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Test Results

Jordan Carlson
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Jordan Carlson Explorer
Jordan Carlson
Posted

Hey everyone! Just wondering if anyone else is comfortable comparing blood test results to mine.  When I tested positive on the blood test (Tissue Transglutaminase Ab IgA) my result came back at 40.2 U/mL. I have read that some people have a much lower number than me and will get the endoscopy biopsy done and still have the disease present and get the celiac diagnosis. More or less just want to know if my number is pretty high or if its a pretty common result. Thanks!

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RMJ Mentor
RMJ
Posted

The units used to report celiac antibody results can be quite different from lab to lab because they are not absolute weight/volume measurements.  Even within a lab they can change.  The lab where I’ve had celiac tests done has used tests with normal ranges of 0-19, then 0-3, and now 0-4.99.

What is the normal range for normal for your test?

Also, antibody levels don’t always correlate with intestinal damage levels.

Jordan Carlson Explorer
Jordan Carlson
Posted
  • Author

The Tissue Transglutaminase Ab IgA test normal range is 12 U/mL or less. And my result was 40.2 U/mL.

RMJ Mentor
RMJ
Posted

My initial TTG IgA was 110 with a normal range of 19 or less. My DGP IgA was 143 with the same range. I had an endoscopy after being on a gluten free diet for 3-1/2 years (delay unrelated to celiac) when my TTG IgA was down to 3 (normal) and DGP IgA down to 29 (high) and I still had Marsh 3A damage.

Jordan Carlson Explorer
Jordan Carlson
Posted
  • Author

Very interesting. Thank you for sharing! I have my endoscopy/colonoscopy in about 2 and a half weeks to confirm celiac and also test for suspected inflammatory bowel disease so I have no idea the extent of the damage to my insides or anything like that. Will be interesting to see what comes of it. Thank you again!

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    • trents
      Awaiting diagnosis

      By trents · Posted

      I would ask for a total IGA test (aka, Immunoglobulin A (IgA) and other names as well) to check for IGA deficiency. That test should always be ordered along with the TTG IGA. If someone is IGA deficient, their individual celiac IGA test scores will be artificially low which can result in false negatives. Make sure you are eating generous amounts of gluten leading up to any testing or diagnostic procedure for celiac disease to ensure validity of the results. 10g of gluten daily for a period of at least 2 weeks is what current guidelines are recommending. That's the amount of gluten found in about 4-6 slices of wheat bread.
    • jlp1999
      Awaiting diagnosis

      By jlp1999 · Posted

      There was not a total IGA test done, those were the only two ordered. I would say I was consuming a normal amount of gluten, I am not a huge bread or baked goods eater
    • trents
      Awaiting diagnosis

      By trents · Posted

      Were you consuming generous amounts of gluten in the weeks leading up to the blood draw for the antibody testing? And was there a Total IGA test done to test for IGA deficiency?
    • jlp1999
      Awaiting diagnosis

      By jlp1999 · Posted

      Thank you for the reply. It was the TTG IGA that was within normal limits
    • trents
      Awaiting diagnosis

      By trents · Posted

      Welcome to the forum, @jlp1999! Which IGA test do you refer to as being normal? TTG-IGA? Total IGA? DGP-IGA? Yes, any positive on an IGA or an IGG test can be due to something other than celiac disease and this is especially true of weak positives. Villous atrophy can also be cause by other things besides celiac disease such as some medications, parasitic infections and even some foods (especially dairy from an intolerance to the dairy protein casein). But the likelihood of that being the case is much less than it being caused by celiac disease.
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