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Please help me interpret my blood results! (Possible Diagnosis)

granolagoddess1
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granolagoddess1 Newbie
granolagoddess1
Posted

Hello! I have been having gastrointestinal issues + fatigue for years, so finally decided to get bloodwork done. I was told my celiac diagnostic panel was positive, indicating a high likelihood of me having celiac. My questions are: 

1. What are the chances of me actually having celiac based on my bloodwork + some of the tests coming back "normal?" 

2. Should I continue eating gluten prior to my endoscopy? 

 

Thank you :)

 

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granolagoddess1 Newbie
granolagoddess1
Posted
  • Author
2 minutes ago, granolagoddess1 said:

Hello! I have been having gastrointestinal issues + fatigue for years, so finally decided to get bloodwork done. I was told my celiac diagnostic panel was positive, indicating a high likelihood of me having celiac. My questions are: 

1. What are the chances of me actually having celiac based on my bloodwork + some of the tests coming back "normal?" 

2. Should I continue eating gluten prior to my endoscopy? 

 

Thank you :)

EDIT: Here are my bloodwork results: 

- Tissue transglutimase Ab, IgG - Normal / antibody not detected 

- Tissue transglutimase Ab, IgA - High (38.2) / antibody detected 

- Gliadin (deamidated) Ab (IgA) - High (15.5) / antibody detected 

- gliadin (deamidated) Ab (IgG) - Normal (4.6) 

- Immunoglobulun A - Normal 

2 minutes ago, granolagoddess1 said:

 

 

trents Grand Master
trents
Posted

The chances are high that you have celiac disease. The centerpiece of the antibody testing you had done is the tTG-IGA and it is positive. It would have been more helpful if you had included the reference ranges for each test as different labs use different reference ranges for positive vs. negative. or high vs. normal in this case. You also have a positive for deamidated IGA. The Immunoglobulun A is not a celiac antibody test per se but a measure of total antibodies. If that one is low (which it is not) it can skew the individual celiac antibody tests toward negative. It is common for people with celiac disease to test negative for all antibody tests as some of the tests are less sensitive than others (and some are more specific than others). 

Yes, you should definitely continue to eat normal amounts of gluten (the equivalent of at least two slices of wheat bread daily) until you have the endoscopy/biopsy. 

Scott Adams Grand Master
Scott Adams
Posted

I agree, and given that you have two high blood test results for celiac disease, you likely have it, especially given your symptoms. Has your doctor discussed your results with you yet?

trents Grand Master
trents
Posted

I corrected something I said as I typed something other than what I meant to say. Please see the underlined portions in my first post.

Kate333 Rising Star
Kate333
Posted

Yes...you need to keep eating G before your endoscopy to ensure its accuracy.  

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