magnesium deficiency Magnesium Deficiency and High Histamine Levels could it be causing your Allergies?

[Posterboy]

To All,

I came across this article and research and haven't been able to post it till now and I thought it deserved it's on thread topic.  I will probably post in the Magnesium, Magnesium, Magnesium thread at a later date.

Maybe it will help some one else.

https://blog.organicolivia.com/magnesium-deficiency-associated-high-histamine-levels-allergies/

And this research they quoted entitled "Blood and mast cell histamine levels in magnesium-deficient rats"

https://pubmed.ncbi.nlm.nih.gov/6445415/

Where they note Histamine Levels are elevated to 6 to 7X compared to a healthy person with normal Magnesium levels.

There seems to be an direct relationship (IMHO) between a Magnesium deficiency and a disordered immune systems IE a Magnesium deficiency could be the trigger for a Histamine Intolerance leading to a Histamine Storm...

This would explain well this research as well entitled  "Effects of magnesium deficiency on dermal mast cells in rats]"

https://pubmed.ncbi.nlm.nih.gov/2438197/

I hope this is helpful but it is not medical advice.

Posterboy,

[trents]

I'm reasonably certain that I suffer from histamine intolerance but I already supplement with magnesium. I think my issue is probably insufficient DAO production. A couple of days ago I started on a DAO supplement and I am bumping up my zyrtec from one to two tabs daily. Next time I get to Costco I'm switching to Allegra 24 hr. as their new formulation is the only third gen antihistamine you can get over the counter. I seem to always get congested at night while sleeping and this causes terrific headaches/migraines. I'm also attempting to eat lower histamine but that as a singular approach is not going to do the job. So many, many healthful foods are high in histamines. And our first world food supply system depends heavily on canned and preserved foods as opposed to fresh.  Copper insufficiency can also contribute to low DOA levels but copper deficiency is pretty rare.

Edited August 18, 2022 by trents

[Posterboy]

Trents,

Taking Niacin (not Niacinamide) can help flush out the histamine in your cells.

Niacin and Magnesium are power tools against Histadelia (aka a Histamine Intolerance).

Here is the research on it from 20+ years ago.

http://orthomolecular.org/library/jom/2002/pdf/2002-v17n01-p017.pdf

It shows how the Use of Niacin treats a “Histamine Intolerance”…..

quoting from the PDF

“Using niacin to treat histadelia might seem contradictory considering it will aug[1]ment the release of histamine from basophils and tissue mast cells.11 However, there is evidence that the niacin flush is mediated by the release of prostaglandin D2 (PGD2) from dermal macrophages and not from degranulation of basophil and tis[1]sue mast cells.12,13 Further, Hoffer suggested that daily intake of niacin gradually lowers total body histamine by chronically deplet[1]ing storage levels.1

Niacin has a compli[1]cated mechanism of action that modulates histamine release, lowers total blood hista[1]mine, and increases the production of PGD2….

The Niacinamide form of vitamin B3 (nicotina[1]mide or niacinamide) does not directly pro[1]mote the degranulation of histamine contain[1]ing cells, deplete tissue stores, or increase PGD2 release. Nicotinamide might function primarily by reducing the histaminergic re[1]sponse to antigenic stimulation.”

Embrace the Niacin Flush and you will find it helps your "Itchy, Scatchy" problems....and seasonal allgeries.

Here is a nice oveview on why the Niacin flush is good for seasonal allergies.

http://getwellstaywellathome.com/blog/2015/06/seasonal-allergies-and-the-niacin-flush/

Good luck on your continued journeys!

I hope this is helpful but it is not medical advice.

2 Timothy 2:7 "Consider what I say; and the Lord give thee understanding in all things." this included.

Posterboy by the grace of God,

[trents]

I did increase my magnesium supplementataion, Posterboy. When I trialed a 500 mg Niacinamide supplement it gave me a gut ache a year or so ago. It was manufactured on equipment that also was used for wheat products so the real issue may have been CC. So, you're suggesting the nicotinic acid form, correct?

Actually, the changes I have made so far with upping magnesium, upping zyrtec from 10-15 mg daily and taking the DAO supplement seems to be working for the headaches. I tested positive for COVID last week so still trying to get back to normal from that. Pretty much like a bad cold. They put me on an antiviral called Paxlovid and the med itself can make you feel punk so it's hard to sort out what's what right now. I'm much better than I was at the end of last week, however.

[Posterboy]

21 minutes ago, trents said:

I did increase my magnesium supplementataion, Posterboy. When I trialed a 500 mg Niacinamide supplement it gave me a gut ache a year or so ago. It was manufactured on equipment that also was used for wheat products so the real issue may have been CC. So, you're suggesting the nicotinic acid form, correct?

Trents,

For the High Histamine Levels yes the Niacin aka Nicotinic Acid works best!

I think of Niacin working from the Outside In......best for somebody already having Skin issues like rashes, Psorsias, Atopic Dermatitis etc.

I wrote about the differenc kinds (forms of Niacin) and why frequency is more important than dosage amounts in this Posterboy blog post.  It will probably help you to at least skim it....

It keeps me from having to type everything out so much.....each time.

Note: Niacin WILL flush you!.......as long as you know it is going to happen.....you should be fine with it....

The Niacinamide will not flush you and works from the Inside out.......helping you with your low stomac acid....

I saw in another post/thread you had tappered back/off of your PPIs but were still having some issues with trigger foods....

Taken frequently (IE with Meals) for about 3 months will help you get over your flare ups from stepping off the PPIs.

You can also google for the Niacinamide Challenge and it should come as well it will also summarize what I hav said here....

It almost always works in about 3 months time when someone has stepped back off their PPIs the way you have....

You will notice an incessant and forceful burping that begin slowlyt after say 6 weeks of taking Niacin and/or Niacinamide......both will do the same thing.

And it actually OK to do both kinds if you would like too..... Low dose Niacin (100mg titrated up in larger doses)  works well with Niacin always taken with food (to mitigate the Niacin Flush)......

Each succeding dose will flush.....less and less......until it won't hardly bother you after a week or two.....because you have now "flushed out" your histamine reserves in the skin...

the Niacinamide can be taken without food so......it works well between meals and at night time.

The more frequently you take it (Niacin or NIacinamide) the quicker it will help you!

Usually 6 weeks produces regular burping when taken at least 2/day but 3/day will work 50 percent quicker than 2x a day (you get the idea) .......and after 3 months produces a "Sustained Burping" being your "New Normal" if it is not already.

When you can burp 2 hours after your meal.....your now strong stomach acid is working again to cut up proteins in your diet!

If you done the hard part most people never get off the PPIs  in the first place.

Now you just need to commit the "Niacin(amide) Challenge" and see how much bettter you  feel in 3 or 4 months!

I think you will be amazed how much better your GI tract treats you!

I summarized some of the same things in this posterboy blog post too that explains why NCGS is diagnosed when we get low in Stomach Acid.

After 3 months if you are not already taken a Multivamin it would be good to begin taken one again.....when you can burp 2 hours after your meal......you will much better absorb your other B-Vitamins and your minerals again....

What the stoamch can't dissovle with strong acid our Villi can't absorb in the Small Intestine!

I hope this is helpful but it is not medical advice.

2 Corinthians (KJV) 1:3,4  3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble (starfish), by the comfort wherewith we ourselves are comforted of God.”

Posterboy by grace of God,

[trents]

I am getting about 50mg of niacinamide daily between my multi and my B-complex. I am also taking warfarin and am aware that it there are drug interaction precautions associated with niacin/niacinamide supplementation while taking warfarin so I think I'll stand pat on what I'm doing now. Thanks for the input.

[Rogol72]

I understand the caffeine in tea and coffee and other caffeinated beverages is thought to inhibit the production of DAO enzyme levels in the gut, and well as depleting B Vitamins. I also came across some research regarding deficiencies in Iron and Zinc (in addition to Magnesium) which can also reduce the DAO levels in the gut. I've taken a multipronged approach to resolving my HI issues, and it's working ... being careful of the consumption of high Histamine foods and histamine liberators and addressing mineral deficiencies which has really helped.

[trents]

5 hours ago, Rogol72 said:

I understand the caffeine in tea and coffee and other caffeinated beverages is thought to inhibit the production of DAO enzyme levels in the gut, and well as depleting B Vitamins. I also came across some research regarding deficiencies in Iron and Zinc (in addition to Magnesium) which can also reduce the DAO levels in the gut. I've taken a multipronged approach to resolving my HI issues, and it's working ... being careful of the consumption of high Histamine foods and histamine liberators and addressing mineral deficiencies which has really helped.

The multi-pronged approach is always the best. Personally, I find the low histamine diet quite impractical, nearly impossible. It excludes too many nutritious foods. It may be too early to tell but so far, the DAO supplementation combined with increasing my mag and a tad increase in my zyrtec seems to be working. No migraines in about a week and much less nasal and sinus congestion. If the real problem is under production of DAO why not just supplement that - if it works. Seems like the simplest, most direct approach. DAO supplements are not cheap, however. 

You can also make your own DAO supplement from food grade green pea sprouts but it involves a lot of fussing.

[knitty kitty]

This article about DAO is really interesting.  I found the part about how certain vitamin and mineral deficiencies can affect DAO production in the body.

https://mthfrsupport.com.au/2016/09/dao-deficiency-and-histamine-the-unlikely-connection/

[Posterboy]

On 8/30/2022 at 11:43 PM, trents said:

I am getting about 50mg of niacinamide daily between my multi and my B-complex. I am also taking warfarin and am aware that it there are drug interaction precautions associated with niacin/niacinamide supplementation while taking warfarin so I think I'll stand pat on what I'm doing now. Thanks for the input.

Trents,

 I see this alot....

One of the worst things that ever happened to Niacin was the use of "Slow Niacin" to reduce the flushing that is a healthy natural response to Niacin....

50 mg is probably not high enough to do you any good.....unless you are willing to take it more frequently.

If you do research on blood thinners the active form of B-3 aka Niacin never comes up as a modulator/adverse reactions with Warfarin...

https://depts.washington.edu/anticoag/home/content/warfarin-drug-interactions

Vitamin K and Vitamin E come up but not Niacin....

The "Skin Therapy Letter/Journal" notes the same thing......the clinical uptake/use of Niacinamide is slow despite it very safe profile to treat skin conditions etc...

See this research entitled "Nicotinamide: An Update and Review of Safety & Differences from Niacin"

https://pubmed.ncbi.nlm.nih.gov/33196157/

Where they say quoting

"Nicotinamide (or niacinamide), a form of vitamin B3 that is often confused with its precursor nicotinic acid (or niacin), is a low-cost, evidence-based oral treatment option for actinic keratosis, squamous cell carcinomas, basal cell carcinomas, and bullous pemphigoid. Despite its favorable safety profile and affordability, the integration of nicotinamide into clinical practice is an ongoing process, and like many over-the-counter supplements it has faced some barriers."

So I understand your reluctance it is only natural....

The previous studies on Slo-Niacin have at best been spotty.....due to the fact it blocks the flushing (that is so healthy about Niacin) in the first place.

This exhaustive article explains why the "Niacin Flush" could be very healthy for you.

https://life-enhancement.com/pages/why-the-niacin-flush-may-be-surprisingly-beneficial-to-your-health

I think you saw this article/reseasch on Slo-Niacin aka Extended Release Niacin and reasonably become concerned...

Entitled "Critically elevated INR in a patient on warfarin after increase in extended-release niacin dose"

https://pubmed.ncbi.nlm.nih.gov/22010004/

But it should be noted this was  not from the Natural form of the Vitamin aka Nicotinic Acid commonly called Vitamin B3 or the Niacinamide form of the Vitamin.

And only then in dose above 500mg for more t han 3 months....

Taking 100mg 3x  a day of Niacin is well below that threshold and not in the Slo-Niacin form that was the trigger for this study.

What has happened is we have transferred what happened in the Slow Niacin study to the Vitamin itself and not considering the healthy effect that comes from the flushing itself like the release of built up Histamines....

What people haven't read or don't consider or know is that when Naicin in its natural form is used.....there is actually a health benefit (Even when taken with Warfarin) for clotting factors.

See this ADMIT study about it...entitled "Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT)"

https://pubmed.ncbi.nlm.nih.gov/11011338/

quoting

"Unexpectedly, niacin treatment also resulted in significant decrease in both fibrinogen (48 mg/dL; P <.001) and F1.2 (P =.04). von Willebrand factor increased after antioxidant vitamin treatment (P =.04)."

They also note in their conclusion quoting again...

"Niacin also favorably modifies fibrinogen and plasma F1.2. Niacin, in addition to its lipid effects, modifies abnormal coagulation factors that accompany PAD."

Powerful evidince IMO at least in low doses the Niacin regimen seems to be safe and almost all every body remembers is the "Slow Niacin" study which stunts/restricts/controls this unigue Niacin feature (not well understood feature) known as the Niacin flush that is healthy for us....and only when it is muted or controlled/blunted do the bad side affects from Niacin seem to occur and note: Niacinamide does not seem to have none of these same side affects common to Niacin but all the benefits of Niacin and why I often recommend the Niacinamide form in the first place.....

Because it can be too hard to explain to others.....why the flushing of Niacin is helpful and healthy for a normal person.

IN Fact, if you don't flush when taking Niacin.....it can be an ominious sign for your long term mental health so prominent is the flush with Niacin it used to predict mental health when  healthy people do not flush when taking Niacin!

https://scitechdaily.com/some-people-with-schizophrenia-may-simply-have-a-vitamin-deficiency/

And while we are talking about interactions with Warfarin you should know if you don't know already (or anybody else following this thread) a negative outcome has been recorded for Glucosamine Chondrotion

See this research about it entitled "Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database"

https://pubmed.ncbi.nlm.nih.gov/18363538/

Good luck on your contineud journeys!

As always 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

I hope this is helpful but it is not medical advice.

Posterboy by the grace of God,

[trents]

You must be related to the Apostle Paul when it comes to run on sentences: 

"Powerful evidince IMO at least in low doses the Niacin regimen seems to be safe and almost all every body remembers is the "Slow Niacin" study which stunts/restricts/controls this unigue Niacin feature (not well understood feature) known as the Niacin flush that is healthy for us....and only when it is muted or controlled/blunted do the bad side affects from Niacin seem to occur and note: Niacinamide does not seem to have none of these same side affects common to Niacin but all the benefits of Niacin and why I often recommend the Niacinamide form in the first place....."

Would you unpack that section I underlined? It is confusing with that double negative.

[Posterboy]

Trents,

I was referring to how the Niacin flush was healthy as demonstrated by this exhaustive article that explains in more detail why the Niacin flush shouldn't be blocked......

https://life-enhancement.com/pages/why-the-niacin-flush-may-be-surprisingly-beneficial-to-your-health

But if you are worried about Niacin (despite no study that shows regular Flushing Niacin aka Nicotinic acid) negatively effecting Warfarin use....then just use the Niacinamide form.

The reason Niacinamide doesn't flush is because It doesn't work through the liver the was Niacin does.....

Both (forms) are considered Vitamin B-3 in the body.

Essentialy Niacinamide has all the same benefits as Niacin without any of the possible hangups Niacin can cause in higher doses etc....

Niacinamide is the natural, healthy form of Niacin in the body.  Kind of like the difference between us taking  Folic acid and Folate in the body.

It is the bodies conversion of Niacin to Niacinamide that causes the flushing and why taking Niacinamide avoids the flushing of Niacin.

But note because Niacinamide does not flush.....it will not postively affect your Cholesterol levels!

The Cholesterol benefit only comes with the Niacin form of the Vitamin.

I hope this is helpful but it is not medical advice.

Posterboy,

[trents]

I'm not really concerned about its effect on cholesterol. My concern is which one will have the most postive effect for lowering  histamine levels, if either.

[Rogol72]

I've read that Quercetin is good for addressing high histamine levels. I don't have any personal experience with it, but it may be another piece in the histamine equation.

 

[Beverage]

I've had fantastic results with the flush form of niacin, increased energy, strength, overall health, skin younger, feel younger, better sleep, and sinuses much more open, asthma gone. Quercetin didn't do anything for me.

[trents]

So my Amazon order of nicotinic acid just arrived and the caplets are 100mg each. But I'm reading all over the place that 35mg daily is the safe upper limit for niacin: https://www.hsph.harvard.edu/nutritionsource/niacin-vitamin-b3/#:~:text=UL%3A The Tolerable Upper Intake,19%2B years is 35 milligrams.

[Beverage]

31 minutes ago, trents said:

So my Amazon order of nicotinic acid just arrived and the caplets are 100mg each. But I'm reading all over the place that 35mg daily is the safe upper limit for niacin: https://www.hsph.harvard.edu/nutritionsource/niacin-vitamin-b3/#:~:text=UL%3A The Tolerable Upper Intake,19%2B years is 35 milligrams.

I started at 100mg nicotinic acid. The first time, the flush was very strong, but got less each day. I took 1500mg after I got covid, and recovered very quickly. Now I take 1000mg about 5 days a week. 

Double check your niacin. Make sure it does not say anything slow release...check the reviews on Amazon and if people are complaining about the flush, then you have the right one.

[Beverage]

Nicotinic acid has been used in naturopathic med for a long time. For cholesterol, they commonly say 2000mg. Lots of studies with higher doses. I've read a lot of studies, and many are not clear on the form, they confuse slow release issues, or niacinamide. I know many taking higher doses for years with only improvement in overall health. 

Also a Celiac's friend has tried a few large doses after accidental glutening, and says she recovered a lot faster. 

[Posterboy]

1 hour ago, trents said:

So my Amazon order of nicotinic acid just arrived and the caplets are 100mg each. But I'm reading all over the place that 35mg daily is the safe upper limit for niacin: https://www.hsph.harvard.edu/nutritionsource/niacin-vitamin-b3/#:~:text=UL%3A The Tolerable Upper Intake,19%2B years is 35 milligrams.

 

1 hour ago, Beverage said:

Nicotinic acid has been used in naturopathic med for a long time. For cholesterol, they commonly say 2000mg. Lots of studies with higher doses. I've read a lot of studies, and many are not clear on the form, they confuse slow release issues, or niacinamide. I know many taking higher doses for years with only improvement in overall health. 

Also a Celiac's friend has tried a few large doses after accidental glutening, and says she recovered a lot faster. 

Trents and Beverage Et Al,

I would of responded before now but I have had a lot of things going on lately....

Beverage is right.....the Niacin form is what you want!  I will try and respond in more details in a few days,,,,,if thing setttle down a little....

The 35mg of Niacin is enough to create a flush and how they set there upper tolerable limit.......and why B-Complexs often have the Niacinamide form of Vitamin B-3.

There is a difference between that and a "Safe Amount".

See this discussiona about it....that should answer most of your questions....

"7.3. Safety considerations
The Council for Responsible Nutrition (i.e., CRN) identifies a lowest-observedadverse-
effect level (LOAEL) of 1,000 mg/day corresponding to oral intake of
immediate-release NA (Nicotinic Acid) [73]. Estimated regimens established in this report to
provide health restoration and/or to protect against COVID-19 infection onset are
more than just well tolerated. Given the water solubility of NA (Nicotinic Acid) and its ability to
readily dump (up to 4-5 g at-once) through the liver to then spread ubiquitously
through the cellular systems [73], maintaining higher dose/dosage of immediaterelease
NA eclipsing the LOAEL (i.e., working up to 1 g at-a-time, two-to-three
times a day) could and—together with the implications gathered from this report
along with the extent of information from others [74]—even should be considered
as potent preventive and therapeutic medicine against COVID-19 and
inflammatory disease, in general. Given the marked deficiency in available NA
from diet, these what many misinterpret to be “mega” doses more likely actually
more appropriately represent sufficient doses.

As the flush response is indeed safe and should be sought when needed for its
anti-inflammatory properties, it is important to administer (via oral ingestion)
exclusively the immediate-release form of NA, preferably as a tablet/pill or
straight powder. If the immediate-release NA happens to be provided in a
capsule, then it would be advantageous—as to not impede the flush response—

for the capsule material to not contain any gelatin-like components like aloe vera
and to dispense the powder to take with water. Similarly, administration of
immediate-release NA should be accompanied with abstinence from compounds
that may inhibit the flush response, such as aspirin, inositol, and potentially the
pectin in apples, and that may contradict the therapeutic and/or protective effects
of NA (notably N-acetyl cysteine, glutathione, and 5-hydroxytryptophan)."

Beverage you will appreciate this article the above citation is from this article entitled "Sufficient niacin supply: the missing puzzle piece to COVID-19, and beyond?" since you noted below  how you think it might helped you recover from COVID-19 quickly.

1 hour ago, Beverage said:

I took 1500mg after I got covid, and recovered very quickly

https://osf.io/uec3r/

This reseasrch article explains how that might be so!

From the above link you can see the abstract or view the whole citation (which is well worth your time IMHO) and what I have cited above about Niacin's aka Nicotinic Acid safety section.

Trents "Invite" the flush and I think you will be happy with your results......as long as you know it's coming....it is very soothing IMO.

The "Niacin Flush" has also been shown to help increazse restful sleep!

Here is an article about it....

https://lucidconsciousness.blogspot.com/2009/01/niacin-and-pdg2-sleep-substance.html

I hope this is helpful but it is not medical advice.

As always 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the Grace of God,

[Rogol72]

9 hours ago, Beverage said:

I've had fantastic results with the flush form of niacin, increased energy, strength, overall health, skin younger, feel younger, better sleep, and sinuses much more open, asthma gone. Quercetin didn't do anything for me.

Great result indeed! So is it safe to say that Niacin is a good remedy for Sinusitis in general?

[Posterboy]

On 9/2/2022 at 9:40 PM, trents said:

I'm not really concerned about its effect on cholesterol. My concern is which one will have the most postive effect for lowering  histamine levels, if either.

Trents,

Niacin aka Nicotinic acid is the form that will help lower you elevated histamine levels.

The Nicotinic Acid form of Niacin is a flood gate mediator of built up PGD2 a primary regulator of Histamine in the body.

Once PGD2 builds up......your histamine release becomes bound up in your membranes defeating your natural response to allergens.  High histamine levels can be toxic and withouot Niacin to release the PGD2 the Histamine builds up to toxic levels.

Taking Nicotinic acid allows you to flush out the PGD2 thus releasing all your built up histamines in your membranes IE your Skin and Lung tissue.

It is why Beverage(s) Ashtma got better when she took the flushing Niacin and why blocking for this Niacin flush is counter productive and leads to histamine issues.  And why high Histamine levels leads to Histamine Intoleracne and how taking Nicotinic Acid can help it.  It is what causes use to itch, scatch and cough from too much Histamine built up in our tissues regulated by PGD2 which is released when we take enough Niacin to flush it out via the flushing effect triggered by high doses of Niacin.

Here is some research on it.

Entitled "Niacin-induced “Flush” Involves Release of Prostaglandin D2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model"

https://jpet.aspetjournals.org/content/327/3/665

They have known for about 10 years now......that blocking for the Flushing Effect of Niacin is not good for your heart health.....and why Flush Free Niacin is not a good form to take.....and can cause poor health outcomes because we are trying to suppress and a natural and healthy response to Niacin.

This article explains it well....

Entitled  "New study cautions use of drugs to block 'niacin flush'"

https://medicalxpress.com/news/2012-04-cautions-drugs-block-niacin-flush.html

see also this study that conclusives proves in IMO that Niacin controlls PGD2 levels in the body.

Entitled  "Release of markedly increased quantities of prostaglandin D2 in humans following the administration of nicotinic acid aka Niacin"

https://www.sciencedirect.com/science/article/abs/pii/0090698089900889

This also explains why Niacin can help skin issues like DH, Ezcema and Psorias etc.......this release of PGD2 by Niacin can also help the "painful, itching" of DH because Niacin releases PDG2 from under the skin the triggering mechanism of this itching and pain in DH patients.

Where they note quoting

"The fact that markedly increased quantities of PGD2 are released suggests that PGD2 is the mediator of niacin-induced vasodilation in humans."

The 100mg you bought is a good moderate amount.....enough to create flushing but low enough not to interfere (with your INR Rate).....if indeed it can be proven the Flushing form causes an elevated INR........which has only been proven for the Non-Flushing form....

I hope this is helpful but not medical advice.

As always 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the grace of God,

[Posterboy]

Trents,

I also wanted to say watch out for Glucosamine Chrondrotion.......it might evelate your INR if you haven't heard about this affect before......a common supplement used for Arthritis.

See this reseasrch about it....

Entitled "Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database"

https://pubmed.ncbi.nlm.nih.gov/18363538/

Again I hope this is helpful but it is not medical advice.

Posterboy,

[trents]

Thanks for the warning, PB but I don't take that one. 

But I do have a question for you with regard to Niacin and the flush.

I've been reading that the flush is evidence that the Niacin is doing what it is supposed to do. But I also read that the flush eventually goes away as you continue niacin therapy over time. Does that mean it's no longer being effective?

I also wonder about taking it with food or between meals. I've been experimenting with it as I got some quick release nicotinic acid recently. I started with a 100 mg dose the first day immediately after eating breakfast and there was no flush. Same with 200 mg. On day three I took 300 mg on an empty stomach and got a strong flush within 20 minutes. This morning I took 300mg immediately after breakfast and no flush. So, I'm guessing I would need to bump up the dosage considerably if I take it with meals in order to get a flush. Which is better, higher dosage with meals of lower dosage on empty stomach?

[Posterboy]

Beverage and Trents Et Al,

@Beverage I think you will like this article....

Sometimes you can't get all your resources/resources in one post.

Beverage this article explains how PGD2 can cause Asthma attacks that taking the Nicotinic Acid helped by releasing PGD2 from your lung tissue...

Entitled "Prostaglandin D₂ and T(H)2 inflammation in the pathogenesis of bronchial asthma"

https://pubmed.ncbi.nlm.nih.gov/21437156/

And for the role of PGD2 roles in a Mast Cell attack this is a good article overall......which has some key information....

Entitled "Mast cell mediators: Prostaglandin D2 (PGD2)" from the website Mast Attack

https://www.mastattack.org/2015/04/mast-cell-mediators-prostaglandin-d2-pgd2/

And why our focus on Histamine Intolerance is a valid one.....it is a misguided one...

quoting from the above website on Mast Cells...

"PGD2 is a strong bronchoconstrictor. It is 10.2x more potent in this capacity than histamine and 3.5x more potent than PGF2a. It has been associated with inflammatory and atopic conditions for many years. Presence of allergen activates PGD2 production in sensitized people. In asthmatics, bronchial samples can achieve over 150x the level of PGD2 compared to controls. Elevated PGD2 has been associated with chronic coughing."

And why taking the flushing Niacin form as Nicotinic Acid can be helpful for Asthma because it is 10x more powerful in causing a reaction to an environmental stimuli...

And once the PGD2 is flushed out.....the cough reflux is calmed being diagnosed as Asthma when it was a build up of PGD2 in our membranes but really is a sign of low cellular Niacin levels in the body....

You can only understand this by getting "Deep in the Weeds" and studying all the relevant studies about the topic.

Again I hope this is helpful but it is not medical advice.

Posterboy,

 

[Posterboy]

11 minutes ago, trents said:

Thanks for the warning, PB but I don't take that one. 

But I do have a question for you with regard to Niacin and the flush.

I've been reading that the flush is evidence that the Niacin is doing what it is supposed to do. But I also read that the flush eventually goes away as you continue niacin therapy over time. Does that mean it's no longer being effective?

I also wonder about taking it with food or between meals. I've been experimenting with it as I got some quick release nicotinic acid recently. I started with a 100 mg dose the first day immediately after eating breakfast and there was no flush. Same with 200 mg. On day three I took 300 mg on an empty stomach and got a strong flush within 20 minutes. This morning I took 300mg immediately after breakfast and no flush. So, I'm guessing I would need to bump up the dosage considerably if I take it with meals in order to get a flush. Which is better, higher dosage with meals of lower dosage on empty stomach?

Trents,

"So, I'm guessing I would need to bump up the dosage considerably if I take it with meals in order to get a flush. Which is better, higher dosage with meals of lower dosage on empty stomach?"

For Niacin......to invite the Flush an emty stomach is better.....you are experiencing what is known as titration....

It is common to take it in 100mg steps up till you can tolerate the higher doses.....usually up to 500mg size on a empty stomach.

It will ramp down over a couple weeks until all the PGD2 is flushed out of your skin and lung tissue and membranes etc.....this is when the "magic happens" and your itchy, scratchy goes away because you have removed the powerful PGD2 trigger that is triggering your mast cell reactions.

Food will compete for absorption so it naturally mutes the flushing effect and how most peopel will take it untill they know what the Niacin flush is....

But if lower dose are not flushing you can step up to the higher doses more easily....

Here is a nice articel about it...

https://getwellstaywellathome.com/blog/2015/06/seasonal-allergies-and-the-niacin-flush/

I only take Niacin intermediately now (ever so often) because I had taken Niacinamide for quite some time....

Niacin can still help you (longer term)......it is just that the PGD2 molecule has now been depleted from your skin and lungs etc.......and why the reduced flushing.....

Niacin will continue to help you.......Niacin will cause an intense and regular burping if you don't already burp (or only burp from carbonization in the first 20 minutes after eating)........but burping 2 hours after you eat.....and even between meals....and you will find your lingering heartburn issues will "magically disaappear" it inot magic.......your stomach acid is now strong enough to digest (again finally) the foods you are eating!

It is a sign you are building stomach acid again....it takes a minimum of 3 months to fill up your liver with enough reserves for your body to begin functioning properly again.....

Prousky wrote about it......and its (Niacin's) role in the production of stomach acid......which Celiacs' are commonly low in....

http://orthomolecular.org/library/jom/2001/pdf/2001-v16n04-p225.pdf

I summarized his work in this blog post....

A 3 month baseline should be establised by taken it frequently for 3 months.

Frequent small doses is much better than 1 larger dose.

3x 100 mg doses is 40 percent better than 1x day 250 mg dose etc....

I summarized most of this here in my Posterboy blog posts of why you would want to take Niacin and/or Niacinamide in the first place for GI problems.

You can read it so I don't have to type everything out again and again etc...

If you still have any additional questions after reading it.....I will be glad to try and answer them!

Note: When you get low in Niacin or Niacinamide......it is Capstone deficiency......you are also low in your other B-Vitamins as well......but give Niacin/Niacinamide a 2 or 3 month start and I don't think you will regret it.

At this point you can add back in your MultiVitamin and/or B-Complex.

This way you will know it is the Niacin that is helping and not some other B-Complex that is also helping you.

IF you have been taking a Multiviamin already......you have rebuilt some of your reserves already and why you might not be flushing as much as someone who has not been already taking a Multivitamin etc.

I  hope this is helpful but it is not medical advice.

Posterboy,