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Lost in test results

hanna246
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hanna246 Newbie
hanna246
Posted

I have autoimmune disorders  and was tested for gluten  sensitivity. No symptoms.   But Dr. Came back and said  I have Celiac disease. Family always playing Drs.. Said the tests show I am moderately positive.  So don't  worry.  And well I don't  understand  test results???

Anti Gliadin Ab, IgA. 0-19 units      >150^

Tissue Transglutaminase.  0- 3 U/mL.      18^

Can someone  help me understand. So I can explain this to my family. 

Thank you Hanna246

 

 

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trents Grand Master
trents
Posted
(edited)

The tissue transglutaminase is a mild positive but the anti Gliadin AB, IGA is strongly positive. Both have high specificity with regard to celiac disease. So, the chances of these positives being caused by something other than celiac disease is remote. Are you scheduled for an endoscopy with biopsy yet to confirm the findings of the blood work?

For the two tests you entered in your first post, the "normal" range is given in the first set of numbers and your score is given in the number with the ^ by it. ^ means higher than normal. An arrow head pointing down (v) besides the number would mean lower than normal.

Edited by trents
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hanna246 Newbie
hanna246
Posted
  • Author
  • Solution
1 hour ago, hanna246 said:

I have autoimmune disorders  and was tested for gluten  sensitivity. No symptoms.   But Dr. Came back and said  I have Celiac disease. Family always playing Drs.. Said the tests show I am moderately positive.  So don't  worry.  And well I don't  understand  test results???

Anti Gliadin Ab, IgA. 0-19 units      >150^

Tissue Transglutaminase.  0- 3 U/mL.      18^

Can someone  help me understand. So I can explain this to my family. 

Thank you Hanna246

 

 

 

trents Grand Master
trents
Posted

Many people with celiac disease are asymptomatic. We call the "silent" celiacs. I was one. Autoimmune disorders tend to cluster.

See my edit in the last post for understanding your test results.

hanna246 Newbie
hanna246
Posted
  • Author

This helps alot in understanding these tests. I will ask the  Dr. About having  a biopsy. Thank you

trents Grand Master
trents
Posted

By the way, welcome to the forum, hanna246!

Don't start the gluten free diet until you find out if you will be having a biopsy. You don't want healing of the small bowel villi to happen until after the biopsy since that might invalidate the biopsy results.

RMJ Mentor
RMJ
Posted

The Anti Gliadin Ab IgA is so high that it is above the range where the test gives a specific value for the answer. It is greater than (>) 150.  It could be 151, it could be 1500. It is not moderately positive, it is a very high positive.

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trents Grand Master
trents
Posted
7 hours ago, trents said:

The tissue transglutaminase is a mild positive but the anti Gliadin AB, IGA is strongly positive. Both have high specificity with regard to celiac disease. So, the chances of these positives being caused by something other than celiac disease is remote. Are you scheduled for an endoscopy with biopsy yet to confirm the findings of the blood work?

For the two tests you entered in your first post, the "normal" range is given in the first set of numbers and your score is given in the number with the ^ by it. ^ means higher than normal. An arrow head pointing down (v) besides the number would mean lower than normal.

I am mistaken about the symbols in the test report. Greater than is ">". Less than is "<". Not sure what the "^" stands for but the essence of what I said about the numeric values themselves is correct. One is a moderate positive and the other is a strong positive.

hanna246 Newbie
hanna246
Posted
  • Author
6 hours ago, trents said:

By the way, welcome to the forum, hanna246!

Don't start the gluten free diet until you find out if you will be having a biopsy. You don't want healing of the small bowel villi to happen until after the biopsy since that might invalidate the biopsy results.

Thank you.

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    • Jason Hi
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      How long was your gluten challenge? I hope it was longer than a week. If not, your testing was likely invalid. Recently upgraded guidelines call for the daily consumption of at least 10g of gluten (about the amount found in 4-6 slices of wheat bread) for at least two weeks prior to either the blood antibody test draw or the endoscopy/biopsy. And if you had been gluten free for all those years, you likely had lost any tolerance to gluten you may have had when consuming it regularly. That's probably why it was such a tough sledding experience. Before I was diagnosed, I had very minor GI symptoms. Now, after many years of being gluten free, I get violently ill for hours if I get a good slug of gluten, like when I got my wife's wheat biscuits mixed up with the gluten free ones she made me.
    • Jason Hi
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      Well, the next step would logically be to commit in a serious way to the gluten-free diet and see if you have significant improvement in your symptoms. You should see improvement very soon with regard to GI issues and within weeks if there are other symptoms if gluten is indeed the issue. If there is significant improvement after going gluten free, that would tell you that you must avoid gluten and given the test results you already have, the logical conclusion is NCGS. As I said, an NCGS diagnosis is arrived at by first ruling out celiac disease, which seems to have been done. Then you could go back to that doctor with the other evidence component (improvement of symptoms with gluten-free eating) and ask if he/she would now be willing to declare an official dx of NCGS and give you a note. Or, you could book an appointment with another doctor who could look at your test results online, together with symptom improvement after going gluten-free, who might be more cooperative. I would seek out a younger practitioner as they are more likely to not be operating on outdated info about gluten disorders. By the way, NCGS is about 10x more common than celiac disease. 
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