Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Result for biopsy

musicalmummy
 Share

Recommended Posts

musicalmummy Apprentice
musicalmummy
Posted

I’ve got my daughters biopsy results. It’s a most likely could be coeliac but still not definite .

I’ve got the paperwork if anyone is willing to decipher them 

Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Scott Adams Grand Master
Scott Adams
Posted

Feel free to post the results here, and your doctor is the best person to help you understand this. We're not doctors, but may be able to understand them. Please also post the reference ranges for a positive test for any celiac blood tests you share.

Link to comment
Share on other sites
musicalmummy Apprentice
musicalmummy
  • Author
Posted

E6A8683F-B48F-422A-8340-B4FF1625CBCB.webp.5a73f844481ec5f7fd86138eff1219e1.webp

Link to comment
Share on other sites
musicalmummy Apprentice
musicalmummy
  • Author
Posted

https://share.icloud.com/photos/08b3WaoN_BeT1YBn_zfNeMX2g

 

not sure if this works

Link to comment
Share on other sites
RMJ Mentor
RMJ
Posted

As I said answering another of your posts, the pathologist doesn’t have the whole picture (clinical signs/symptoms, serology) so lists all the options to explain what he/she saw. This is standard for pathologists. He/she suggests clinical/serological correlation.

Based on a previous post, your daughter has two positive antibody tests for celiac disease - this is the serological correlation.  Per biopsy her villi are shortened and there are increased epithelial lymphocytes - so two indications from biopsy for celiac disease.  I don’t understand why her doctor is reluctant to diagnose it as such.

Link to comment
Share on other sites
Scott Adams Grand Master
Scott Adams
Posted

I agree.

Link to comment
Share on other sites
musicalmummy Apprentice
musicalmummy
  • Author
Posted
2 hours ago, RMJ said:

As I said answering another of your posts, the pathologist doesn’t have the whole picture (clinical signs/symptoms, serology) so lists all the options to explain what he/she saw. This is standard for pathologists. He/she suggests clinical/serological correlation.

Based on a previous post, your daughter has two positive antibody tests for celiac disease - this is the serological correlation.  Per biopsy her villi are shortened and there are increased epithelial lymphocytes - so two indications from biopsy for celiac disease.  I don’t understand why her doctor is reluctant to diagnose it as such.

The gastroenterologist has both result and is the one who states it’s probable to be coeliac but he can’t 100% say.  And because of that my daughter wants to continue a normal diet and wait for the bloods and biopsy next year. I

Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


RMJ Mentor
RMJ
Posted

Can you get a second opinion?  Take the blood and biopsy results to another gastroenterologist? Some doctors, even gastroenterologists, can be real idiots when it comes to celiac disease.

I wonder what it would take for your daughter’s gastroenterologist to say that someone does have celiac disease.  Perhaps total villous atrophy?

Your daughter has autoimmune antibodies that are attacking her body.  Per a previous post, her deamidated gliadin peptide IgG is so high that it’s above the range of the test.  The transglutaminase IgA is five times the top of the normal range. She already has damage to her villi.  Continue feeding her gluten and the damage will just increase. She may have trouble absorbing nutrients just when her growing body needs them most.

Link to comment
Share on other sites
Paula O Newbie
Paula O
Posted

I was also recently diagnosed with celiac disease because of a biopsy taken during an endoscopy and followed up with blood tests, both ordered because my iron level was low. I have absolutely no symptoms if I eat regular food and so sorry for those that do. Is It possible to have celiac but feel perfectly normal and healthy? I have gone on a gluten free diet after seeing a registered dietitian but feel no different. I can’t even tell if I accidentally eat something on the “forbidden list”. How long does it take for intestines to return to normal after being on a gluten-free diet? And would it be possible after that time to start eating gluten again? Thanks, hopefully I’m not the only one with this issue.

Link to comment
Share on other sites
I.M.Celiac Apprentice
I.M.Celiac
Posted

I had 2 endoscopies because my GI “forgot” to look for Celiac. 
(So expensive!) He is my ex-doctor now. 


My height was probably stunted and my tooth enamel was definitely affected by undiagnosed Celiac. That may motivate your daughter to cut out gluten. Would love to have been taller with better teeth! 
 

Good luck!! 

Link to comment
Share on other sites
RMJ Mentor
RMJ
Posted
1 hour ago, Paula O said:

I was also recently diagnosed with celiac disease because of a biopsy taken during an endoscopy and followed up with blood tests, both ordered because my iron level was low. I have absolutely no symptoms if I eat regular food and so sorry for those that do. Is It possible to have celiac but feel perfectly normal and healthy? I have gone on a gluten free diet after seeing a registered dietitian but feel no different. I can’t even tell if I accidentally eat something on the “forbidden list”. How long does it take for intestines to return to normal after being on a gluten-free diet? And would it be possible after that time to start eating gluten again? Thanks, hopefully I’m not the only one with this issue.

Yes, it is called “silent celiac.”  I have no particular symptoms, although I find that I just feel better now that I am gluten free.  

It is not possible to return to eating gluten again after the intestines heal.  The antibodies would go back up and the damage return.

Link to comment
Share on other sites
RMJ Mentor
RMJ
Posted
2 hours ago, musicalmummy said:

The gastroenterologist has both result and is the one who states it’s probable to be coeliac but he can’t 100% say.  And because of that my daughter wants to continue a normal diet and wait for the bloods and biopsy next year. I

I do worry that if you and your daughter decide that she should go gluten free, she may not be particularly careful, since the doctor gave her the option to continue eating gluten.  If she only goes sort of gluten free it would be hard to evaluate at the one year retest.

Link to comment
Share on other sites
musicalmummy Apprentice
musicalmummy
  • Author
Posted
18 minutes ago, RMJ said:

I do worry that if you and your daughter decide that she should go gluten free, she may not be particularly careful, since the doctor gave her the option to continue eating gluten.  If she only goes sort of gluten free it would be hard to evaluate at the one year retest.

Yes I agree. Which is why I did let her make the choice. I felt if I made the decision and did everything at home to be gluten-free that she’d then just go out and eat gluten

Link to comment
Share on other sites
trents Grand Master
trents
Posted
6 minutes ago, musicalmummy said:

Yes I agree. Which is why I did let her make the choice. I felt if I made the decision and did everything at home to be gluten-free that she’d then just go out and eat gluten

You need to get a second opinion, musicalmumm. The first GI doc's conclusions are not in keeping with the actual biopsy results he reports. Not sure why he felt he could not conclusively say she has celiac disease. How old is your daughter?

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      125,809
    • Most Online (within 30 mins)
      7,748
    Mls
    Newest Member
    Mls
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.8k
    • Total Posts
      69k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • RMJ
      Implications of glutening after repairing villi

      By RMJ · Posted

      It will not undo all of the healing.  If it did, diagnosis of celiac disease would be much easier!  To have enough damage to see on an endoscopy requires several weeks of gluten ingestion. 
    • Jean Shifrin
      Implications of glutening after repairing villi

      By Jean Shifrin · Posted

      HI, I am new to this and am still in 'repair' mode, which I know will take time. But I'm wondering if anyone knows what happens if you ingest gluten after you have made a lot of progress in repairing your villi. Does anyone know if you just have a short-term issue? Or does an accidental ingestion of gluten derail all the work you've done and set you back to square one? Thanks.
    • Scott Adams
      Is McDonald's Safe for Gluten-Free Orders?

      By Scott Adams · Posted

      Hydrolyzed wheat is wheat protein that has been broken down into smaller components through a chemical or enzymatic process called hydrolysis. This ingredient can be found in various products, including cosmetics, personal care items, and some food products. For people with celiac disease, hydrolyzed wheat is generally not safe to consume because it still contains gluten proteins, even in its broken-down form. Though hydrolysis reduces the size of these proteins, it doesn’t fully remove the components that trigger an autoimmune response in people with celiac disease. In food products, hydrolyzed wheat protein still poses a risk and should be avoided. With regard to the McDonald's French fries, the total amount of hydrolyzed wheat in the flavoring is small, and the amount that ends up in an order of fries is even smaller, and likely below 20ppm. McDonald’s states that the fries are gluten-free by ingredient and free from cross-contact with gluten-containing foods in their dedicated fryers. Third-party tests and statements by McDonald's confirm gluten levels are below the FDA threshold for gluten-free labeling (20 parts per million or less). So, while McDonald’s USA fries may be gluten-free based on testing, some people with celiac disease still approach them cautiously due to the past concerns and individual sensitivities.
    • trents
      Is McDonald's Safe for Gluten-Free Orders?

      By trents · Posted

      Here is an excerpt from this article: https://pmc.ncbi.nlm.nih.gov/articles/PMC82695:   Studies have shown that various peptidases of fungal, plant, animal, or bacterial origin are able to hydrolyze gluten into harmless peptides. According to SDS‐PAGE pattern, proteolytic enzymes hydrolyze gliadins (Heredia‐Sandoval et al., 2016; Scherf et al., 2018; Socha et al., 2019; Wei et al., 2018, 2020). Bacterial peptidase (Krishnareddy & Green, 2017), fungal peptidase (Koning et al., 2005), and prolyl endopeptidases (PEPs) (Amador et al., 2019; Janssen et al., 2015; Kerpes et al., 2016; Mamo & Assefa, 2018) thoroughly degrade gliadin fractions to decrease gluten concentration and influence celiac disease. Aspergillus niger derived PEP (AN‐PEP) were assessed in clinical cases for their impact on modifying immune responses to gluten in celiac patients (Lähdeaho et al., 2014). Guerdrum and Bamforth (2012) reported that PEP addition in brewing technology decreased the prolamin and all of the identified immunopathogenic gluten epitopes in beer production (Akeroyd et al., 2016). On the contrary, many of the recent investigations which employed enzyme‐linked immunosorbent assay (ELISA), mass spectrometry, and Western blot analysis reported that PEP did not thoroughly destroy the whole gluten proteins (Allred et al., 2017; Colgrave et al., 2017; Fiedler et al., 2018; Panda et al., 2015), which indicates that beers treated with PEP are not safe for celiac disease patients. Anecdotally, this excerpt supports what we hear from the celiac community on this forum with regard to "gluten free" hydrolyzed wheat products and that is that some still react to them while many don't.
    • Scott Adams
      Anybody else have a similar experience...theories welcome as its something which i dont really understand.....

      By Scott Adams · Posted

      There aren't good studies that have been done on celiac disease remission, and I'm going from a distant memory of an older post here, but the longest remission that Dr. Stefano Guandalini from the University of Chicago Celiac Disease Center has witnessed was ~10 years, then the symptoms of celiac disease and the damage came back. The real issue though, is that you still could increase your risk of various related diseases and disorders by eating gluten, but again, celiac disease remission has not been studies enough to know what health risks you might face.
×
×
  • Create New...