Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Positive gliadin (deamidated) IgG, normal everything else?

phosphene
 Share

Recommended Posts

phosphene Newbie
phosphene
Posted

I've been searching through this forum and online but haven't gotten a clear answer, so I thought I would post my results specifically. My understanding is that a high gliadin IgG isn't really enough for a diagnosis, but what does it mean? I'm pretty confused. I definitely do have stomach and inflammation issues, but is it celiac or a sensitivity? With my endoscopy and biopsies I haven't gotten these results and my doctor recommended to do another biopsy. But I'd like to know what you guys think and if you've seen this before. Thank you in advance <3

Here are my blood test results:

- tissue transglutaminase Ab, IgG: Normal <1.0

- tissue transglutaminase Ab, IgA Normal <1.0

- gliadin (deamidated) Ab (IgA). Normal. <1.0 

- gliadin (deamidated) Ab (IgG). High. 209.2 U/mL. within high range greater than null.

(Value Interpretation ----- -------------- <15.0 Antibody not detected > or = 15.0 Antibody detected)

- immunoglobulin A. Normal. 303 mg/dL. within normal range between 47 and 310.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


trents Grand Master
trents
Posted

Welcome to the forum, phosphene!

DGP IGG is quite high! It is not borderline. It certainly can indicate celiac disease but the test is not as specific as the tTG-IGA for celiac disease.

One thing that can throw false negatives for the tTG-IGA is low total serum IGA but that test was not ordered.  It should have been. Another thing that can drive the tTG-IGA score downward is commencing a gluten free or lower gluten diet ahead of the blood draw.

Scott Adams Grand Master
Scott Adams
Posted

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease:
 

Quote

The sensitivity of the DGP-IgG test is reported to range from 75% to 85%, which means it can correctly identify individuals with the condition in about 75% to 85% of cases. The specificity of the DGP-IgG test is reported to range from 75% to 95%, which means it can correctly identify individuals without the condition in about 75% to 95% of cases.

At this point your doctor should schedule an endoscopy to confirm celiac disease. If this test should end up negative I would still consider non-celiac gluten sensitivity.

Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.

 

 

Russ H Community Regular
Russ H
Posted
14 hours ago, phosphene said:

I've been searching through this forum and online but haven't gotten a clear answer, so I thought I would post my results specifically. My understanding is that a high gliadin IgG isn't really enough for a diagnosis, but what does it mean?

You have isolated DGP-IgG. This is common in people who do not have coeliac disease and so by itself is not usefully predictive.

https://onlinelibrary.wiley.com/doi/full/10.1111/jpc.16071

Scott Adams Grand Master
Scott Adams
Posted

The study referenced looks at 26 children, and many other larger studies have shown the overall accuracy I mentioned. The next step would likely be another biopsy, if that is what your doctor recommended. To do that you'd need to keep eating gluten daily until all testing is completed.

knitty kitty Grand Master
knitty kitty
Posted

This article refutes the article in the post left by @Russ H.

Can we ignore the utility of deamidated gliadin peptide in the diagnosis of celiac disease in children?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697416/

And another article about the value of the DGP IgG test...

Diagnostic accuracy of anti-DGP (IgG) for celiac disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071923/

 

  • 4 weeks later...
Russ H Community Regular
Russ H
Posted

These references do not refute the paper I posted.

The second reference, "Diagnostic accuracy of anti-DGP (IgG) for celiac disease", does not compare isolated anti-DGP with anti-tTG2. This is a common mistake - when both anti-DGP and anti-tTG2 are raised it indicates coeliac disease. However, isolated anti-DGP is not predictive of coeliac disease in adults.

The first reference is a letter to the journal. The authors do not state when the serum testing was performed - at diagnosis or on a gluten-free diet - and there is no control group, so cannot derive a positive predictive value. It is not uncommon to have raised anti-DGP in the general population: someone with coeliac disease without raised anti-tTG2 antibodies may indeed have raised anti-DGP antibodies but this is likely incidental and not caused by coeliac disease itself.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


frieze Community Regular
frieze
Posted
On 9/20/2023 at 1:33 AM, trents said:

Welcome to the forum, phosphene!

DGP IGG is quite high! It is not borderline. It certainly can indicate celiac disease but the test is not as specific as the tTG-IGA for celiac disease.

One thing that can throw false negatives for the tTG-IGA is low total serum IGA but that test was not ordered.  It should have been. Another thing that can drive the tTG-IGA score downward is commencing a gluten free or lower gluten diet ahead of the blood draw.

The last test listed is IGA

trents Grand Master
trents
Posted
1 hour ago, frieze said:

The last test listed is IGA

Yes, I see that now. Yours is not low.

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      126,059
    • Most Online (within 30 mins)
      7,748
    Deb W
    Newest Member
    Deb W
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.1k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Kathleen JJ
      Options - 7 year old boy - Helicobacter pylori and serology

      By Kathleen JJ · Posted

      And yes, of course it's better to know and we will adjust.  It's just, he's 7 and in our house we can control what he gets. But he plays soccer 3 times a week and in the changing room the boys share candies. I can and will tell him not to accept them any more, but "mistakes" will be made.   I'm really burdened by the potential social impact for him. He so loves to go to a restaurant as a family - I'll guess that's finished. Going to birthday parties at another kids house? I am reading about Coeliacs and apparently the fact that something as much as TOUCHED something with wheat is enough, even if he doesn't feel the symptoms - how can we control that bar from keeping him locked up?    And the worst worry of all: how do you tell a little boy to do all of this to not have symptoms that he does not have. If he'd been having horrible diarrhea or feeling really tired, we could tell him 'see, you feel so much better now, that kind of food was just not good for your body', but now, what will our argument be? For clarity: of course we will put him on the diet, I am not saying I don't believe in the necessity of that, it is just that it will be quite a stretch to 'sell' it to him 😞
    • StaciField
      My bone structure is disintegrating and I’m having to have my teeth removed

      By StaciField · Posted

      I’m 41. You have helped me achieve the goals of finding a way of getting nutrients into my body so I will see how it works for me. Thank you so much.
    • Kathleen JJ
      Options - 7 year old boy - Helicobacter pylori and serology

      By Kathleen JJ · Posted

      Thank you for your reaction. The reference values are both "<10", although I found a medical paper from Netherlands (I'm Belgian) who use the same values and there the see a positive daignosis as twice more then 200 and a positive biopsie. I didn't see how to change this in my original message, sorry...
    • cristiana
      Options - 7 year old boy - Helicobacter pylori and serology

      By cristiana · Posted

      Hi Kathleen Welcome to the forum. I am based in the UK so I am just picking this post up before our US based moderators appear.  I think they will want to know the lab values of both of the figures you have provided us with (min/max reading) as they tend to vary - could you post those for us, please? We see a lot of coeliacs who also have helicobacter pylori on this forum.  I am not sure how that would reflect in the blood results so I will leave this to be answered by my more experienced colleagues @trents or @Scott Adams. Obviously, you won't really know for sure where things stand until you have your meeting with the consultant.  I am sorry that you have to wait, but it will be worth knowing one way or another.  Apart from his recent gastric issues, it is fantastic to know that your son is otherwise a picture of health.  But it is worth bearing in mind that undiagnosed coeliac disease can cause health issues in the longer term, so far better to know now if he does turn out to have coeliac disease and adapt your son's diet accordingly, before other health issues have a chance to appear. Cristiana  
    • Kathleen JJ
      Options - 7 year old boy - Helicobacter pylori and serology

      By Kathleen JJ · Posted

      Hi all, I'm very new at this and 'this' has been quite a rollercoaster ride.   Last august my 7 year old son suddenly had these colic like pain attacks that would come a few times per day/night during 10 days. Because they were that bad and because our older daughter had her appendix taken out at 7, we ended up at ER twice to have him checked out. On both accounts blood was taken, on one account an ultrasound was made, showing swollen lymph nodes around the stomach, and the working theory was it was a violent reaction to a viral infection (even though he was not nauseous nor had diarrhea or anything like that). After 10 days it stopped as suddenly as it came on.   On October 1d my daughter started vomiting in the middle of the night, had a fever, and my son also threw up once (no fever). We kept them home from school, daughter kept on vomiting, fever stayed, son was perfectly healthy during the day, although he only ate yoghurt to be safe. The plan was to let him go to school the day after. In the night prior to his school return however, he woke up at 1, screaming with pain, begging to go to ER, which we did - the pain from august had returned.   Again bloodwork, but nothing found. It ended up only being that one pain attack, but because they were that bad, we went to the pediatrician the week after to have him checked up more thoroughly. He is a very energetic, sporty boy and he showed off his six pack with great pride to the doctor. She said he looked as an example of health, but did a more extended search because as the last blood test his liver values had been ever so slightly raised and she wanted to see how they'd do after a month.    So on November 8 we had his blood drawn again. His liver values had returned to normal, which did confirm the working theory that his pains were viral-infection triggered.   However, to everyone's (including the doctor) surprise, he also had these values: Transglutaminase IgA + >128 U/mL Gliadine IgG + 123.0 U/mL    I take it these are quite high. So last Tuesday he got his gastroscopy done, we'll have the result around the 25d we hope.  Whilst going for taking samples of the bowel, the gastro enterologist did notice some nodes in his stomach that present like a reaction to a Helicobacter pylori type infection, which would very much explain the type of pains he had.   We are still very much in shock by the Ceoliakie diagnosis (I know, it still needs to be confirmed by the biopsy, but with those numbers we kind of expect it) as he has no symptoms at all. The doctor said 'once he goes on a gluten free diet you'll see him blossom into an energetic, more happy boy' and we're like: but he is bouncing around singing and joking all day, I really can't imagine him being MORE energetic and happy - meaning, he's welcome to be that of course, but this is not a tired, withdrawn kid.   And even if the biopsy gets back negative (unlikely), what could these numbers have meant then? Could the Helicobacter pylori have an influence on this?   I have so many questions but are only eligible for a consult on December 6d so my data driven mind is going crazy having so little information or knowing so little about what everything means...   Kind regards, Kathleen  
×
×
  • Create New...