodenal epithelium by counteracting the acid chime from stomach".

It is possibly working overtime to counteract excess acid in the stomach? Earlier in the thread you describe a problem with burning in your stomach.

Thank you! Yeah I get burning in abdomen,  bloating,  abdomen pain,  lots of gas,  my tongue is white and sore... But I don't get acid reflux

trents Grand Master
(edited)
1 hour ago, Scrapmanson said:

Thank you! Yeah I get burning in abdomen,  bloating,  abdomen pain,  lots of gas,  my tongue is white and sore... But I don't get acid reflux

Well, you LES (Lower Esophagial Sphincter) must be sealing the top of the stomach off well and not allowing stomach juices to get up into the esophagus. And there was no mention of a hiatal hernia in the report.

Edited by trents
Courtney541 Rookie
On 6/27/2022 at 4:27 PM, Scrapmanson said:

Hey guys new here, I've flet horrible and can't seem to get any answers, just trying to see if this is possible celiac or something else. So this long road started about 7yrs ago my daughter got real sick and I started having burning stomach and lost some weight and such, so started going to Dr, for blood work and I got fobed off. Well since then I've had more issues and I'm still only diagnosed with gastritis and ibs. About 3 yrs agoI had CT scan all Clear, colonoscopy all clear, endoscopy with biospy showed mild chronic gastritis, blood work always good except slightly high mpv 11.7 with 11.6 as the standard. My symptoms include burning stomach, abdomen pain, back pain, bloating, tons of gas, white tongue, large sticky stool, floating stool, constipation, loose stool, I'm sure a few things I'm missing. Anyways had a celiac blood test done recently, and I'm scheduled for another endoscopy in 2 weeks. Here's my test results. I did go in today and ask for a total iga serum test, waiting on results. Thanks! 

Ttg iga neg .5<15

Ttg igg neg .8<15

Diam igg neg .4<15

Diam iga pos 22.5

I just got my results too and I’m so confused because my Ttg iga was “positive” at 4 because the reference used was weak positive 4-10 

Scrapmanson Apprentice

Well had my appointment yesterday,  Dr said everything is normal..... Like how is that even possible! Now he's thinking either sibo or pancreatic enzyme issues

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    • Scott Adams
      This is a very common question, and the most important thing to know is that no, Guinness is not considered safe for individuals with coeliac disease. While it's fascinating to hear anecdotes from other coeliacs who can drink it without immediate issues, this is a risky exception rather than the rule. The core issue is that Guinness is brewed from barley, which contains gluten, and the standard brewing process does not remove the gluten protein to a level safe for coeliacs (below 20ppm). For someone like you who experiences dermatitis herpetiformis, the reaction is particularly significant. DH is triggered by gluten ingestion, even without immediate gastrointestinal symptoms. So, while you may not feel an instant stomach upset, drinking a gluten-containing beer like Guinness could very well provoke a flare-up of your skin condition days later. It would be a gamble with a potentially uncomfortable and long-lasting consequence. Fortunately, there are excellent, certified gluten-free stouts available now that can provide a safe and satisfying alternative without the risk.
    • MogwaiStripe
      Interestingly, this thought occurred to me last night. I did find that there are studies investigating whether vitamin D deficiency can actually trigger celiac disease.  Source: National Institutes of Health https://pmc.ncbi.nlm.nih.gov/articles/PMC7231074/ 
    • Butch68
      Before being diagnosed coeliac I used to love Guinness. Being made from barley it should be something a coeliac shouldn’t drink. But taking to another coeliac and they can drink it with no ill effects and have heard of others who can drink it too.  is this everyone’s experience?  Can I drink it?  I get dermatitis herpetiformis and don’t get instant reactions to gluten so can’t try it to see for myself. 
    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
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