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DQ2.2 Homozygous

BushbabyLou
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BushbabyLou Rookie
BushbabyLou
Posted

Hi, 

 

can someone please help me to decipher my nutrahacker results? I have also done a Randox gene test which told me I have HLQ-DQA1*03. Does this and my nutrahacker results suggest I may have a disposition to celiac disease? I have my endoscopy next week to determine whether I actually have it. 
 

TIA46305875-F14A-4151-891F-F65DC291F201.webp.5b9ddff7bb7ddc7b8f17bc37b6a9ae16.webp

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Scott Adams Grand Master
Scott Adams
Posted

I can't read the results that are cut off below the first table, but it looks like you are positive on the very top line of the first table, the DQ2.2, is that correct? 

I am no genetic expert on your exact risk, but the company who did this test should be able to give you that info. Have you contacted them about your results?

BushbabyLou Rookie
BushbabyLou
Posted
  • Author
21 minutes ago, Scott Adams said:

I can't read the results that are cut off below the first table, but it looks like you are positive on the very top line of the first table, the DQ2.2, is that correct? 

I am no genetic expert on your exact risk, but the company who did this test should be able to give you that info. Have you contacted them about your results?

Hi, thank you for you reply. That’s what I thought. I will try contacting them but they don’t really offer a consultation service. I have my endoscopy Wednesday so might as well just wait for the results of that.

Scott Adams Grand Master
Scott Adams
Posted

Sure, have you been eating ~2 slices worth of wheat bread or equivalent for the last couple of weeks? This is required before an endoscopy for celiac disease. Let us know how it goes!

JD-New to Celiac Explorer
JD-New to Celiac
Posted
On 8/17/2022 at 12:18 PM, BushbabyLou said:

Hi, 

 

can someone please help me to decipher my nutrahacker results? I have also done a Randox gene test which told me I have HLQ-DQA1*03. Does this and my nutrahacker results suggest I may have a disposition to celiac disease? I have my endoscopy next week to determine whether I actually have it. 
 

TIA46305875-F14A-4151-891F-F65DC291F201.webp.5b9ddff7bb7ddc7b8f17bc37b6a9ae16.webp

I had my genetic testing done as well although the results were not quite as detailed as yours are. I did post them on this site but did not get any response. I have to assume that most do not have this testing done. Like you I was lost at what the results meant so I reached out to the online lab I used to get them done and the reply is that they are not medical doctors and cannot diagnose or interrupt the results. I did an exhausting online search and found genetic test results to be confusing. I pulled this from one of those searches...

To explain the genes that are associated with celiac disease, I've taking excerpts from About.com -

Jane Anderson's Gluten Sensitivity and Celiac Disease: Celiac Disease Genetic Testing:

"The genes that predispose you to celiac disease are located on the HLA-class II complex of our DNA, and they're known as the DQ genes. Everyone has two copies of a DQ gene - one from their mother and one from their father. There are numerous types of DQ genes, but there are two that are involved in the vast majority of celiac disease cases: HLA-DQ2 and HLA-DQ8".

HLA-DQ2

"People who have two copies of HLA-DQ2 (a very small percentage of the population) carry the highest overall risk for celiac disease. People who are HLA-DQ2 homozygous also have an increased risk for at least one type of refractory celiac disease (which occurs when the gluten-free diet doesn't seem to work to control the condition), and for enteropathy-associated T-cell lymphoma, a type of cancer that's associated with celiac disease."

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