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DH and Iodine

Wheatwacked

By Wheatwacked
in Dermatitis Herpetiformis

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Go to solution Solved by knitty kitty,

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Wheatwacked Veteran
Wheatwacked
Posted

Could the exacebation effect on DH associated with iodine be the histamine content of the food, and not the iodine itself?

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knitty kitty Grand Master
knitty kitty
Posted
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(edited)

Nope.  Iodine makes the DH antibodies tTg 3 more active.

Blood tests for Celiac Disease tests for tTg 2. 

TTg 3 is found in DH eruptions.  

TTg 6 is found in Celiac people with ataxia because it attacks the brain.   TTg 6 is also found in Alzheimer's and Parkinson's dementia.  

Dermatitis herpetiformis resistant to dapsone due to dietary iodide ingestion

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698721/

"The IgA antibodies to transglutaminase 3 complexes in DH skin are known to be enzymatically active. This enzymatic activity is dramatically increased in the presence of iodide."

Edited by knitty kitty
Typo
Wheatwacked Veteran
Wheatwacked
Posted
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Thanks

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