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Unusual high levels


Nielskii

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Nielskii Newbie

Hi all! I hope you guys are doing well. A few weeks ago I started feeling a bit odd in the stomach with some minor cramps here and there. I decided to get my blood tested and I got a score of 573 on the tTG-IgA test! I get that some people have asymptomatic celiac disease but this seems very odd. Is there something I should about this? 


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Scott Adams Grand Master

Do you know the reference range for your test? It can be different depending on the lab that processed the test.

In the Europe the new protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease.

According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy:

There are other things that may cause elevated tTg-IgA levels, but in general a reaction to gluten is the culprit:

 

 

trents Grand Master

Check with your doctor to find out if he/she wants to refer you to a GI specialist for an endoscopy/biopsy to confirm the results of the blood antibody testing or whether or not the tTG-IGA levels are high enough to grant a celiac disease diagnosis without further tests being done. If further testing is expected, you need to refrain from starting a gluten free diet or you risk sabotaging the tests.

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    • trents
      Usually, the blood testing is done first and the endoscopy/biopsy follows for confirmation if there are positive antibody test scores. Historically, the endoscopy with biopsy has been considered to be the gold standard for diagnosing celiac disease. If the tTG-IGA scores are very high (5x-10x normal), some doctors will forego the endoscpoy/biopsy and grant a celiac disease diagnosis without it. So, if you are starting with the endoscopy/biopsy that may be all you need to arrive at a diagnosis. Another possibility would be for the GI doc to do a blood draw for antibody testing on the same day you come in for the endoscopy/biopsy.
    • AuntieAutoimmune
      Thanks,Scott. Yes, I had already seen those 
    • Scott Adams
      Unless your blood antibody levels are 10x the celiac disease positive level they usually do an endoscopy to confirm the diagnosis.  Here is more info about how to do a gluten challenge for a celiac disease blood panel, or for an endoscopy: and this recent study recommends 4-6 slices of wheat bread per day:    
    • growlinhard1
      I haven't had any of this blood work and my GI doctor immediately scheduled the endoscopy with biopsy based on the large area of inflammation found during my colonoscopy and me relating all the other symptoms I'm experiencing. If the blood testing is positive do you still have to have the endoscopy with a positive biopsy to be definitively diagnosed with celiac? Seems like a waste of money and risk to do it backwards 😕 
    • Scott Adams
      Many super sensitive celiacs do have issues with this, especially if they work in a bakery or area where flour may be in the air. Some even seem to have issues being in areas where bread is being baked. Here are some threads here on this:    
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