magnesium deficiency Magnesium Deficiency and High Histamine Levels could it be causing your Allergies?

[Rogol72]

 

I thought it worth sharing this regarding the histamine and histadelia conversation ...

https://www.natures-source.com/blogs/news/histadelia-a-primer-on-histamine-folate-and-methylation/

"Beware of excess folate in your diet, One thing to caution readers about concerns the role of folate - folic acid, in all of this chemistry. Nothing raises blood histamine surer, faster and higher than excess dietary folate. If a knowledgeable practitioner believes you are tending to histadelia the first thing they should recommend is that you immediately stop taking any multivitamins containing folic acid. In extreme cases, a physician may prescribe the prescription anti-folate Dilantin until things stabilize.

An interesting and illustrative anecdote on folate and histamine was observed by the late Carl Pfeiffer, M.D. who was a leader in this field. He reported that he and his colleagues were puzzled that so many histadelic patients relapsed in the summer months. Eventually, the reason was found to lie in the increase of dietary folate that was found in green , leafy salad vegetables that people ate throughout the summer months.

When this was corrected, his patients improved, but a new name was born "Summer Salad Syndrome". No kidding."

[Posterboy]

22 hours ago, Posterboy said:

Niacin can still help you (longer term)......it is just that the PGD2 molecule has now been depleted from your skin and lungs etc.......and why the reduced flushing.....

Trents, Beverage, Rogol, Knitty Kitty et Al,

Since we were talking about PGD2 and Niacin role in regulating Prostaglandins I  thought this research would be helpful.

PGD2 is short for Prostaglandins for the super researchers on this site and want to do the research for themselves.

Entitled "Niacin ameliorates ulcerative colitis via prostaglandin D 2-mediated D prostanoid receptor 1 activation"

https://pubmed.ncbi.nlm.nih.gov/28341703/

I probably should start a new thread about Niacin and Prostaglandins or PGD2 but I haven't got around to it yet.

Either way it establishes how Niacin regulates Prostaglandin release in the body thus downregulating inflammation/stress in the body leading to a remission of GI symptoms by controlling/ameliorating leaky gut issues.

quoting the conlusion/syposis of their abstract

"Niacin treatment improved vascular permeability (IE Leaky Gut), reduced apoptotic epithelial cells, promoted epithelial cell update, and suppressed pro-inflammatory gene expression of macrophages. Moreover, treatment with niacin-containing retention enema effectively promoted UC clinical remission and mucosal healing in patients with moderately active disease. Therefore, niacin displayed multiple beneficial effects on DSS/TNBS-induced colitis in mice by activation of PGD2/DP1 axis. The potential efficacy of niacin in management of IBD warrants further investigation."

Niacin role(s) in promoting GI health has been found in other GI diseases....

See this research https://www.sciencedaily.com/releases/2014/01/140116113510.htm

where they say quoting

"We think mega-doses of niacin may be useful in the treatment and/or prevention of ulcerative colitis, Crohn's disease, and colorectal cancer"......

Why wouldn't we think it would help Celiac disease as well?

This research brings back around "Full Circle" you might say....

Wheref find Tryptophan......a precursor to Niacin in the body is thought to be behind the Pathogenesis of IBS etc.

See this research entitled "Tryptophan: ‘essential’ for the pathogenesis of irritable bowel syndrome?"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266036/

This is notebable because they talk about IDO in this article and its role in Histamine levels in the body.....and how this is all interrelated...

It comes back to the fact how the kynurenine pathway (or synthesis of Niacin in the body via Tryptopahn is broken)......leadin to the pathogenesis of GI diseases...

We see this when we find (as one might predict) that Tryptophan can improve/heal Villi in Celiac's.....becasue know this Kyneurine Pathway has been restored in the body...

See this very recent reseasrch about this that bears this out entitled "Trytophan found in Turkey can accelerate intestinaal healing in people with Celiac disease".

https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx

I summarized alot of this information in this Posterboy blog about how B-Vitamin deficiencie(s) can trigger alot of our GI problems....if anybody wants to read it...

Alot of the deep "in the weeds" research is in the appendix.....study/research it to your hearts content till you understand it for yourself....

Again, I hope this is helpful but it is not medical advice.

2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the grace of God,

[Scott Adams]

I know that this isn't directly related, more so with regard to brain fog as a symptom of celiac disease, but since we're often "pushing" vitamins/supplements on Celiac.com there is a lot of science happening now to support the multivitamin/minerals approach for everyone, and not just celiacs:

Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12767

Quote

Results

A total of 2262 participants were enrolled (mean age = 73y; 60% women; 89% non-Hispanic White), and 92% completed the baseline and at least one annual assessment. Cocoa extract had no effect on global cognition (mean z-score = 0.03, 95% CI: -0.02 to 0.08; P = .28). Daily MVM supplementation, relative to placebo, resulted in a statistically significant benefit on global cognition (mean z = 0.07, 95% CI 0.02 to 0.12; P = .007), and this effect was most pronounced in participants with a history of cardiovascular disease (no history: 0.06, 95% CI 0.01 to 0.11; history: 0.14, 95% CI -0.02 to 0.31; interaction, nominal P = .01). Multivitamin-mineral benefits were also observed for memory and executive function. The cocoa extract by MVM group interaction was not significant for any of the cognitive composites.

Summary:

https://www.medscape.com/viewarticle/980785

[Rogol72]

On 9/16/2022 at 7:27 PM, Scott Adams said:

I know that this isn't directly related, more so with regard to brain fog as a symptom of celiac disease, but since we're often "pushing" vitamins/supplements on Celiac.com there is a lot of science happening now to support the multivitamin/minerals approach for everyone, and not just celiacs:

Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12767

Summary:

https://www.medscape.com/viewarticle/980785

I'm wondering if there is a genetic test that can identify how well a person metabolises vitamins and minerals? You could then tailor your supplementation to those needs to hit the sweet spot without over or under doing it and saving some money at the same time! For example, I can maintain a healthy Vitamin D level at the upper RDA with a relatively low dose of 1000iu, while others need to take 10,000iu for months before it budges! And I go through magnesium like nothing on earth.

[knitty kitty]

That would be great! 

Here's a place to learn more about how thiamine deficiency can run in families....

https://www.hormonesmatter.com/familial-beriberi-discovering-lifelong-genetic-thiamine-deficiency/

And...

https://www.hormonesmatter.com/genetic-thiamine-deficiency-ravaged-my-family/

And...

https://www.hormonesmatter.com/tag/thiamine-deficiency/

[Posterboy]

13 hours ago, Rogol72 said:

I'm wondering if there is a genetic test that can identify how well a person metabolises vitamins and minerals? You could then tailor your supplementation to those needs to hit the sweet spot without over or under doing it and saving some money at the same time! For example, I can maintain a healthy Vitamin D level at the upper RDA with a relatively low dose of 1000iu, while others need to take 10,000iu for months before it budges! And I go through magnesium like nothing on earth.

 Rogol72,

It might not be as straightforward as it first seems....

Here is a nice article showing how many times lab tests are not as accurate as you might think....

https://novoslabs.com/frequently-asked-questions/testing/is-blood-testing-necessary/#:~:text=For example%2C a DNA test looks at one,looked at%2C or are not even known (yet).

And sometimes......they simply get it wrong.

the MTHFR gene variant that sometimes  is discussed on this forum really is just another Vitamin defiency.

Without the proper Co-Factors......(INcureable) conditions like Wernikces Encephalopathy aka WE is really just  another Vitamin or Mineral deficiency.

See this reseasrch where Thiamine can not and will not help Wernickes Encephalopathy without some Magnesium etc....

Entitled "Thiamine (deficiency) refractory Wernickes encephalopathy reversed with magnesium therapy"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093844/

Or this one described as a gene defect when it is really being low in Thiamine instead...

Entitled "Pancytopenia in an adult patient with thiamine-responsive megaloblastic anaemia"

https://casereports.bmj.com/content/2018/bcr-2018-225035

I could go on....and on....but you get the idea...

I hope this is helpful but it is not medical advice.

Posterboy,

[Posterboy]

On 8/18/2022 at 5:45 PM, trents said:

I seem to always get congested at night while sleeping and this causes terrific headaches/migraines. I'm also attempting to eat lower histamine but that as a singular approach is not going to do the job.

 

On 8/30/2022 at 7:09 PM, trents said:

Actually, the changes I have made so far with upping magnesium, upping zyrtec from 10-15 mg daily and taking the DAO supplement seems to be working for the headaches.

Trents,

I have been busy lately with other things......but I wanted to try and address your issue(s) with Migraines.

I wil try and post this also in the thread I started on B-Vitamins etc....

But if you continue to have Headaches/Migraines you should try some Riboflavin aka Vitamin B-2 as well...

Here is some reseasrch that would/could be helpful to you!

Entitled "Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine" including Riboflavin...

https://pubmed.ncbi.nlm.nih.gov/34959985/

Here is a list quoting from the research on Migraines that might also help your migraines...

The nutrients that can be considered to supplement the diet to prevent and/or ameliorate migraine are riboflavin (B2), thiamine (Niacin), magnesium ions, niacin (B3), carnitine, coenzyme Q10, melatonin, lipoic acid, pyridoxine (B6), folate (B9), and cobalamin (B12)."

This research also summarizes well the role B-Vitamins (and/or a B-Complex) plays in the health of the Central Nervous System (CNS)...

Summarized in this article entitled "B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930825/

I hope this is helpful but it is  not medical advice.

Posterboy,

[Posterboy]

To All,

I am thinking specifically of Wheatwacked and Knitty Kitty and Trents but it can help anyone who reads it.

I thought about making this a separate topic (just because it would be easier to find (as a reference article) and still might) but since this topic is already started it can go in here as well!

It is a referernce article I just came across about how important Magnesium is for general overall health and just wanted to add it here (for reference) for any body who want to do more research on Magnesium etc.

Entitled "Magnesium: The Forgotten Electrolyte—A Review on Hypomagnesemia"

https://www.mdpi.com/2076-3271/7/4/56/htm

I hope this is helpful but it not medical advice.

Posterboy,

[Musickel]

Wow, this article is very helpful! I have been a celiac for over 30 years. I have realized I had low stomach acid ever since I had malabsorption seven years ago, (I probably had it way before that too, because I remember feeling so full after eating something for a very long period of time ) when everything w my health fell apart. I had depression, anxiety, terrible brain fog and was dropping weight and didn’t even know I had malabsorption until about six months later… and I healed it with the SCD diet, pretty much everything, except for the insomnia . and I’ve had to take HCL BEFORE MEALS AND DIGESTIVE ENZYMES EVER SINCE THIS CAN ALSO BE VERY EXPENSIVE !! And only to find out several years later when I had a genetic test, and then a genetic analysis by someone else, that histamines could be causing my insomnia!!!  so I’ve been on a low histamine diet for about five months now and I’m so sick of it. I just want to eat normal again! Reading this about niacin to help stomach acid I mean I already take a B complex vitamin daily by seeking health, but obviously, there’s only a small amount of niacin in it. I spent so much money on doctors over the last seven years to try to get sleep. And who can afford functional medicine doctors anymore ! Part of the insomnia was histamines, but the other part I believe was / is blood sugar issues. Which I’ve been taking alpha lipoic acid for and it’s been really helping. Anyhow, I’m very glad to read this and glad to be a part of this group and I know this was a post from last year but I’m posting anyway. 🌹thx so much gonna try it!! 

[jtalbot1021]

This makes me wonder how LONG I've been magnesium deficient. A lot of these things have plaiged me for years 

[Scott Adams]

I recently ran out of my daily magnesium supplement and was lazy in getting another bottle for a few days, only to find that my leg cramps and charley horses came back. I am surprised how soon that happened.

[jtalbot1021]

On 2/21/2023 at 11:28 PM, Scott Adams said:

I recently ran out of my daily magnesium supplement and was lazy in getting another bottle for a few days, only to find that my leg cramps and charley horses came back. I am surprised how soon that happened.

Me too! It was within a day.