Not Celiac.....right?

[trents]

1 hour ago, Stumplet said:

Apologies for jumping on here, but I found your comment very interesting.

For some background I have coeliac symptoms, but tested negative (or more accurately below threshold for a postive test - very small amounts of antibodies were there) on tTG, and DCP. I am not igA deficient. I have the HLA-DQ8 gene.

I have been looking into getting the anti-endomysial blood test to see if that was positive however your comment made me pause.

I have persistantly low ferritin (under 10), dipping into anemia sometimes. I have persistently low vitamin D. I periodically treat both of these with supplements to get them into normal range. My ferritin is currently low again. It was also noted on one of my blood tests my IgM was below the normal range and my GP didn't know why.

Is it possible that I might just not be making enough coeliac antibodies due to deficincies? Or would I need to have very severe deficeiences for this to be possible? Maybe this isn't likely however as i've had other antibody tests which were positive (hashimotos, anti-mitochondrial) or are the production of some antibody types more severly impacted by deficiencies than others?

Thanks!

Have you had total IGA level tested? If total IGA is low, it will often cause false negatives in other celiac antibody tests such as the tTG-IGA.

[Stumplet]

11 minutes ago, trents said:

Have you had total IGA level tested? If total IGA is low, it will often cause false negatives in other celiac antibody tests such as the tTG-IGA.

Thanks for your reply

Yes my IgA is normal, only my IgM was slightly low (but nowhere near the level of a IgM deficiency which are apparently incredibly rare)

[trents]

3 minutes ago, Stumplet said:

Thanks for your reply

Yes my IgA is normal, only my IgM was slightly low (but nowhere near the level of a IgM deficiency which are apparently incredibly rare)

IgM?

[Stumplet]

15 minutes ago, trents said:

IgM?

Immunoglobulin m, I don't think this being a bit low is directly relevant to my coeliac antibody tests. However, I didn't know what another user posted about iron and vit d deficieny impacting antibody production. So i just mentioned it on the off chance it was relevant