Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Help interpreting blood test results?

sunflowers
 Share

Recommended Posts

sunflowers Rookie
sunflowers
Posted

Hi there - I need some help/support in interpreting my blood test results. For some background, I have been experiencing anemia and GI issues my entire life and began investigating in 2014. I was told it was just anxiety, depression, my period, stress. Only recently did a general practitioner by chance do a B12 test but "it's probably just depression." 🙄 So, I found out I'm deficient in B12 (184) and she referred me to a GI. There, I had to press the GI to do a celiac panel because I wanted to find the cause of the B12 deficiency. 

Anyway, the results came back and I'm only elevated in DGP-IgG. My results are 204.5 when the reference range is <14.9. Everything else was negative, and I don't appear to be deficient in IgA, my results are 245 and the reference range is 81-463. 

I have all the classic symptoms of celiac disease. For example, within 15-20 minutes of consuming gluten I'm bloated beyond belief, nauseous, brain fog, fatigued, abdominal pain. I vomit every morning if I had gluten the day before. I also have all the classic loose stool/constipation symptoms for as long as I can remember. 

If it's not celiac disease because I only tested positive on one test, what's causing me to feel like crap my whole life? 

Also, I do have an endoscopy and colonoscopy scheduled for 3 weeks from now and I have not stopped eating gluten just in case. And I continue to feel like a dumpster fire. 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


trents Grand Master
trents
Posted

Welcome to the forum, sunflowers!

We here many stories on this forum that mirror yours. That is to say, only one test in the celiac panel turns out positive. But that's why they run the multiple tests that make up the panel and not just one or the other. I do believe you have celiac disease based on the symptoms and the testing. We also get people who test positive on the celiac panel (even tTG-IGA) but have negative biopsies. And then we have people with positive biopsies but all negatives on the celiac panel. No one testing method seems to be absolutely foolproof. 

sunflowers Rookie
sunflowers
Posted
  • Author
2 minutes ago, trents said:

Welcome to the forum, sunflowers!

We here many stories on this forum that mirror yours. That is to say, only one test in the celiac panel turns out positive. But that's why they run the multiple tests that make up the panel and not just one or the other. I do believe you have celiac disease based on the symptoms and the testing. We also get people who test positive on the celiac panel (even tTG-IGA) but have negative biopsies. And then we have people with positive biopsies but all negatives on the celiac panel. No one testing method seems to be absolutely foolproof. 

Hi and thank you for the reply!! I was totally misinformed then! I thought that you had to receive a positive on multiple or all to have celiac. 

knitty kitty Grand Master
knitty kitty
Posted

@sunflowers,

Welcome to the forum!

Anemia can affect the production of white blood cells (and thus antibody production) as well as the production of red blood cells.  

We've had several members who reported as positive on only the DPG.  Don't worry, we'll still let you in the Celiac club.

Keep us posted on your endoscopy results!  

  • 4 weeks later...
sunflowers Rookie
sunflowers
Posted
  • Author

Update: recieved my endoscopy results. Doctor said she saw inflammation in my stomach and esophagus, but the biopsy was negative for celiac. I'm also positive for SIBO. So doctor is telling me that I don't have celiac disease based on the negative biopsy results. What else might cause elevated DGP levels? I've been gluten free about 2 weeks and I feel better, so diagnosis or not I'm going to stick with it. 

trents Grand Master
trents
Posted

What can mimic celiac disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587842/

 

Gluten containing grains will be high in carbs and would feed into the SIBO issue.

knitty kitty Grand Master
knitty kitty
Posted

@sunflowers,

Glad you're feeling better! 

Were the biopsy samples examined by a pathologist?

How many biopsy samples were taken?

Damage to the small intestine can be patchy and the initial changes with Celiac can be microscopic.  

Have you had genetic testing done to check for the most common Celiac genes?

What recommendations did the doctor give for the SIBO?  

I went on the AIP diet (Autoimmune Paleo Protocol diet) and had great results.  The AIP diet starves out the SIBO bacteria.  Stay away from anything with high fructose corn syrup!  

Thanks for the update!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      126,836
    • Most Online (within 30 mins)
      7,748
    Art Glassman
    Newest Member
    Art Glassman
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.7k
  • Celiac.com Sponsor (A22):



  • Who's Online (See full list)

    • There are no registered users currently online
  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • knitty kitty
      Guidance on next steps after the lab tests

      By knitty kitty · Posted

      @ABP2025, Here's some studies and articles that will help you learn more about thiamin and all... I will write more later. It's possible that your antibiotic for giardiasis has caused thiamine deficiency.   https://hormonesmatter.com/metronidazole-toxicity-thiamine-deficiency-wernickes-encephalopathy/ And... https://hormonesmatter.com/thiamine-deficiency-testing-understanding-labs/ And... Thiamine and benfotiamine: Focus on their therapeutic potential https://pmc.ncbi.nlm.nih.gov/articles/PMC10682628/ and... Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/31746327/      
    • DayaInTheSun
      Being a burden to family/friends

      By DayaInTheSun · Posted

      Interesting you mention MCAS. I have come across mcas before but I wasn’t entirely sure if that’s what it was. When I eat certain food like dairy or soy my face gets so hot and I feel flush and my heart rate shoot’s up. And sometimes my bottom lip swells or I get hives somewhere. This started happening after I had a really bad case of Covid.  Before that I was able to eat all those things (minus gluten) I was diagnosed with celiac way before I had Covid.  Hmm, not sure really. I may look for a different allergist my current one told me to take Zyrtec and gave me an epi pen. 
    • Kiwifruit
      Years of testing - no real answers

      By Kiwifruit · Posted

      This is all really useful information, thank you so much to you both.    I have a history of B12 and vit D deficiency which has always just been treated and then ignored until it’s now again.
    • trents
      9 Year Old test results - help interpret

      By trents · Posted

      Welcome to the forum, @Gill.brittany8! There are two main genes that have been identified as creating potential for developing celiac disease, HLDQ2 and HLDQ8. Your daughter has one of them. So, she possesses genetic the potential to develop celiac disease. About 40% of the general population carries one or both of these genes but only about 1% of the general population develops celiac disease. It takes both the genetic potential and some kind of triggering stress factor (e.g., a viral infection or another prolonged health problem or an environmental factor) to "turn on" the gene or genes. Unfortunately, your daughter's doctor ordered a very minimal celiac antibody panel, the tTG-IGA and total IGA. Total IGA is not even a test per celiac disease per se but is a check for IGA deficiency. If the person being checked for celiac disease is IGA deficient, then the scores for individual IGA tests (such as the tTG-IGA) will be abnormally low and false negatives can often be the result. However, your daughter's total IGA score shows she is not IGA deficient. You should consider asking our physician for a more complete celiac panel including DGP-IGA, TTG_IGG and DGP-IGG. If she had been avoiding gluten that can also create false negative test results as valid antibody testing requires having been consuming generous amounts of gluten for weeks leading up to the blood draw. Do you know if the GI doc who did the upper GI took biopsies of the duodenum and the duodenum bulb to check for the damage to the small bowel lining caused by celiac disease? Having said all that, her standard blood work shows evidence of possible celiac disease because of an elevated liver enzyme (Alkaline Phosphatase) and low values for hemoglobin.
    • Gill.brittany8
      9 Year Old test results - help interpret

      By Gill.brittany8 · Posted

      Hi everyone  After years of stomach issues being ignored by doctors, my 9 y/o daughter finally had an upper endoscopy which showed a ton of stomach inflammation. The GI doctor ordered some bloodwork and I’m attaching the results here. Part will be from the CBC and the other is celiac specific. I’m not sure what’s relevant so I’m just including extra information just in case.   The results are confusing because they say “No serological evidence of celiac disease. tTG IgA may normalize in individuals with celiac disease who maintain a gluten-free diet. Consider HLA DQ2 and DQ8 testing to rule out celiac disease.” But just a few lines down, it says DQ2 positive. Can someone help make sense of this? Thanks so much.  result images here: https://ibb.co/WFkF0fm https://ibb.co/kHvX7pC https://ibb.co/crhYp2h https://ibb.co/fGYFygQ  
×
×
  • Create New...