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TTG IGA ANTIBODY test


Marylee

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Marylee Rookie

I would like to know the correct range for this test. I have found information online that differs from the lab my physician uses. Thank you for any help you may provide. 


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trents Grand Master
(edited)

Welcome to the forum, Marylee!

There is no industry standard range for any of the celiac antibody tests. Each lab uses their own range scale as they use their own formulation when developing the test. All we can suggest is that you supply us with your numerical result and the range (negative vs. positive) used by the lab that analyzed it if you want us to weigh in on the meaning of the results.

Edited by trents
Marylee Rookie

Thank you! It’s actually for my mother. Her result was 10.38. 

trents Grand Master

We need more than your mother's score. We need the range used by the lab. Where is the negative vs. positive divide?

For instance:

<7 = negative

>7 = positive

 

Marylee Rookie

Here is the copy of the test results. While it appears that it’s clearly negative, I question this lab’s scale as most others I have seen state that over 10 is positive. 

RMJ Mentor

The units of measure for this test are not absolute. Each lab uses different units for this test so  one has to go by the lab range.

An example of what I mean by different units: Imagine someone is measuring length, and one person says something is three bananas long, and another says the same thing is six oranges long.

Marylee Rookie

Thank you for your help. Much appreciated.


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trents Grand Master
(edited)
39 minutes ago, Marylee said:

Here is the copy of the test results. While it appears that it’s clearly negative, I question this lab’s scale as most others I have seen state that over 10 is positive. 

"Here is a copy of the results"? The results you speak of are missing from the post. You only have a few minutes to edit any post before that feature is turned off. This is an anti spam measure.

I take it that you feel you may actually have celiac disease even though the one test you have had was negative. Am I correct? What symptoms do you have?

It's a shame they only ran that one antibody test for celiac disease. There are a number of other antibody tests that could have been run and should have. Here is a primer for celiac disease antibody diagnostic tests: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

We often have people on the forum report negative tTG-IGA results but when other tests are run they are positive.

There is also the possibility that you have NCGS (Non Celiac Gluten Sensitivity) for which there is not test available yet. NCGS is 10x more common than celiac disease and shares many of the same symptoms with celiac disease. To arrive at a diagnosis of NCGS, celiac disease must first be ruled out. In both cases, the antidote is the same: elimination of gluten from the diet.

Edited by trents
  • 3 weeks later...
Marylee Rookie

Thank you for checking in with me and for the information stated above. 

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    • trents
      I would ask for a total IGA test (aka, Immunoglobulin A (IgA) and other names as well) to check for IGA deficiency. That test should always be ordered along with the TTG IGA. If someone is IGA deficient, their individual celiac IGA test scores will be artificially low which can result in false negatives. Make sure you are eating generous amounts of gluten leading up to any testing or diagnostic procedure for celiac disease to ensure validity of the results. 10g of gluten daily for a period of at least 2 weeks is what current guidelines are recommending. That's the amount of gluten found in about 4-6 slices of wheat bread.
    • jlp1999
      There was not a total IGA test done, those were the only two ordered. I would say I was consuming a normal amount of gluten, I am not a huge bread or baked goods eater
    • trents
      Were you consuming generous amounts of gluten in the weeks leading up to the blood draw for the antibody testing? And was there a Total IGA test done to test for IGA deficiency?
    • jlp1999
      Thank you for the reply. It was the TTG IGA that was within normal limits
    • trents
      Welcome to the forum, @jlp1999! Which IGA test do you refer to as being normal? TTG-IGA? Total IGA? DGP-IGA? Yes, any positive on an IGA or an IGG test can be due to something other than celiac disease and this is especially true of weak positives. Villous atrophy can also be cause by other things besides celiac disease such as some medications, parasitic infections and even some foods (especially dairy from an intolerance to the dairy protein casein). But the likelihood of that being the case is much less than it being caused by celiac disease.
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