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Best Lab To Get Full Panel Bloodwork For Accurate Celiac Results


cillivilli
Go to solution Solved by trents,

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cillivilli Newbie

I read that different labs use different testing techniques which can effect TTg-Iga results. Which Lab should I have my TTg-Iga blood test and which one does a full panel test?


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  • Solution
trents Grand Master

The antibody blood tests used to diagnose celiac disease are standardized in the sense of what is being measured. How the tests are conducted and the scales used (as well as the units used) to express the results can vary from lab to lab. This does not affect the accuracy of the testing. So, there shouldn't be an issue with choosing one lab over another to ensure testing accuracy. What you don't want to do is to compare test results from two different time periods done by two different labs. If you are wanting to compare blood antibody test results over time, then the tests would need to have been done by the same lab in order for the comparison to be meaningful. And by the way, the TTG-IGA is not the only celiac antibody test that can be run nor is the only one that should be run. At least a "total IGA" test should be ordered whenever the tTG-IGA is ordered to make sure the tTG-IGA result is not invalidated by IGA deficiency. Here is an article outlining the various tests that can be ordered to diagnose celiac disease: 

 

 

 

Scott Adams Grand Master

I agree with @trents, but for genetic tests it does seem like there are some variations between different labs and the celiac gene markers that are included, but for your celiac disease blood test just make sure that a full celiac disease panel is done that includes total IgA.

cillivilli Newbie

Thank you @trents and @Scott Adams your input was very helpful! 

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    • trents
      Possibly. Your total IGA (Immunoglobulin A, Qn, Serum) is actually high so you are not IGA deficient. In the absence of IGA deficiency, the most reliable celiac antibody test would be the t-Transglutaminase (tTG) IgA for which your score is within normal range. There are other things besides celiac disease that might cause an elevated DGP-IGA (Deamidated Gliadin Abs, lgA) for which you do have a positive score. It might also be of concern that your total IGA is elevated as that can indicate some other health problems, some of which are serious.  Had you been practicing a gluten free or a reduced gluten free diet prior to the blood draw? Talk to your physician about these things. I would also seek an endoscopy/biopsy of the small bowel to check for damage to the villous lining, which is the gold standard diagnostic test for celiac disease.
    • MicG
      Test results as follows: Deamidated Gliadin Abs, lgA 40 H (normal range 0-19) Deamidated Gliadin Abs, IgG 4 (0-19) t-Transglutaminase (tTG) IgA <2 (0-3) t-Transglutaminase (tTG) IgG <2 (0-5) Endomysial Antibody IgA Negative (Negative) Immunoglobulin A, Qn, Serum 535 H (87-352) Do I have celiac?
    • catnapt
      how long does it take for the genetic blood test for celiac to come back? I saw the GI today, she was great. She says I def have an issue with gluten and that my symptoms align more with celiac disease than NCGS, so she's doing the genetic testing, Ordered a test for SIBO but said that's just to cover all bases, she doesn't think I have that. If the blood work comes back negative for the genes, then I will cancel the endoscopy. If positive, I will try the 2 week gluten challenge and get the endoscopy done. If I can't manage the gluten challenge (I had HORRIBLE symptoms last time and quit after 12 days) then we'll just assume it's celiac disease and go from there. She says she does a full nutrient panel on all her pts every year, that was nice to hear.I'm on so many supplements it would be nice to only have to get the ones I truly need! so yeh, really anxious about the test results for the genes!! I have an identical twin sister so I'd need to tell her if it's positive, she'd prob want to get tested too. *interesting note: when I said if the blood work comes back that I don't have the genes, then I'm in the clear - she said, well,,,,,,not necessarily. But she didn't want to go into as we had a lot to go over. I did make a  mental note of that comment and will ask her when I see her next time.   she was very thorough! I was impressed! she even checked- up on some lab work I had done that my Endo ordered. I like her, I am looking forward to seeing her again. I think I'll get some good advice and info from her she also complimented me on my diet.   said it was a very gut friendly and healthy diet 
    • Scott Adams
      I'm not sure why "colonoscopy" keeps coming up for you, again it would be an endoscopy to diagnose celiac disease, but it seems that Kaiser should still have your records. If you were diagnosed by them in the 1990's using a blood test and endoscopy, then you definitely have celiac disease, and hopefully you've been gluten-free since that time. You should be able to contact Kaiser for those records.
    • Russ H
      This sounds like a GP who is ignorant regarding coeliac disease. The risk with consuming gluten for several days is that it triggers the coeliac immune response, leading to raised auto-antibodies and active disease for several months. People may not even be aware of symptoms during this process, but it is causing damage to the body. As trents has said, the gut lining normally recovers on a strict gluten-free diet, and this happens much faster in children than in adults.
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