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Help with test results

Cookie07
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Cookie07 Newbie
Cookie07
Posted

Please help, my doctor sent me to get tested for Celiac and I went to Quest, I will not be able to see her for a month.  Two sections from my test came back in red, can someone tell me what these results mean? Do I have celiac, what do the red ones mean?

(TTG) AB, IGG = 1.9

(TTG) AB, IGA = <1.0

The next two are in red

Gliadin (Deamidated) AB, IgA = 27.9 H

Gliadin (Deamidated) AB, IGG = 19.3 H

Immunoglobulin A = 280

Your help is appreciated.

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trents Grand Master
trents
Posted
(edited)

Welcome to the forum, Cookie07!

The red ones are positive for celiac disease. You don't have to have all the tests be positive in order for it to point to celiac disease. That's why your doctor ordered several different kinds of tests. What one misses, others may catch. By the way, you weren't already on a gluten free or a reduced gluten diet were you when the blood draw was made?

The next step will likely be an endoscopy with biopsy of the small bowel lining to confirm the results of the blood antibody tests. You should not cut back on gluten before that is done. The endoscopy/biopsy is considered to be the gold standard for diagnosing celiac disease.

What is Quest?

Edited by trents
Cookie07 Newbie
Cookie07
Posted
  • Author

Thank you so much for your help. To answer your question, yes I was still eating gluten when I took the test and the test were preformed by Quest.
 

Your feedback is much appreciated. Have a great rest of your week.

trents Grand Master
trents
Posted

The tTG-IGA is the most popular single test for celiac disease ordered by physicians and, unfortunately and many times the only one. The tTG-IGA combines good specificity for celiac disease and good sensitivity and it is relatively economical. But for whatever reason, according to one study I read, it misses about 20% of those who do have celiac disease from white European extraction and about 80% of those who do have celiac disease from black African decent. So, it's not perfect and your results underscore the value of running several different antibody tests. There is also the possibility that you have NCGS (Non Celiac Gluten Sensitivity) which is considered by some experts to be a precursor (sometimes) to celiac disease.

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    • trents
      Awaiting diagnosis

      By trents · Posted

      I would ask for a total IGA test (aka, Immunoglobulin A (IgA) and other names as well) to check for IGA deficiency. That test should always be ordered along with the TTG IGA. If someone is IGA deficient, their individual celiac IGA test scores will be artificially low which can result in false negatives. Make sure you are eating generous amounts of gluten leading up to any testing or diagnostic procedure for celiac disease to ensure validity of the results. 10g of gluten daily for a period of at least 2 weeks is what current guidelines are recommending. That's the amount of gluten found in about 4-6 slices of wheat bread.
    • jlp1999
      Awaiting diagnosis

      By jlp1999 · Posted

      There was not a total IGA test done, those were the only two ordered. I would say I was consuming a normal amount of gluten, I am not a huge bread or baked goods eater
    • trents
      Awaiting diagnosis

      By trents · Posted

      Were you consuming generous amounts of gluten in the weeks leading up to the blood draw for the antibody testing? And was there a Total IGA test done to test for IGA deficiency?
    • jlp1999
      Awaiting diagnosis

      By jlp1999 · Posted

      Thank you for the reply. It was the TTG IGA that was within normal limits
    • trents
      Awaiting diagnosis

      By trents · Posted

      Welcome to the forum, @jlp1999! Which IGA test do you refer to as being normal? TTG-IGA? Total IGA? DGP-IGA? Yes, any positive on an IGA or an IGG test can be due to something other than celiac disease and this is especially true of weak positives. Villous atrophy can also be cause by other things besides celiac disease such as some medications, parasitic infections and even some foods (especially dairy from an intolerance to the dairy protein casein). But the likelihood of that being the case is much less than it being caused by celiac disease.
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