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Still produce antibodies after 30 years?


eekunique

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eekunique Apprentice

I'm 41 and I've had the symptoms of celiac since I was about 8! "Diagnosed" with IBS at 15. I have a blood test in a couple of weeks. 

If I did have celiac from a young age, would I still be producing antibodies after 30 years? 

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plumbago Experienced
2 minutes ago, eekunique said:

I'm 41 and I've had the symptoms of celiac since I was about 8! "Diagnosed" with IBS at 15. I have a blood test in a couple of weeks. 

If I did have celiac from a young age, would I still be producing antibodies after 30 years? 

You would if you have celiac and are still eating gluten.

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Wheatwacked Veteran

     One of the reasons it is so hard to diagnose Celiac Disease in adults is the widely held belief that Celiac Disease is just a "childhood disease" and we grow out of it.  I think that once we are old enough to choose what we eat, without parental or peer pressure, we unconciously learn to avoid the foods that bother us the most, and take antacids when we can't.

"No TV if you don't clean your plate"

     If you don't eat gluten, barring cross-contamination, you will not produce antibodies.  If you want to ensure an accurate test result, be sure to eat 10 grams of glutenor more a day; the equivalent of four slices of bread.

Welcome to the forum.  Good luck (?) with your testing.

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knitty kitty Grand Master

Here's the updated gluten challenge guidelines...

According to recent research, updates to the gluten challenge are being implemented.

Recommended intake of gluten should be increased to 10 grams of gluten per day for at least two weeks. Or longer.

While three grams of gluten will begin the immune response, ten grams of gluten is needed to get antibody levels up to where they can be measured in antibody tests and changes can be seen in the small intestine.  

Keep in mind that there are different amounts of gluten in different kinds of bread and gluten containing foods.  Pizza crust and breads that are thick and chewy contain more gluten than things like cake and cookies.  

References:

https://www.beyondceliac.org/celiac-disease/the-gluten-challenge/

And...

Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878429/?report=reader

 "In our study, limited changes in Vh:celiac disease (villi height vs crypt depth - aka damage to the small intestine)  following 14-day challenge with 3 g of gluten were observed, in accordance with Sarna et al.  While the 3 g dose was sufficient to initiate an immune response, as detected by several biomarkers such as IL-2, the 10 g dose was required for enteropathy within the study time frame. Based on our data, we would suggest that gluten challenge should be conducted over longer durations and/or using doses of gluten of ≥ 3 g/day to ensure sufficient histological change can be induced."
Keep us posted on your progress!

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