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Digestive Enzyme side effects


MattGreen

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MattGreen Newbie

Years ago i was diagnosed with celiacs, i cut out gluten for a while and now it seems its just a celiac intolerance, comes up barely on the blood test.  With my digestive problems came a bunch of food intolerance's i never had though, my digestion has never really gotten back to normal, i assumed i have some form of 'leaky gut' or along those lines.  Last year i started taking plant/fungal based Digestive Enzymes and found they helped me greatly, way more than the previously prescribed animal based enzymes i had tried.  But it didn't take long before i started feeling side effects, the most notable one being breathing difficulties, and slightly increased heart rate, making it hard to sleep and exercising uncomfortable.  It starts becoming very noticeable after i take them with every meal over the course of a day or 2.  basically my digestion starts feeling great, i can eat more and more types of foods, energy goes up, but then the side effects kick in, so im basically trying to figure out how to manage taking these digestive enzymes.  I've tried 3 brands, one from 'prairie naturals' called enzyme force, 2 or 3 different ones from 'enzymedica', and another from 'natural factors' called multi-enzyme.  They all generally start giving the same side effects.  Has anyone else had the same issue ? Or is there a brand someone else would recommend? 

This is probably a very isolated issue but i feel if i could just find one that didn't start giving me side effects my digestion could start feeling normal again.

 


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knitty kitty Grand Master

Welcome to the forum!

Could you give us a better idea of what you are eating? 

Are you eating out at restaurants and possibly getting cross contaminated? 

Is your diet heavy on carbohydrates?

Have you been checked for vitamin and mineral deficiencies?  Celiac Disease damages the small intestine where vitamins and minerals are absorbed.  

"...side effects, the most notable one being breathing difficulties, and slightly increased heart rate, making it hard to sleep and exercising uncomfortable."

These are early symptoms of thiamine insufficiency.  Thiamine is needed to make and secrete digestive enzymes.  Thiamine is needed to help red blood cells carry oxygen to the cells, especially during exercise.  "Sailors' asthma" is a symptom of thiamine insufficiency.  Tachycardia and insomnia are also symptoms of thiamine insufficiency.  

The more carbohydrates you eat, the more Thiamine you need to convert them to energy.  

Discuss with your doctor the benefits of supplementing with Thiamine Vitamin B 1 and the rest of the B vitamins and magnesium.  Talk to a nutritionist to ensure you are getting a nutrient dense diet.

 

trents Grand Master

Welcome to the forum, Matt!

Are you back to eating significant amounts of gluten?

You say you "it comes up barely on the blood test". Which blood test do you refer to? Can you be more specific? I assume you are referring to a celiac antibody blood test but there is not just one. Do you have access to your medical record from recent testing and can you post the test result along with the reference range?

But the fact that you are still getting a weak positive means you are still producing celiac antibodies so I do not think the lower scores indicate you have converted somehow from having celiac disease to merely being gluten sensitive (aka, NCGS for Non Celiac Gluten Sensitivity, a better term than your "gluten intolerant" which is an umbrella term for all gluten-related disorders). Some celiacs report that they have gone into "remission" but it usually doesn't last.

Is there a common ingredient in the various "digestive enzyme" products you are taking that might cause the side effects you describe?

I' afraid that you are deceiving yourself into thinking you no longer have celiac disease and damage to your body is still happening, even though the outward symptoms are not what they used to be. And that brings up a good question. In the beginning when you were diagnosed with celiac disease, what were your symptoms? What led you to get tested for celiac disease? Are those symptoms, in fact, gone now?

Scott Adams Grand Master

Welcome to the forum!

What is your goal with the enzymes? Do you eat at restaurants and at other non-gluten-free homes? Is your goal to deal with the effects of possible cross-contamination with gluten? If so, you would need an enzyme designed for this, for example GliadinX, which is one of our sponsors. General enzymes may be good for lots of different things, but AN-PEP enzymes work specifically to break down gliadin in the stomach (small amounts only).

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    • knitty kitty
      @catnapt,  Wheat germ contains high amounts of lectins which are really hard to digest and can be irritating to the digestive tract.  They can stimulate IgG antibody production as your blood test shows.   Even beans have lectins.  You've simply eaten too many lectins and irritated your digestive tract.   You may want to allow your digestive tract to rest for a week, then start on gluten in "normal" food, not in concentrated vital wheat gluten. This explains it well: Lectins, agglutinins, and their roles in autoimmune reactivities https://pubmed.ncbi.nlm.nih.gov/25599185/
    • knitty kitty
      I take Now B-1 (100 mg) Thiamine Hydrochloride, and Amazing Formulas L-Tryptophan (1000 mg).   Both are gluten free and free of other allergens.  I've taken them for a long time and haven't had a problem with them. I take Vitamin A from BioTech called "A-25".  It's gluten and allergen free and made in the USA.  It's a powder form of Vitamin A.  I was having trouble digesting fats at one point, but found I tolerated the powder form much better and have stuck with it since.   Tryptophan and Vitamin A help heal the intestines as well as improves skin health.  I get Dermatitis Herpetiformis and eczema flairs when my stomach is upset.  So I'm healing the outside as well as the inside.   I take one 1000 mg Tryptophan before bedtime.   With the Thiamine HCl, take 100 mg to start.  If you don't notice anything, three hours later take another. You can keep increasing your dose in this manner until you do notice improvement.  Remember not to take it in the evening so it won't keep you too energized to sleep. When I first started Thiamine HCl, taking 500 mg to 1000 mg to start was recommended.  If you've been thiamine insufficient for a while, you do notice a big difference.  It's like the start of a NASCAR race: Zoom, Zoom, turn it up!   This scared or made some people uncomfortable, but it's just your body beginning to function properly, like putting new spark plugs in your engine.  I took 1000 mg all at once without food.  It kicked in beautifully, but I got a tummy ache, so take with food.  I added in Thiamine TTFD and Benfotiamine weeks later and felt like I was Formula One racing.  So cool.  You may feel worse for a couple days as your body adjusts to having sufficient thiamine.  Feels sort of like you haven't cranked your engine for a while and it backfires and sputters, but it will settle down and start purring soon enough.  Adjust your dose to what feels right for you, increasing your dose as long as you feel improvement.  You can reach a plateau, so stay there for several days, then try bumping it up again.  If no more improvements happen, you can stay at the plateau amount and experiment with increasing your Thiamine TTFD.  It's like being your own lab rat.  LoL Yes, take one Benfotiamine at breakfast and one at lunch.  Take the B Complex at breakfast. Take the TTFD at breakfast and lunch as well.  I like to take the vitamins at the beginning of meals and the NeuroMag at the end of meals.   You may want to add in some zinc.  I take Thorne Zinc 30 mg at breakfast at the beginning of the meal.   Are you getting sufficient Omega Threes?  Our brains are made up mostly of fat.  Flaxseed oil supplements, sunflower seed oil supplements (or eat the seeds themselves) can improve that.  Cooking with extra virgin olive oil, avocado oil, or coconut oil is also helpful.   @Wheatwacked likes phosphotidyl choline supplements for his Omega Threes.  He's also had dramatic health improvement by supplementing thiamine.  You're doing great!  Thank you for sharing your journey with us.  This path will smooth out.  Keep going!  
    • catnapt
      good luck! vital wheat gluten made me violently ill. I will touch the stuff ever again.  
    • catnapt
      I wouldn't consider this lucky. I can NOT tolerate the symptoms. And I googled it and I was not even getting 10 grams of gluten per day and I was extremely ill. They'd have to put me in the hospital. I'm not kidding.   I will have my first appt with a GI dr on March 4th   I will not eat gluten again - at least not on purpose   they are going to have to come up with a test that doesn't require it. 
    • xxnonamexx
      What Thiamine Hydrochloride brand do you take? Is it like the other vitamins I have added? What brand Tryptophan and amount do you take. Thanks
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