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Digestive Enzyme side effects


MattGreen

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MattGreen Newbie

Years ago i was diagnosed with celiacs, i cut out gluten for a while and now it seems its just a celiac intolerance, comes up barely on the blood test.  With my digestive problems came a bunch of food intolerance's i never had though, my digestion has never really gotten back to normal, i assumed i have some form of 'leaky gut' or along those lines.  Last year i started taking plant/fungal based Digestive Enzymes and found they helped me greatly, way more than the previously prescribed animal based enzymes i had tried.  But it didn't take long before i started feeling side effects, the most notable one being breathing difficulties, and slightly increased heart rate, making it hard to sleep and exercising uncomfortable.  It starts becoming very noticeable after i take them with every meal over the course of a day or 2.  basically my digestion starts feeling great, i can eat more and more types of foods, energy goes up, but then the side effects kick in, so im basically trying to figure out how to manage taking these digestive enzymes.  I've tried 3 brands, one from 'prairie naturals' called enzyme force, 2 or 3 different ones from 'enzymedica', and another from 'natural factors' called multi-enzyme.  They all generally start giving the same side effects.  Has anyone else had the same issue ? Or is there a brand someone else would recommend? 

This is probably a very isolated issue but i feel if i could just find one that didn't start giving me side effects my digestion could start feeling normal again.

 


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knitty kitty Grand Master

Welcome to the forum!

Could you give us a better idea of what you are eating? 

Are you eating out at restaurants and possibly getting cross contaminated? 

Is your diet heavy on carbohydrates?

Have you been checked for vitamin and mineral deficiencies?  Celiac Disease damages the small intestine where vitamins and minerals are absorbed.  

"...side effects, the most notable one being breathing difficulties, and slightly increased heart rate, making it hard to sleep and exercising uncomfortable."

These are early symptoms of thiamine insufficiency.  Thiamine is needed to make and secrete digestive enzymes.  Thiamine is needed to help red blood cells carry oxygen to the cells, especially during exercise.  "Sailors' asthma" is a symptom of thiamine insufficiency.  Tachycardia and insomnia are also symptoms of thiamine insufficiency.  

The more carbohydrates you eat, the more Thiamine you need to convert them to energy.  

Discuss with your doctor the benefits of supplementing with Thiamine Vitamin B 1 and the rest of the B vitamins and magnesium.  Talk to a nutritionist to ensure you are getting a nutrient dense diet.

 

trents Grand Master

Welcome to the forum, Matt!

Are you back to eating significant amounts of gluten?

You say you "it comes up barely on the blood test". Which blood test do you refer to? Can you be more specific? I assume you are referring to a celiac antibody blood test but there is not just one. Do you have access to your medical record from recent testing and can you post the test result along with the reference range?

But the fact that you are still getting a weak positive means you are still producing celiac antibodies so I do not think the lower scores indicate you have converted somehow from having celiac disease to merely being gluten sensitive (aka, NCGS for Non Celiac Gluten Sensitivity, a better term than your "gluten intolerant" which is an umbrella term for all gluten-related disorders). Some celiacs report that they have gone into "remission" but it usually doesn't last.

Is there a common ingredient in the various "digestive enzyme" products you are taking that might cause the side effects you describe?

I' afraid that you are deceiving yourself into thinking you no longer have celiac disease and damage to your body is still happening, even though the outward symptoms are not what they used to be. And that brings up a good question. In the beginning when you were diagnosed with celiac disease, what were your symptoms? What led you to get tested for celiac disease? Are those symptoms, in fact, gone now?

Scott Adams Grand Master

Welcome to the forum!

What is your goal with the enzymes? Do you eat at restaurants and at other non-gluten-free homes? Is your goal to deal with the effects of possible cross-contamination with gluten? If so, you would need an enzyme designed for this, for example GliadinX, which is one of our sponsors. General enzymes may be good for lots of different things, but AN-PEP enzymes work specifically to break down gliadin in the stomach (small amounts only).

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    • trents
      Welcome to the forum, @ABP! We can't comment on the test numbers you give as you didn't include the range for negative. Different labs use different units and different ranges. There are no industry standards for this so we need more information. If your daughter doesn't have celiac disease she still could have NCGS (Non Celiac Gluten Sensitivity) which some experts believe can be a precursor to celiac disease and is 10x more common than celiac disease. However, there is no test for it yet but it does share many of the same symptoms with celiac disease. Both require complete abstinence from gluten.  It is seldom the case during testing where all tests are positive, even for those who do have celiac disease. This is no different than when diagnosing other medical conditions and that is why it is typical to run numbers of tests that come at things from different angles when seeking to arrive at a diagnosis. It seems like you are at the point, since you have had both blood antibody testing and endoscopy/biopsy done, that you need to trial the gluten free diet. If her symptoms improve then you know all you need to know, whatever you label you want to give it. But given that apparently at least one celiac antibody blood test is positive and she has classic celiac symptoms such as slow growth, constipation and bloating, my money would be on celiac disease as opposed to NCGS.
    • ABP
      My nine-year-old daughter has suffered with severe constipation and bloating for years as well as frequent mouth sores, and keratosis Polaris on her arms. She also has recently decreased on her growth curve her % going down gradually.  After seeing a gastroenterologist, her IgG GLIADIN (DEAMIDATED) AB (IGG) was 22.4 while her IGA was normal. Her TISSUE TRANSGLUTAMINASE AB, IGA was 11.9.  Most recently her genetic test for celiac was positive.  After an endoscopy her tissue showed inflammation of the tissue as well as , increased intraepithelial lymphocytes (IELs) but there was no blunting of the change in the villi.    It seems that every result that we get one out of two things positive rather than all leading to an inconclusive diagnosis. While we do have another appointment with the doctor to go over the results. I'm curious based on this information what others think.    I would hate to have her eliminate gluten if not necessary- but also don't want to not remove if it is necessary.    Signed Confused and Concerned Mama
    • Scott Adams
      I guess using "GF" instead of "PL" would have been too easy! 😉
    • trents
      I was wrong, however, about there being no particular health concerns associated with high total IGA: https://www.inspire.com/resources/chronic-disease/understanding-high-iga-levels-causes-impacts/ So maybe the physician's "borderline" remark is relevant to that.
    • trents
      Sometimes that is the case but what is curious to me is the remark by your physician about being "borderline". I assume he was referring to the total IGA score but it just seems like an irrelevant remark when it is on the high side rather than being deficient.
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