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Hidden Sources of Gluten?


ac5858

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ac5858 Newbie

I have been gluten-free for 12 years now and of course deal with the occasional flare-ups of getting "glutened." I recently went on an SSRI (Zoloft/Sertaline), and have been experiencing the strangest symptoms, and can't help but wonder if they are due to gluten. I have been extremely fatigued, horrible headaches, canker sores that will not go away, acne, and brain fog. 

Has anyone else experienced something similar? 


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trents Grand Master

How long have you been taking the SSRI? Maybe it's a matter of your body needing more time to adjust to it or maybe the dosage needs to be adjusted.

Also, as you know, wheat starch can be used in pills as a filler. See what you can find out from the dispensing pharmacy and if necessary they can give you information about their supplier to ask more detailed questions.

Many medications also leach or block the uptake of certain nutrients and that could figure into your symptoms.

There is also the possibility that you have developed an additional food intolerance that mimics the effect of gluten. Do you have celiac disease or NCGS (Non Celiac Gluten Sensitivity)?

knitty kitty Grand Master

@ac5858,

After being on the gluten free diet for such a long time, it is more likely you have developed nutritional deficiencies.

1 hour ago, ac5858 said:

 I have been extremely fatigued, horrible headaches, canker sores that will not go away, acne, and brain fog. 

These are all symptoms of Thiamine deficiency.  I know from experience, thiamine deficiency will cause Depression, extreme fatigue, headaches and brain fog, and canker sores and acne.

Nutritional deficiencies can occur on the gluten free diet.  Processed gluten free facsimile foods are not enriched with vitamins and minerals lost in processing like gluten based foods are required by law to do.  

Thiamine is Vitamin B 1.  Thiamine works with magnesium (magnesium glycinate is the gentleman form) and the other seven B vitamins.  Thiamine can only be stored for three weeks, with deficiency symptoms occurring within a week.  One can have a subclinical thiamine deficiency for a long time.  Symptoms can wax and wane depending on how much Thiamine is included in the diet daily.  

Vitamin D deficiency is also a cause of depression.

My depression did NOT resolve on antidepressants.  Only after supplementing with Vitamin D (my lab test showed severe Vitamin D deficiency) and Thiamine.  

Here are some articles that explain more in depth....

 

For those canker sores...

Recurrent aphthous stomatitis and thiamine deficiency

https://pubmed.ncbi.nlm.nih.gov/8974135/

AND...

Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy

https://pubmed.ncbi.nlm.nih.gov/1941656/

 

DEPRESSION....

Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial

https://pubmed.ncbi.nlm.nih.gov/26984349/

AND...

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/?report=reader

 

Vitamin D and depression

Vitamin D and Depression: A Critical Appraisal of the Evidence and Future Directions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970300/

 

DIET...

Antidepressant foods: An evidence-based nutrient profiling system for depression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147775/?report=reader

 

 

Do get checked for vitamin and mineral deficiencies!  Discuss with your doctor the benefits of supplementing with extra thiamine and a B Complex, and Vitamin D, and magnesium.

Hope this helps!

plumbago Experienced

I've gotten aptheous (spelling?) ulcers in my mouth - but it's been a while. It may have been due to tomatoes, sugar, or something viral. I was never really able to nail it down for sure. I did change to a toothpaste without SLS. For the most part, everything I did (new toothpaste, trying hard not always successfully to reduce sugar)

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    • knitty kitty
      Check your multivitamin to see if it contains Thiamine Mononitrate, which is a "shelf-stable" form of thiamine that doesn't break down with exposure to light, heat, and time sitting on a shelf waiting to be sold.  Our bodies have difficulty absorbing and utilizing it.  Only 30% is absorbed and less can be utilized.   There's some question as to how well multivitamins dissolve in the digestive tract.  You can test this at home.  YouTube has instructional videos.   Talk to your nutritionist about adding a B Complex.  The B vitamins are water soluble, so any excess is easily excreted if not needed.  Consider adding additional Thiamine in the forms Benfotiamine or TTFD (tetrahydrofurfuryl disulfide) or thiamine hydrochloride.   Thiamine is needed to help control electrolytes.  Without sufficient thiamine, the kidneys loose electrolytes easily resulting in low sodium and chloride.   We need extra thiamine when we're emotionally stressed, physically ill, and when we exercise regularly, are an athlete, or do physical labor outdoors, and in hot weather.  Your return to activities and athletics may have depleted your thiamine and other B vitamins to a point symptoms are appearing.   The deficiency symptoms of B vitamins overlap, and can be pretty vague, or easily written off as due to something else like being tired after a busy day.  The symptoms you listed are the same as early B vitamin deficiency symptoms, especially Thiamine.  Thiamine deficiency symptoms can appear in as little as three days.  I recognize the symptoms as those I had when I was deficient.  It can get much worse. "My symptoms are as follows: Dizziness, lightheaded, headaches (mostly sinus), jaw/neck pain, severe tinnitus, joint stiffness, fatigue, irregular heart rate, post exercise muscle fatigue and soreness, brain fog, insomnia.  Generally feeling unwell." I took a B 50 Complex twice a day and extra thiamine in the forms Benfotiamine and TTFD.  I currently take the Ex Plus supplement used in this study which shows B vitamins, especially Thiamine B 1, Riboflavin B2, Pyridoxine B 6, and B12 Cobalamine are very helpful.   A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial https://pmc.ncbi.nlm.nih.gov/articles/PMC10542023/
    • Scatterbrain
      I am taking a multivitamin which is pretty bolstered with B’s.  Additional Calcium, D3, Magnesium, Vit C, and Ubiquinol.  Started Creapure creatine monohydrate in June for athletic recovery and brain fog.  I have been working with a Nutritionist along side my Dr. since February.  My TTG IGA levels in January were 52.8 and my DGP IGA was >250 (I don’t know the exact number since it was so high).  All my other labs were normal except Sodium and Chloride which were low.  I have more labs coming up in Dec.  I make my own bread, and don’t eat a lot of processed gluten-free snacks.
    • knitty kitty
      @Scatterbrain, What supplements are you taking? I agree that the problem may be nutritional deficiencies.  It's worth talking to a dietician or nutritionist about.   Did you get a Marsh score at your diagnosis?  Was your tTg IgA level very high?  These can indicate more intestinal damage and poorer absorption of nutrients.   Are you eating processed gluten free food stuffs?  Have you looked into the Autoimmune Protocol Diet?  
    • knitty kitty
      Vitamin and mineral deficiencies can make TMJ worse.  Vitamins like B12 , Thiamine B1, and Pyridoxine B6 help relieve pain.  Half of the patients in one study were deficient in these three vitamins in one study below. Malabsorption of vitamins and minerals is common in celiac disease.  It's important to eat healthy nutrient dense diets like the Autoimmune Protocol Diet, a Paleo diet that has similarities to the Mediterranean diet mentioned in one of the studies.   Is there a link between diet and painful temporomandibular disorders? A cross-sectional study https://pmc.ncbi.nlm.nih.gov/articles/PMC12442269/   Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights https://pmc.ncbi.nlm.nih.gov/articles/PMC11397166/   Serum nutrient deficiencies in the patient with complex temporomandibular joint problems https://pmc.ncbi.nlm.nih.gov/articles/PMC2446412/  
    • Iam
      Yes.  I have had the tmj condition for 40 years. My only help was strictly following celiac and also eliminating soy.  Numerous dental visits and several professionally made bite plates  did very little to help with symptoms
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