Help with results please. As I have a appt after the New Year.

[Jtestani]

My question is .. my test results

Ttg (IgA 1.7 u/ml & IgG 3:3 u/ml)  both negative &

DGP IGG 7.1025 negative

but DGP IGA postive at 36.2007 U/ML. 

Am I showing a negative test result? 
any insight helps as I have to wait till new year for next Doctor’s appt. 
Thanks 

[trents]

The positive DGP-IGA indicates the possibility of celiac disease. It is typical for someone who does have celiac disease to have some antibody tests be negative and others positive. This is not unique to celiac disease diagnosis. It is why doctors typically run many tests when seeking diagnosis of a suspected disease. 

The DGP-IgA test is considered to have high sensitivity and specificity. In general, the DGP-IgA test has been reported to have a sensitivity ranging from 75% to 95% and a specificity ranging from 90% to 100%. Overall, the DGP tests, including DGP-IgA and DGP-IgG, exhibit a sensitivity of approximately 85-95% and a specificity of about 95-98%.

The above paragraph is taken from this article which gives an overview of the various tests that can be run for celiac disease and their reliability:

What symptoms are you experiencing?

[Scott Adams]

One positive blood test result means you likely have celiac disease, but to confirm it they may want to do an endoscopy to verify it with biopsies. Unless you have severe symptoms now, you likely should continue eating gluten daily until all testing is completed, and should eat tons of gluten daily in the 2 weeks before an endoscopy.

[JettaGirl]

My blood tests didn’t show I had Celiac’s but the endoscopy did. The test is easy and you feel nothing after, it’s basically like taking a nap. The worst part is getting the IV, which is pretty easy and basic, hopefully this helps!

[Celiac comments]

I had 2 blood tests at the same time. One negative, one positive.  No insurance coverage for endoscopy but felt MUCH MUCH better after three days gluten-free and many hair, skin, and rash issues cleared or improved in a week. It seems there are lots of false negatives in Celiac blood tests. 

[trents]

  On 12/4/2024 at 5:25 PM, Celiac comments said:

I had 2 blood tests at the same time. One negative, one positive.  No insurance coverage for endoscopy but felt MUCH MUCH better after three days gluten-free and many hair, skin, and rash issues cleared or improved in a week. It seems there are lots of false negatives in Celiac blood tests. 

Expand Quote  

You are confusing two different things. You are confusing seronegative celiac disease, in which all celiac antibody tests will be negative despite a positive biopsy, with mixed positive and negative antibody tests. It is normal for someone with celiac disease to not have all antibody tests throw positives. That's why they have developed different antibody tests. What one misses, another may catch. It is the same way when diagnosing many other medical conditions. Usually, not all diagnostic tests for that condition will be positive. You have to look at the total body of evidence.

[JettaGirl]

Thank you! It was never explained to me why it didn’t show up in the labs. This makes so much more sense to me now. The endoscopy test was very easy though. I was worried about my first one and have had 2 since. I don’t think I was able to eat after midnight because of anesthesia, the procedure itself took 20 minutes. I did need a driver to get me home after just where I was put under anesthesia for the procedure. 

[trents]

JettaGirl, there are a number of serum antibody tests that can be ordered when diagnosing celiac disease. Unfortunately, most physicians will only order one or two. So, a negative on those one or two may or may not add up to seronegative celiac disease since had a "full celiac antibody panel" been ordered you may have thrown some positives. False negatives in the IGA antibody tests can also be caused by low total IGA count. So, a "total IGA" test should always be ordered along with the single most popular test, the tTG-IGA. Unfortunately, many physicians only order the tTG-IGA. And then there are other tests that are IGG based. A full celiac panel will include both the IGA tests and the IGG tests. Here is a primer: 

And here's another article on seronegative celiac disease:

https://pmc.ncbi.nlm.nih.gov/articles/PMC4586545/