Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

TTG 25

LP023
 Share

Recommended Posts

LP023 Contributor
LP023
Posted

I recently had a ttg and the results were 25 and I was told that it was positive by Gastro. I don’t hurt when I eat gluten but I feel awful when I eat vegetables and meat like on a keto diet. Could it be false positive? Is 25 high enough to be a for sure diagnoses? I can go several months with no issues at all and then get sick but eating bread, pasta, pizza and other foods that contain gluten don’t bother me.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


trents Grand Master
trents
Posted

Welcome to the forum, LP023!

Can you also supply the reference range for negative vs. positive? Without that it is not possible to say whether or not your score represents a strong positive as each lab uses a different standard.

Yes, it is possible that this represents a false positive but not likely. The tTG-IGA is considered to a celiac test with good specificity and good sensitivity. The next logical step is for you to schedule an endoscopy with biopsy of the small bowel lining. That is considered to be the gold standard test for celiac disease.

The fact that you do not experience GI distress when you consume gluten products certainly does not rule out celiac disease. A high percentage of those with active celiac disease do not have GI distress, at least not until the damage to the small bowel villi gets to an advanced stage. We call them "silent celiacs". The fact that you have trouble digesting meat and veggies could very well be caused by a damaged gut from celiac disease.

If you intend to go for the endoscopy/biopsy, make sure you do not start a gluten free diet until that is done.

Scott Adams Grand Master
Scott Adams
Posted

Did they also run any other celiac disease tests in your panel, for example DPG?

LP023 Contributor
LP023
Posted
  • Author
15 hours ago, trents said:

Welcome to the forum, LP023!

Can you also supply the reference range for negative vs. positive? Without that it is not possible to say whether or not your score represents a strong positive as each lab uses a different standard.

Yes, it is possible that this represents a false positive but not likely. The tTG-IGA is considered to a celiac test with good specificity and good sensitivity. The next logical step is for you to schedule an endoscopy with biopsy of the small bowel lining. That is considered to be the gold standard test for celiac disease.

The fact that you do not experience GI distress when you consume gluten products certainly does not rule out celiac disease. A high percentage of those with active celiac disease do not have GI distress, at least not until the damage to the small bowel villi gets to an advanced stage. We call them "silent celiacs". The fact that you have trouble digesting meat and veggies could very well be caused by a damaged gut from celiac disease.

If you intend to go for the endoscopy/biopsy, make sure you do not start a gluten free diet until that is done.

I think 0-3 negative

4-10 week positive and anything over 10 positive. 

LP023 Contributor
LP023
Posted
  • Author
2 hours ago, Scott Adams said:

Did they also run any other celiac disease tests in your panel, for example DPG?

Not that I know of. CRP was fine. I guess that’s for inflammation.  Vitamins were fine. Running a colonoscopy, swallow test and upper endo but the wait is long. I haven’t eaten gluten in 4 days. Ate a salad with no dressing and pain started. Mine seems to be vegetables and fruit. Sometimes meat. Makes no sense to me. 

trents Grand Master
trents
Posted

If you eliminate or cut back on gluten before all testing is complete you will undermine the results. Since you say gluten doesn't bother you, you should be able to weather that period without undue suffering. Can you do dairy and eggs without discomfort so as to meet protein needs?

LP023 Contributor
LP023
Posted
  • Author

Eggs is a no. Dairy sometimes. It’s looking like 2 months before the tests will be done. I thought I would try it for awhile to see what happened if I cut out gluten for a week. I’ve read that the blood test was 98% accurate. 25 is 15 over the positive limit but I’ve seen where some people were in the 100s. I had Covid a year ago and since then I’ve felt hungry non stop and stomach noises are constant. Most days I feel good. Just some really bad weeks scattered in. 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


trents Grand Master
trents
Posted

If you eliminate or cut back on gluten before all testing is complete you will undermine the results. Since you say gluten doesn't bother you, you should be able to weather that period without undue suffering. Can you do dairy and eggs without discomfort so as to meet protein needs?

The Mayo Clinic Guidelines for the pretest gluten challenge leading up to the endoscopy/biopsy is the daily consumption of two slices of wheat bread (or the gluten equivalent) for two weeks prior. That should help you in your planning.

  • 2 weeks later...
Raptorsgal Enthusiast
Raptorsgal
Posted

Mine ttg. was 80 a lot higher . I also stop gluten it’s been a few days seem to be helping gluten in everything 

Scott Adams Grand Master
Scott Adams
Posted

As @trents mentioned, be sure not to eliminate gluten until all tests for celiac disease have been completed.

Raptorsgal Enthusiast
Raptorsgal
Posted

The doctor pretty sure I had it there’d been no test scheduled if they are it could be months and months .

oat milk and granola are they l always gluten free so confusing 

trents Grand Master
trents
Posted
2 minutes ago, Raptorsgal said:

oat milk and granola are they l always gluten free so confusing 

Oats and granola are not necessarily gluten free because of the likelihood of cross contamination with wheat in the field, in transport, in storage and in processing. Milk is gluten free.

Raptorsgal Enthusiast
Raptorsgal
Posted

It’s so hard I needed to eat something hopeful things get better waiting for a library book

  • 2 weeks later...
RecoveredCeliac Apprentice
RecoveredCeliac
Posted
On 1/26/2023 at 2:12 PM, LP023 said:

25 is 15 over the positive limit 

doesn't matter if other people were hundreds over normal range

ttg iga?    ttg iga is over 99% accurate for celiac

If you have 15 above normal ttg iga then you are definitely positive

 

LP023 Contributor
LP023
Posted
  • Author
51 minutes ago, RecoveredCeliac said:

doesn't matter if other people were hundreds over normal range

ttg iga?    ttg iga is over 99% accurate for celiac

If you have 15 above normal ttg iga then you are definitely positive

 

Most likely am positive but I know when I worked in the lab several years ago I learned really quick false positives for several things aren’t as uncommon as we think. Other autoimmune diseases can cause false positives. HIV antibody testing is a huge false positive risk and they say it’s 99% accurate. Every time we had a positive it was sent off for confirmation testing to make sure it was really positive. As far as I know there isn’t another blood test to confirm celiacs if one comes back positive but it’s been awhile since I worked in that field. 

trents Grand Master
trents
Posted
3 hours ago, LP023 said:

Most likely am positive but I know when I worked in the lab several years ago I learned really quick false positives for several things aren’t as uncommon as we think. Other autoimmune diseases can cause false positives. HIV antibody testing is a huge false positive risk and they say it’s 99% accurate. Every time we had a positive it was sent off for confirmation testing to make sure it was really positive. As far as I know there isn’t another blood test to confirm celiacs if one comes back positive but it’s been awhile since I worked in that field. 

There are a number of celiac antibody tests that can be ordered. The most popular one with PC physicians is the tTG-IGA, and it may be the best all around test for celiac disease but full panel is always better.

https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

LP023 Contributor
LP023
Posted
  • Author

A67EA4BA-5F13-40D1-A107-B08FC164D101.png.8e68f67083560949b842fe161a4a8459.png/

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. trents
      - trents replied to Atl222's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      5

      Increased intraepithelial lymphocytes after 10 yrs gluten-free

      Cristiana, that sounds like a great approach and I will be looking forward to the results. I am in the same boat as you. I don't experience overt symptoms with minor, cross contamination level exposures so I sometimes will indulge in those "processed on equipment that also processes wheat . . ." or items that don't specifically claim to be gluten free but...
    2. cristiana
      - cristiana replied to Atl222's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      5

      Increased intraepithelial lymphocytes after 10 yrs gluten-free

      I've been reflecting on this further. The lowest TTG I've ever managed was 4.5 (normal lab reading under 10). Since then it has gone up to 10. I am not happy with that. I can only explain this by the fact that I am eating out more these days and that's where I'm being 'glutened', but such small amounts that I only occasionally react. I...
    3. Mike Maurillo
      0

      Celiac Friendly Sports Camps - Academy Camps - Virtual Open House

      until
      Hi everyone, I’m Mike, one of the co-founders of Academy Camps, a sleepaway sports camp for kids ages 10 to 16. I’m posting here because one of our camp families whose daughter has Celiac encouraged me to share our experience wit...
    4. lizzie42
      - lizzie42 posted a topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      0

      Low iron and vitamin d

      Hi, I posted before about my son's legs shaking after gluten. I did end up starting him on vit b and happily he actually started sleeping better and longer. Back to my 4 year old. She had gone back to meltdowns, early wakes, and exhaustion. We tested everything again and her ferritin was lowish again (16) and vit d was low. After a couple weeks...
    5. Scott Adams
      - Scott Adams replied to Atl222's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      5

      Increased intraepithelial lymphocytes after 10 yrs gluten-free

      Celiac disease is the most likely cause, but here are articles about the other possible causes:
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,210
    • Most Online (within 30 mins)
      7,748
    ngeragosian
    Newest Member
    ngeragosian
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • trents
      Increased intraepithelial lymphocytes after 10 yrs gluten-free

      By trents · Posted

      Cristiana, that sounds like a great approach and I will be looking forward to the results. I am in the same boat as you. I don't experience overt symptoms with minor, cross contamination level exposures so I sometimes will indulge in those "processed on equipment that also processes wheat . . ." or items that don't specifically claim to be gluten free but do not list gluten containing grains in their ingredient list. But I always wonder if I am still experiencing sub acute inflammatory reactions. I haven't had any celiac antibody blood work done since my diagnosis almost 25 years ago so I don't really have any data to go by.   
    • cristiana
      Increased intraepithelial lymphocytes after 10 yrs gluten-free

      By cristiana · Posted

      I've been reflecting on this further. The lowest TTG I've ever managed was 4.5 (normal lab reading under 10).  Since then it has gone up to 10.   I am not happy with that.  I can only explain this by the fact that I am eating out more these days and that's where I'm being 'glutened', but such small amounts that I only occasionally react. I know some of it is also to do with eating products labelled 'may contain gluten' by mistake - which in the UK means it probably does! It stands to reason that as I am a coeliac any trace of gluten will cause a response in the gut.  My villi are healed and look healthy, but those lymphocytes are present because of the occasional trace amounts of gluten sneaking into my diet.   I am going to try not to eat out now until my next blood test in the autumn and read labels properly to avoid the may contain gluten products, and will then report back to see if it has helped!
    • lizzie42
      Low iron and vitamin d

      By lizzie42 · Posted

      Hi, I posted before about my son's legs shaking after gluten. I did end up starting him on vit b and happily he actually started sleeping better and longer.  Back to my 4 year old. She had gone back to meltdowns, early wakes, and exhaustion. We tested everything again and her ferritin was lowish again (16) and vit d was low. After a couple weeks on supplements she is cheerful, sleeping better and looks better. The red rimmed eyes and dark circles are much better.   AND her Ttg was a 3!!!!!! So, we are crushing the gluten-free diet which is great. But WHY are her iron and vit d low if she's not getting any gluten????  She's on 30mg of iron per day and also a multivitamin and vit d supplement (per her dr). That helped her feel better quickly. But will she need supplements her whole life?? Or is there some other reason she's not absorbing iron? We eat very healthy with minimal processed food. Beef maybe 1x per week but plenty of other protein including eggs daily.  She also says her tummy hurts every single morning. That was before the iron (do not likely a side effect). Is that common with celiac? 
    • Scott Adams
      Increased intraepithelial lymphocytes after 10 yrs gluten-free

      By Scott Adams · Posted

      Celiac disease is the most likely cause, but here are articles about the other possible causes:    
    • xxnonamexx
      FDA looking for input on Celiac Gluten sensitivity labeling PLEASE READ and submit your suggestions

      By xxnonamexx · Posted

      Please read: https://www.fda.gov/news-events/press-announcements/fda-takes-steps-improve-gluten-ingredient-disclosure-foods?fbclid=IwY2xjawPeXhJleHRuA2FlbQIxMABicmlkETFzaDc3NWRaYzlJOFJ4R0Fic3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHrwuSsw8Be7VNGOrKKWFVbrjmf59SGht05nIALwnjQ0DoGkDDK1doRBDzeeX_aem_GZcRcbhisMTyFUp3YMUU9Q
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.