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Tissue Transgluten


Raptorsgal

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Raptorsgal Enthusiast

I had a blood test the tissue transgluten it was very high  it called tTg 

there a other test I don’t think I was tested for it Gliadin  DGP. Seem like the Tissue Transgluten for me was high maybe the other test wasn’t needed 

 

 


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Scott Adams Grand Master

Normally in a celiac blood panel several tests are done, and this article helps explain them:

 

Raptorsgal Enthusiast

Sounds like I may not need any more test other then the blood test I stop having gluten hike that helps . 
 

still have some issue hopeful it improve 

Thanks for the article seeing a specialist next month 

Scott Adams Grand Master

As the article mentions, normally you would not go on a gluten-free diet until AFTER all tests for celiac disease have bee completed, otherwise the tests may yield false negative results.

Raptorsgal Enthusiast

Ttg blood test was high thanks 

Scott Adams Grand Master

Will they schedule an endoscopy for you? That would be the normal next step,  but in some countries if your tTG results are 5-10x the positive celiac level, they diagnose it using only blood test results.

Raptorsgal Enthusiast

I’m not sure I’m seeing a gastroenterologist next week we will see what the doctor says. I hope that I don’t have  to I get anxiety with test. My blood test maybe enough 


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Scott Adams Grand Master

Let us know how it turns out!

Raptorsgal Enthusiast

Thanks 

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    • trents
      Welcome to the forum, @ABP! We can't comment on the test numbers you give as you didn't include the range for negative. Different labs use different units and different ranges. There are no industry standards for this so we need more information. If your daughter doesn't have celiac disease she still could have NCGS (Non Celiac Gluten Sensitivity) which some experts believe can be a precursor to celiac disease and is 10x more common than celiac disease. However, there is no test for it yet but it does share many of the same symptoms with celiac disease. Both require complete abstinence from gluten.  It is seldom the case during testing where all tests are positive, even for those who do have celiac disease. This is no different than when diagnosing other medical conditions and that is why it is typical to run numbers of tests that come at things from different angles when seeking to arrive at a diagnosis. It seems like you are at the point, since you have had both blood antibody testing and endoscopy/biopsy done, that you need to trial the gluten free diet. If her symptoms improve then you know all you need to know, whatever you label you want to give it. But given that apparently at least one celiac antibody blood test is positive and she has classic celiac symptoms such as slow growth, constipation and bloating, my money would be on celiac disease as opposed to NCGS.
    • ABP
      My nine-year-old daughter has suffered with severe constipation and bloating for years as well as frequent mouth sores, and keratosis Polaris on her arms. She also has recently decreased on her growth curve her % going down gradually.  After seeing a gastroenterologist, her IgG GLIADIN (DEAMIDATED) AB (IGG) was 22.4 while her IGA was normal. Her TISSUE TRANSGLUTAMINASE AB, IGA was 11.9.  Most recently her genetic test for celiac was positive.  After an endoscopy her tissue showed inflammation of the tissue as well as , increased intraepithelial lymphocytes (IELs) but there was no blunting of the change in the villi.    It seems that every result that we get one out of two things positive rather than all leading to an inconclusive diagnosis. While we do have another appointment with the doctor to go over the results. I'm curious based on this information what others think.    I would hate to have her eliminate gluten if not necessary- but also don't want to not remove if it is necessary.    Signed Confused and Concerned Mama
    • Scott Adams
      I guess using "GF" instead of "PL" would have been too easy! 😉
    • trents
      I was wrong, however, about there being no particular health concerns associated with high total IGA: https://www.inspire.com/resources/chronic-disease/understanding-high-iga-levels-causes-impacts/ So maybe the physician's "borderline" remark is relevant to that.
    • trents
      Sometimes that is the case but what is curious to me is the remark by your physician about being "borderline". I assume he was referring to the total IGA score but it just seems like an irrelevant remark when it is on the high side rather than being deficient.
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