Histology results

[awright24]

 

Hi, 

Can anyone break this down/explain this to me please? 

I have confirmation that i have celiac disease but dont have an appointment to discuss with the gastroenterologist until November so just wondered if anyone could break this down for me. 

 

Pieces Of duodenal mucosa and muscularis mucosae showing partial villous atrophy. The number Of intraepithelial Iymphocytes is increased. There is hyperplasia Of the crypts with loss Of Goblet cells. Mild increase in chronic inflarmation is seen in the lamina propria. There is no evidence Of dysplasia or malignancy.

Concl us i on

Duodenal biopsies: partial villous atrophy compatible with coeliac disease

 

[Scott Adams]

Your biopsy results indicate several key findings that are consistent with celiac disease:

• Partial Villous Atrophy: This means that the villi (small finger-like projections in the small intestine that help absorb nutrients) are partially flattened. This is a common feature of celiac disease.
• Increased Intraepithelial Lymphocytes: This indicates a higher number of immune cells within the lining of the intestine, which is another hallmark of celiac disease.
• Crypt Hyperplasia: This refers to the enlargement of the crypts (glandular structures in the lining of the intestine), which is often seen in celiac disease.
• Loss of Goblet Cells: Goblet cells produce mucus, and their loss can be associated with inflammation and damage to the intestinal lining.
• Mild Increase in Chronic Inflammation: This indicates ongoing inflammation in the lining of the intestine.
• No Evidence of Dysplasia or Malignancy: This is a positive finding, indicating that there are no precancerous or cancerous changes in the tissue.

The conclusion of “partial villous atrophy compatible with celiac disease” means that these findings are consistent with a diagnosis of celiac disease.