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Celiac?


Scrapmanson

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Scrapmanson Apprentice
1 minute ago, trents said:

Nope, doesn't look like celiac disease but if you have celiac-like symptoms you may very well have NCGS (Non Celiac Gluten Sensitivity).

Thanks,  kinda freaked out with what the other stuff says or means in the biopsy,  tried googling but it's pretty confusing. 

 


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trents Grand Master

Hyperplasia of the Brunner's gland means it is enlarged. These glands reside in the small bowel

"Brunner’s glands are duodenal glands localized predominantly in the submucosa of proximal duodenum. They secrete alkaline fluid composed of mucin (Muc-6) which protects duodenal epithelium by counteracting the acid chime from stomach".

It is possibly working overtime to counteract excess acid in the stomach? Earlier in the thread you describe a problem with burning in your stomach.

Scrapmanson Apprentice
38 minutes ago, trents said:

Hyperplasia of the Brunner's gland means it is enlarged. These glands reside in the small bowel

"Brunner’s glands are duodenal glands localized predominantly in the submucosa of proximal duodenum. They secrete alkaline fluid composed of mucin (Muc-6) which protects duodenal epithelium by counteracting the acid chime from stomach".

It is possibly working overtime to counteract excess acid in the stomach? Earlier in the thread you describe a problem with burning in your stomach.

Thank you! Yeah I get burning in abdomen,  bloating,  abdomen pain,  lots of gas,  my tongue is white and sore... But I don't get acid reflux

trents Grand Master
(edited)
1 hour ago, Scrapmanson said:

Thank you! Yeah I get burning in abdomen,  bloating,  abdomen pain,  lots of gas,  my tongue is white and sore... But I don't get acid reflux

Well, you LES (Lower Esophagial Sphincter) must be sealing the top of the stomach off well and not allowing stomach juices to get up into the esophagus. And there was no mention of a hiatal hernia in the report.

Edited by trents
Courtney541 Rookie
On 6/27/2022 at 4:27 PM, Scrapmanson said:

Hey guys new here, I've flet horrible and can't seem to get any answers, just trying to see if this is possible celiac or something else. So this long road started about 7yrs ago my daughter got real sick and I started having burning stomach and lost some weight and such, so started going to Dr, for blood work and I got fobed off. Well since then I've had more issues and I'm still only diagnosed with gastritis and ibs. About 3 yrs agoI had CT scan all Clear, colonoscopy all clear, endoscopy with biospy showed mild chronic gastritis, blood work always good except slightly high mpv 11.7 with 11.6 as the standard. My symptoms include burning stomach, abdomen pain, back pain, bloating, tons of gas, white tongue, large sticky stool, floating stool, constipation, loose stool, I'm sure a few things I'm missing. Anyways had a celiac blood test done recently, and I'm scheduled for another endoscopy in 2 weeks. Here's my test results. I did go in today and ask for a total iga serum test, waiting on results. Thanks! 

Ttg iga neg .5<15

Ttg igg neg .8<15

Diam igg neg .4<15

Diam iga pos 22.5

I just got my results too and I’m so confused because my Ttg iga was “positive” at 4 because the reference used was weak positive 4-10 

Scrapmanson Apprentice

Well had my appointment yesterday,  Dr said everything is normal..... Like how is that even possible! Now he's thinking either sibo or pancreatic enzyme issues

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    • xxnonamexx
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    • trents
      So the tTG-IGA at 28 is positive for celiac disease. There are some other medical conditions that can cause elevated tTG-IGA but this is unlikely. There are some people for whom the dairy protein casein can cause this but by far the most likely cause is celiac disease. Especially when your small bowel lining is "scalloped". Your Serum IGA 01 (aka, "total IGA") at 245 mg/dl is within normal range, indicating you are not IGA deficient. But I also think it would be wise to take your doctor's advice about the sucraid diet and avoiding dairy . . . at least until you experience healing and your gut has had a chance to heal, which can take around two years. After that, you can experiment with adding dairy back in and monitor symptoms. By the way, if you want the protein afforded by dairy but need to avoid casein, you can do so with whey protein powder. Whey is the other major protein in dairy.
    • jenniber
      hi, i want to say thank you to you and @trents   . after 2 phone calls to my GI, her office called me back to tell me that a blood test was “unnecessary” and that we should “follow the gold standard” and since my biopsy did not indicate celiac, to follow the no dairy and sucraid diet. i luckily have expendable income and made an appt for the labcorp blood test that day. i just got my results back and it indicates celiac disease i think 😭   im honestly happy bc now i KNOW and i can go gluten free. and i am SO MAD at this doctor for dismissing me for a simple blood test that wouldn’t have cost her anything !!!!!!!!!!! im sorry, im so emotional right now, i have been sick my whole life and never knew why, i feel so much better already   my results from labcorp:   Celiac Ab tTG TIgA w/Rflx Test Current Result and Flag Previous Result and Date Units Reference Interval t-Transglutaminase (tTG) IgA 01 28 High U/mL 0-3 Negative 0 - 3 Weak Positive 4 - 10 Positive >10 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy. Immunoglobulin A, Qn, Serum 01 245 mg/dL 87-352
    • JoJo0611
      Thank you this really helped. 
    • Samanthaeileen1
      Okay that is really good to know. So with that being positive and the other being high it makes sense she diagnosed her even without the endoscopy. So glad we caught it early. She had so many symptoms though that to me it was clear something was wrong.   yeah I think we had better test us and the other kids as well. 
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