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What do my test results mean?

jmiller93
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jmiller93 Newbie
jmiller93
Posted

Hello!

I just was notified of my test results of my celiac reflex panel. The ttg-iga was <2, but the iga was high-366. 

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trents Grand Master
trents
Posted

Welcome to the forum, @jmiller93!

What was the range used by that lab to establish positive vs. negative? Different labs use different ranges. There is no industry standard. But the number is low enough to suggest a negative test result for the tTG-IGA. That one is actually an antibody test used to detect celiac disease. The other one, the "IGA" at 366 is what we commonly call "total IGA". It is not a test for celiac disease per se but is used to check for IGA deficiency. If there is IGA deficiency, the individual IGA antibody tests can give falsely low, results, and even result in false negatives.

Obviously, you are not IGA deficient. A high total IGA is of no particular consequence with regard to indicating other health issues not related to celiac disease as far as I know but check with your physician to be sure.

It needs to be pointed out that if you had already been withholding gluten from your diet prior to the blood draw done for celiac antibody testing, that would invalidate the testing.

It also needs to be said that testing negative for celiac disease does not rule out the possibility of having NCGS (Non Celiac Gluten Sensitivity). What caused you to see celiac disease testing? What are your symptoms?

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jmiller93 Newbie
jmiller93
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Posted

My physician messaged and said I had a negative panel. I was diagnosed with IBS as a teenager and have had GI issues ever since. I have chronic diarrhea, abdominal pain, chronic fatigue, nausea.

I am adopted and didn’t know my medical history, so I took a dna test a few years ago. I had tested positive for one of the markers, so said I was at increased risk of developing. The panel was to rule out, so I guess it’s been ruled out. 

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trents Grand Master
trents
Posted

You still may have NCGS. NCGS shares many of the same symptoms of celiac disease but does not damage the lining of the small bowel as does celiac disease. There is no test for it. A diagnosis for NCGS depends on first ruling out celiac disease. It is 10x more common than celiac disease. Some experts feel it can be a precursor to the development of celiac disease. Eliminating gluten from your life is the antidote for both.

You would do well to consider trialing the gluten free diet to see if your symptoms improve.

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jmiller93 Newbie
jmiller93
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Posted

Thank you! I might give it a try.

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      What do my test results mean?

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      Thank you! I might give it a try.
    • trents
      What do my test results mean?

      By trents · Posted

      You still may have NCGS. NCGS shares many of the same symptoms of celiac disease but does not damage the lining of the small bowel as does celiac disease. There is no test for it. A diagnosis for NCGS depends on first ruling out celiac disease. It is 10x more common than celiac disease. Some experts feel it can be a precursor to the development of celiac disease. Eliminating gluten from your life is the antidote for both. You would do well to consider trialing the gluten free diet to see if your symptoms improve.
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