Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Genetic tests

asaT
 Share
Go to solution Solved by Scott Adams,

Recommended Posts

asaT Rookie
asaT
Posted

I was just diagnosed a few weeks ago and now some family members are being tested, just wanted some input on that.

I have the HLA-DQ2.5 gene haplotype according to 23&me and so does my brother. He has yet to go in and get antibody testing. He has 3 boys. One (12y.o at the time)has been diagnosed with UC and had negative antibody titer when that was done (but no s.i. biopsy). The other one (10 y.o at time) had upper gi scope for swallowing problems and had a s.i. biopsy which was negative for celiacs, it seemed to be an esophageal problem. No known problems with the third youngest one. He wants to do genetic testing on them before doing anything else. His insurance is horrible and won't pay for anything so he is looking at the tests you can order online. 

My question is, is the 23 and me test sufficient? the other one we were looking at is this: https://rxhometest.com/product/search/celiac

They are both $129, but the 23&me obviously has a lot more extra info other than the celiacs. Which one should they do? Or any other recomnendations?

Thanks!

Asa

Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


asaT Rookie
asaT
  • Author
Posted

Also my mom is having antibody testing done as she has many symptoms, BUT she tests negative on the 23&me test for a celiacs variant. So i'm not sure if 23 and me picks up all the genes? 

Link to comment
Share on other sites
  • Solution
Scott Adams Grand Master
Scott Adams
  • Solution
Posted

23 and me should work for most of the basic genetic markers (I'm not sure about the other company, but it would likely be fine as well).

He may also want to try this for a blood screening on his family: https://www.imaware.health/

Interestingly, my daughter's main symptom was the feeling that there was always food stuck in her throat/esophagus, when there wasn't. She had elevated enzymes but was just below the cut off for celiac disease, but went gluten-free because of the throat symptoms, which went a way after she went gluten-free.

 

Link to comment
Share on other sites
asaT Rookie
asaT
  • Author
Posted
On 10/21/2022 at 10:36 AM, asaT said:

I was just diagnosed a few weeks ago and now some family members are being tested, just wanted some input on that.

I have the HLA-DQ2.5 gene haplotype according to 23&me and so does my brother. He has yet to go in and get antibody testing. He has 3 boys. One (12y.o at the time)has been diagnosed with UC and had negative antibody titer when that was done (but no s.i. biopsy). The other one (10 y.o at time) had upper gi scope for swallowing problems and had a s.i. biopsy which was negative for celiacs, it seemed to be an esophageal problem. No known problems with the third youngest one. He wants to do genetic testing on them before doing anything else. His insurance is horrible and won't pay for anything so he is looking at the tests you can order online. 

My question is, is the 23 and me test sufficient? the other one we were looking at is this: https://rxhometest.com/product/search/celiac

They are both $129, but the 23&me obviously has a lot more extra info other than the celiacs. Which one should they do? Or any other recomnendations?

Thanks!

Asa

Thanks for the info Scott. Hopefully we will get some answers soon. The one with the swallowing problems had a biopsy which they said ruled out celiacs, but only one sample was taken and no blood test was done that i am aware of, but its possible he just didn't tell me. I think he would have though because i have been a pain in the ass about it. now i have to tell him that one sample is not a good test. i think i'll wait til the genetic tests come back though. if he has the gene then i'll mention it, if not, then i can stop talking about it!

Link to comment
Share on other sites
Scott Adams Grand Master
Scott Adams
Posted

I think it would be worth asking if they did a blood test, and if so, try to get the results and share them here. Either way, note that there is a condition called non-celiac gluten sensitivity which around 10x more people have than celiac disease, and unfortunately they have not yet developed a test for it. It may make sense to just try out the gluten-free diet after all celiac testing is done, just to see if symptoms improve. Note that a gene test won't be affected either way when someone is on a gluten-free diet, but celiac disease tests will be affected (patients should continue eating gluten until all celiac testing is finished).

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      125,799
    • Most Online (within 30 mins)
      7,748
    K Binnicker
    Newest Member
    K Binnicker
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.8k
    • Total Posts
      68.9k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Scott Adams
      Is McDonald's Safe for Gluten-Free Orders?

      By Scott Adams · Posted

      Hydrolyzed wheat is wheat protein that has been broken down into smaller components through a chemical or enzymatic process called hydrolysis. This ingredient can be found in various products, including cosmetics, personal care items, and some food products. For people with celiac disease, hydrolyzed wheat is generally not safe to consume because it still contains gluten proteins, even in its broken-down form. Though hydrolysis reduces the size of these proteins, it doesn’t fully remove the components that trigger an autoimmune response in people with celiac disease. In food products, hydrolyzed wheat protein still poses a risk and should be avoided. With regard to the McDonald's French fries, the total amount of hydrolyzed wheat in the flavoring is small, and the amount that ends up in an order of fries is even smaller, and likely below 20ppm. McDonald’s states that the fries are gluten-free by ingredient and free from cross-contact with gluten-containing foods in their dedicated fryers. Third-party tests and statements by McDonald's confirm gluten levels are below the FDA threshold for gluten-free labeling (20 parts per million or less). So, while McDonald’s USA fries are widely accepted as gluten-free based on testing and labeling, some people with celiac disease still approach them cautiously due to the past concerns and individual sensitivities.
    • trents
      Is McDonald's Safe for Gluten-Free Orders?

      By trents · Posted

      Here is an excerpt from this article: https://pmc.ncbi.nlm.nih.gov/articles/PMC82695:   Studies have shown that various peptidases of fungal, plant, animal, or bacterial origin are able to hydrolyze gluten into harmless peptides. According to SDS‐PAGE pattern, proteolytic enzymes hydrolyze gliadins (Heredia‐Sandoval et al., 2016; Scherf et al., 2018; Socha et al., 2019; Wei et al., 2018, 2020). Bacterial peptidase (Krishnareddy & Green, 2017), fungal peptidase (Koning et al., 2005), and prolyl endopeptidases (PEPs) (Amador et al., 2019; Janssen et al., 2015; Kerpes et al., 2016; Mamo & Assefa, 2018) thoroughly degrade gliadin fractions to decrease gluten concentration and influence celiac disease. Aspergillus niger derived PEP (AN‐PEP) were assessed in clinical cases for their impact on modifying immune responses to gluten in celiac patients (Lähdeaho et al., 2014). Guerdrum and Bamforth (2012) reported that PEP addition in brewing technology decreased the prolamin and all of the identified immunopathogenic gluten epitopes in beer production (Akeroyd et al., 2016). On the contrary, many of the recent investigations which employed enzyme‐linked immunosorbent assay (ELISA), mass spectrometry, and Western blot analysis reported that PEP did not thoroughly destroy the whole gluten proteins (Allred et al., 2017; Colgrave et al., 2017; Fiedler et al., 2018; Panda et al., 2015), which indicates that beers treated with PEP are not safe for celiac disease patients. Anecdotally, this excerpt supports what we hear from the celiac community on this forum with regard to "gluten free" hydrolyzed wheat products and that is that some still react to them while many don't.
    • Scott Adams
      Anybody else have a similar experience...theories welcome as its something which i dont really understand.....

      By Scott Adams · Posted

      There aren't good studies that have been done on celiac disease remission, and I'm going from a distant memory of an older post here, but the longest remission that Dr. Stefano Guandalini from the University of Chicago Celiac Disease Center has witnessed was ~10 years, then the symptoms of celiac disease and the damage came back. The real issue though, is that you still could increase your risk of various related diseases and disorders by eating gluten, but again, celiac disease remission has not been studies enough to know what health risks you might face.
    • trents
      Is McDonald's Safe for Gluten-Free Orders?

      By trents · Posted

      Scott, could you elaborate on hydrolyzed wheat? Does that remove or deactivate the gluten protein?
    • Scott Adams
      Is McDonald's Safe for Gluten-Free Orders?

      By Scott Adams · Posted

      McDonald's has a gluten-free bun, are you in Europe? They don't have that in the USA but I hope they are coming here soon. In the USA the fries are not considered gluten-free, even if they are made in a dedicated fryer, but many celiacs, including myself, have been eating them for years without issues. In Europe they don't have the same hydrolyzed wheat as an ingredient in their beef flavoring, like they do here in the USA. This is a controversial topic that I wanted to mention with you, but you can check the ingredients on the McDonald's website, as they can vary from country to country.
×
×
  • Create New...